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公开(公告)号：US20240307445A1
公开(公告)日：2024-09-19
申请号：US18590493
申请日：2024-02-28
IPC分类号： A61K35/17 , A61K38/00 , A61K38/45 , C07K2/00 , C07K16/30 , C07K16/40 , C12N5/0783 , C12N9/16 , C12N15/113
CPC分类号： A61K35/17 , C07K2/00 , C07K16/30 , C07K16/40 , C12N5/0638 , C12N9/16 , C12N15/1137 , A61K38/00 , A61K38/45 , C12N2310/11 , C12N2310/14 , C12N2310/531 , C12Y207/01107
摘要： The present invention provides compositions and methods for inhibiting one or more diacylglycerol kinase (DOK) isoform in a cell in order to enhance the cytolytic activity of the cell. In one embodiment, the cells may be used in adoptive T cell transfer. For example, in some embodiments, the cell is modified to express a chimeric antigen receptor (CAR). Inhibition of DOK in T cells used in adoptive T cell transfer increases cytolytic activity of the T cells and thus may be used in the treatment of a variety of conditions, including cancer, infection, and immune disorders.
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公开(公告)号：US11931380B2
公开(公告)日：2024-03-19
申请号：US17230791
申请日：2021-04-14
IPC分类号： A61K35/17 , C07K2/00 , C07K16/30 , C07K16/40 , C12N5/0783 , C12N9/16 , C12N15/113 , A61K38/00 , A61K38/45
CPC分类号： A61K35/17 , C07K2/00 , C07K16/30 , C07K16/40 , C12N5/0638 , C12N9/16 , C12N15/1137 , A61K38/00 , A61K38/45 , C12N2310/11 , C12N2310/14 , C12N2310/531 , C12Y207/01107 , C12N2310/14 , C12N2310/531
摘要： The present invention provides compositions and methods for inhibiting one or more diacylglycerol kinase (DGK) isoform in a cell in order to enhance the cytolytic activity of the cell. In one embodiment, the cells may be used in adoptive T cell transfer. For example, in some embodiments, the cell is modified to express a chimeric antigen receptor (CAR). Inhibition of DGK in T cells used in adoptive T cell transfer increases cytolytic activity of the T cells and thus may be used in the treatment of a variety of conditions, including cancer, infection, and immune disorders.
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公开(公告)号：US09937205B2
公开(公告)日：2018-04-10
申请号：US14425452
申请日：2013-09-04
IPC分类号： A61K35/14 , A61K35/17 , C12N15/113 , C12N5/0783 , C07K16/30 , C07K2/00 , C07K16/40 , C12N9/16 , A61K38/45 , A61K38/00
CPC分类号： A61K35/17 , A61K38/00 , A61K38/45 , C07K2/00 , C07K16/30 , C07K16/40 , C12N5/0638 , C12N9/16 , C12N15/1137 , C12N2310/11 , C12N2310/14 , C12N2310/531 , C12Y207/01107
摘要： The present invention provides compositions and methods for inhibiting one or more diacylglycerol kinase (DGK) isoform in a cell in order to enhance the cytolytic activity of the cell. In one embodiment, the cells may be used in adoptive T cell transfer. For example, in some embodiments, the cell is modified to express a chimeric antigen receptor (CAR). Inhibition of DGK in T cells used in adoptive T cell transfer increases cytolytic activity of the T cells and thus may be used in the treatment of a variety of conditions, including cancer, infection, and immune disorders.
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4.发明申请公开(公告)号：US20150224142A1
公开(公告)日：2015-08-13
申请号：US14425452
申请日：2013-09-04
IPC分类号： A61K35/17 , C12N9/16 , C07K2/00 , C12N15/113 , C07K16/40
CPC分类号： A61K35/17 , A61K38/00 , A61K38/45 , C07K2/00 , C07K16/30 , C07K16/40 , C12N5/0638 , C12N9/16 , C12N15/1137 , C12N2310/11 , C12N2310/14 , C12N2310/531 , C12Y207/01107
摘要： The present invention provides compositions and methods for inhibiting one or more diacylglycerol kinase (DGK) isoform in a cell in order to enhance the cytolytic activity of the cell. In one embodiment, the cells may be used in adoptive T cell transfer. For example, in some embodiments, the cell is modified to express a chimeric antigen receptor (CAR). Inhibition of DGK in T cells used in adoptive T cell transfer increases cytolytic activity of the T cells and thus may be used in the treatment of a variety of conditions, including cancer, infection, and immune disorders.
摘要翻译： 本发明提供用于抑制细胞中一种或多种二酰基甘油激酶（DGK）同种型的组合物和方法，以增强细胞的溶细胞活性。 在一个实施方案中，细胞可以用于过继性T细胞转移。 例如，在一些实施方案中，修饰细胞以表达嵌合抗原受体（CAR）。 在过继性T细胞转移中使用的T细胞中DGK的抑制增加T细胞的溶细胞活性，因此可用于治疗各种病症，包括癌症，感染和免疫疾病。
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