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公开(公告)号：US20230340013A1
公开(公告)日：2023-10-26
申请号：US18198205
申请日：2023-05-16
发明人： Jason CHIN , Kathrin LANG
CPC分类号： C07K1/006 , G01N33/582 , C07K2/00 , C07C271/22 , C07K1/13 , C12N9/93 , C12Y601/01026 , C07C2602/24
摘要： The invention relates to a polypeptide comprising an amino acid having a bicyclo[6.1.0]non-4-yn-9-ylmethanol (BCN) group, particularly when said BCN group is present as: a residue of a lysine amino acid. The invention also relates to a method of producing a polypeptide comprising a BCN group, said method comprising genetically incorporating an amino acid comprising a BCN group into a polypeptide. The invention also relates to an amino acid comprising bicyclo[6.1.0]non-4-yn-9-ylmethanol (BCN), particularly and amino acid which is bicyclo[6.1.0]non-4-yn-9-ylmethanol (BCN) lysine. In addition the invention relates to a PylRS tRNA synthetase comprising the mutations Y271M, L274G and C313A.
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公开(公告)号：US20220010296A1
公开(公告)日：2022-01-13
申请号：US17288798
申请日：2019-10-24
发明人： Jason CHIN , Nicolas HUGUENIN-DEZOT , Mohan MAHESH , Shan TANG , Duy P. NGUYEN
IPC分类号： C12N9/00 , C07D317/62 , C12N9/50
摘要： The invention relates to genetic incorporation of 2,3-diamino propionic acid (DAP) into polypeptides, to unnatural amino acids comprising DAP, to a tRNA synthetase for charging tRNA with unnatural amino acids comprising DAP, and to methods of using the resulting polypeptides, for example in capturing substrates and/or intermediates in enzymatic reactions. The invention also relates to compounds of formula (I) or (II): or salts, solvates, tautomers, isomers or mixtures thereof.
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公开(公告)号：US20200271658A1
公开(公告)日：2020-08-27
申请号：US16872826
申请日：2020-05-12
发明人： Jason CHIN , Kathrin LANG
摘要： The invention relates to a polypeptide comprising an amino acid having a bicyclo[6.1.0]non-4-yn-9-ylmethanol (BCN) group, particularly when said BCN group is present as: a residue of a lysine amino acid. The invention also relates to a method of producing a polypeptide comprising a BCN group, said method comprising genetically incorporating an amino acid comprising a BCN group into a polypeptide. The invention also relates to an amino acid comprising bicyclo[6.1.0]non-4-yn-9-ylmethanol (BCN), particularly and amino acid which is bicyclo[6.1.0]non-4-yn-9-ylmethanol (BCN) lysine. In addition the invention relates to a Py1RS tRNA synthetase comprising the mutations Y271M, L274G and C313A.
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