公开(公告)号：US12109259B2

公开(公告)日：2024-10-08

申请号：US16326833

申请日：2017-09-01

申请人： GLAXOSMITHKLINE BIOLOGICALS, S.A.

发明人： Mariagrazia Pizza ,  Steven B. Black

IPC分类号： A61K39/095 ,  A61K39/116 ,  A61K39/39 ,  A61K47/64 ,  C07K14/22 ,  C07K16/12 ,  A61K39/00

CPC分类号： A61K39/095 ,  A61K39/116 ,  A61K39/39 ,  A61K47/646 ,  C07K14/22 ,  C07K16/1217 ,  A61K2039/54 ,  A61K2039/55 ,  A61K2039/55505 ,  A61K2039/58 ,  C07K2317/33

摘要： A method for immunizing a subject in need thereof against Neisseria gonorrhoeae by administering an immunogenic composition comprising meningococcal outer membrane vesicles (OMVs).

公开(公告)号：US20230203091A1

公开(公告)日：2023-06-29

申请号：US18176631

申请日：2023-03-01

申请人： Pfizer Inc.

发明人： Mingming Han ,  Rajesh Kumar Kainthan ,  Jin-Hwan Kim ,  Avvari Krishna Prasad

IPC分类号： C07K1/107 ,  C07K14/34 ,  C07K14/22 ,  C07K14/315 ,  A61K39/095 ,  A61K39/09 ,  A61K47/64 ,  C07H3/06

CPC分类号： C07K1/1077 ,  C07K14/34 ,  C07K14/22 ,  C07K14/315 ,  A61K39/095 ,  A61K39/092 ,  A61K47/646 ,  A61K47/6415 ,  A61K39/09 ,  C07H3/06 ,  A61K2039/6037

摘要： The present disclosure relates generally to methods of preparing glycoconjugates containing a saccharide conjugated to a carrier protein by use of stable nitroxyl radical related agent/oxidant as an oxidizing agent, to immunogenic compositions comprising such glycoconjugates, and to methods for the use of such glycoconjugates and immunogenic compositions.

公开(公告)号：US20230019488A1

公开(公告)日：2023-01-19

申请号：US17929415

申请日：2022-09-02

申请人： THE U.S.A, as represented by the Secretary, Department of Health and Human Services

发明人： Margaret Bash ,  Kathryn Matthias

IPC分类号： A61K39/095 ,  C12N1/20 ,  C07K14/22

摘要： Immunogenic compositions are disclosed that include Neisseria meningitidis microvesicles, such as outer membrane vesicles (OMV) and/or blebs, from PorA−PorB− Neisseria, such as PorA−PorB−ampM− Neisseria meningitidis. These immunogenic compositions are of use to induce an immune response to Neisseria, including Neisseria meningitidis and Neisseria gonorrhea.

公开(公告)号：US20220395567A1

公开(公告)日：2022-12-15

申请号：US17762159

申请日：2020-09-22

申请人： University of Massachusetts

发明人： Peter A. Rice ,  Michael W. Pennington

IPC分类号： A61K39/095 ,  C07K14/22 ,  C07K7/64 ,  A61P31/04

摘要： In some aspects, the disclosure relates to compositions of peptide mimics useful in the treatment of Neisseria gonorrhoeae (N. gonorrhoeae). In some embodiments, the peptide mimics are multi-antigenic molecules of a conserved gonococcal lipoohgosaccharaide (LOS) epitope. In some aspects, the disclosure relates to methods of making peptide mimics for the treatment of N. gonorrhoeae. In some aspects, the disclosure relates to methods of using peptide mimics for the treatment of N. gonorrhoeae.

公开(公告)号：US20220137051A1

公开(公告)日：2022-05-05

申请号：US17531314

申请日：2021-11-19

申请人： GLAXOSMITHKLINE BIOLOGICALS SA

发明人： Marzia Monica GIULIANI ,  Elena MORI

IPC分类号： G01N33/577 ,  C07K16/12 ,  G01N33/569 ,  A61K39/095 ,  C07K14/22

摘要： The invention uses ELISA or similar assays for analysing a meningococcal vaccine. The assay uses antibodies which bind to meningococcal proteins within the vaccine, and in particular monoclonal antibodies which are bactericidal for meningococcus and/or which recognise conformational epitopes within the meningococcal proteins. By performing the assay on a series of dilutions of a test vaccine, and by comparing the results with those obtained using a reference vaccine of known potency, it is possible to determine the relative potency of the test vaccine. This value can be used as a parameter for determining whether a manufactured batch of a vaccine is suitable for release to the public, or whether it has experienced a production failure and so should not be used.

公开(公告)号：US20210277069A1

公开(公告)日：2021-09-09

申请号：US17265610

申请日：2019-08-09

申请人： GLAXOSMITHKLINE BIOLOGICALS SA

发明人： Maria SCARSELLI ,  Daniele VEGGI

IPC分类号： C07K14/22 ,  A61K39/095 ,  A61P31/04

摘要： The present invention provides mutated fHbp polypeptides and fusion proteins comprising said mutated fHbp polypeptides that are useful as components of immunogenic compositions for immunizing against Neisseria meningitidis infection.

公开(公告)号：US20210253647A1

公开(公告)日：2021-08-19

申请号：US17245681

申请日：2021-04-30

申请人： GLAXOSMITHKLINE BIOLOGICALS SA

发明人： Matthew BOTTOMLEY ,  Enrico MALITO ,  Manuele MARTINELLI ,  Maria Scarselli

IPC分类号： C07K14/22 ,  A61K39/095

摘要： Modified meningococcal fHbp polypeptides with increased stability.

公开(公告)号：US10995122B2

公开(公告)日：2021-05-04

申请号：US16600282

申请日：2019-10-11

申请人： Children's Hospital & Research Center at Oakland

发明人： Peter T. Beernink

IPC分类号： A61K39/095 ,  C07K14/22 ,  A61K39/00

摘要： Variant factor H binding proteins that can elicit antibodies that are bactericidal for at least one strain of Neisseria meningitidis, compositions comprising such proteins, and methods of use of such proteins, are provided.

公开(公告)号：US20210101943A1

公开(公告)日：2021-04-08

申请号：US17126712

申请日：2020-12-18

申请人： Pfizer Inc.

发明人： Annaliesa Sybil Anderson ,  Rasappa Gounder Arumugham ,  John Erwin Farley ,  Leah Diane Fletcher ,  Shannon Lea Harris ,  Kathrin Ute Jansen ,  Thomas Richard Jones ,  Lakshmi Khandke ,  Bounthon Loun ,  John Lance Perez ,  Gary Warren Zlotnick

IPC分类号： C07K14/22 ,  A61K39/13 ,  A61K39/295 ,  A61K39/00 ,  A61K39/095 ,  A61K39/12 ,  A61K39/39 ,  C12N7/00

摘要： In one aspect, the invention relates to a composition including a first polypeptide having the sequence set forth in SEQ ID NO: 1 and a second polypeptide having the sequence set forth in SEQ ID NO: 2. In one embodiment, the composition includes about 120 μg/ml of a first polypeptide including the amino acid sequence set forth in SEQ ID NO: 1, 120 μg/ml of a second polypeptide including the amino acid sequence set forth in SEQ ID NO: 2, about 2.8 molar ratio polysorbate-80 to the first polypeptide, about 2.8 molar ratio polysorbate-80 to the second polypeptide, about 0.5 mg/ml aluminum, about 10 mM histidine, and about 150 mM sodium chloride. In one embodiment, a dose of the composition is about 0.5 ml in total volume. In one embodiment, two-doses of the composition induce a bactericidal titer against diverse heterologous subfamily A and subfamily B strains in a human.

公开(公告)号：US10967045B2

公开(公告)日：2021-04-06

申请号：US12758315

申请日：2010-04-12

申请人： Andrew Robinson ,  Margaret Robinson ,  Andrew Richard Gorringe ,  Michael John Hudson ,  Karen Margaret Reddin

发明人： Andrew Robinson ,  Andrew Richard Gorringe ,  Michael John Hudson ,  Karen Margaret Reddin

IPC分类号： A61K39/095 ,  C07K14/22 ,  A61K35/74 ,  A61K38/16 ,  A61K39/00

摘要： A composition is provided comprising N. meningitidis outer membrane vesicles, wherein said outer membrane vesicles are enriched with at least one antigenic component. The composition is suitable for use in vaccines and for treatment of infection, particularly meningococcal infection, demonstrating a broad spectrum of protection. A number of preferred antigenic components are described and include antigenic proteins and proteoglycans derived from N. meningitidis.