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1.发明公开公开(公告)号：US20240316172A1
公开(公告)日：2024-09-26
申请号：US18425500
申请日：2024-01-29
发明人： Jeroen GEURTSEN , Jan Theunis POOLMAN , Kellen Cristhina FAE , Pieter Jan BURGHOUT , Eveline Marleen WEERDENBURG , Patricia IBARRA YON , Darren Robert ABBANAT , Stefan Jochen KEMMLER , Michael Thomas KOWARIK , Manuela MALLY , Veronica GAMBILLARA FONCK , Martin Edward BRAUN , Maria Paula CARRANZA SANDMEIER
CPC分类号： A61K39/0258 , A61P31/04 , A61P37/04 , C07K14/21 , C07K19/00 , C12N9/1051 , C12Y204/01 , A61K2039/575 , A61K2039/6037
摘要： A bioconjugate of an E. coli glucosylated O4 antigen polysaccharide covalently linked to a carrier protein and compositions thereof are provided. Also provided are recombinant host cells for producing the bioconjugate, and methods of producing the bioconjugate using the recombinant host cells. The recombinant host cells contain a nucleic acid encoding a glucosyl transferase capable of modifying the E. coli O4 antigen with glucose branching to produce the glucosylated O4 antigen polysaccharide. Bioconjugates of an E. coli glucosylated O4 antigen polysaccharide described herein can be used alone or in combination with one or more additional E. coli O-antigen polysaccharides to induce antibodies against an E. coli glucosylated antigen, and to vaccinate a subject against extra-intestinal pathogenic E. coli (ExPEC).
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公开(公告)号：US20230248820A1
公开(公告)日：2023-08-10
申请号：US16605238
申请日：2018-04-18
IPC分类号： A61K39/245 , C07K14/005 , A61K47/64
CPC分类号： A61K39/245 , C07K14/005 , A61K47/646 , C12N2710/16122 , C12N2710/16134 , C12N2710/16152
摘要： Described are mutant, human cytomegalovirus (HCMV) pentamer complex polypeptides, methods of making them, and their use in HCMV protein complexes and compositions. In particular, the use of the modified HCMV polypeptides to stabilize HCMV complexes or unmask a pentamer epitope is described.
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公开(公告)号：US11590243B2
公开(公告)日：2023-02-28
申请号：US16478232
申请日：2018-01-25
摘要： The present invention relates to the formulation of adenoviral vectors in sorbitol containing compositions in combination with a further amorphous sugar, its formulation as well as a method for obtaining a dried composition.
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公开(公告)号：US11285205B2
公开(公告)日：2022-03-29
申请号：US16078196
申请日：2017-03-02
IPC分类号： A61K39/145 , C07K14/005 , A61K39/12 , A61P31/16 , C12N15/62 , A61K39/00
摘要： The present invention relates to novel influenza antigens, novel immunogenic or vaccine compositions, as well as to uses of and to methods for producing said antigens and compositions. In particular, the invention relates to recombinant forms of hemagglutinin (HA) and their use in vaccine compositions for the prevention of influenza virus infections.
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公开(公告)号：US11241495B2
公开(公告)日：2022-02-08
申请号：US16179476
申请日：2018-11-02
发明人： Ralph Leon Biemans , Dominique Boutriau , Carine Capiau , Philippe Denoel , Pierre Duvivier , Jan Poolman
IPC分类号： A61K39/00 , A61K39/385 , A61K39/095 , C07H3/00 , A61K39/102 , A61K39/116 , A61K39/05 , A61K39/08 , A61K39/09 , A61K39/02 , A61K39/29 , A61K39/145 , C12N7/00 , A61K39/12
摘要： The present application discloses an immunogenic composition comprising N. meningitidis capsular polysaccharides from at least one of serogroups A, C, W135 and Y conjugated to a carrier protein to produce a N. meningitidis capsular polysaccharide conjugate, wherein the average size of each N. meningitidis polysaccharide is above 50 kDa.
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公开(公告)号：US11167028B2
公开(公告)日：2021-11-09
申请号：US16212245
申请日：2018-12-06
发明人： Luis Brito , Michelle Chan , Andrew Geall , Derek O'Hagan
IPC分类号： A61K39/39 , A61K9/107 , A61K47/06 , A61K47/24 , A61K39/12 , A61K39/155 , A61K39/245 , A61K47/02 , A61K47/12 , A61K47/22 , A61K47/26 , A61K47/34 , C12N7/00 , A61K39/00
摘要： This invention generally relates to cationic oil-in-water emulsions that contain high concentrations of cationic lipids and have a defined oil:lipid ratio. The cationic lipid can interact with the negatively charged molecule thereby anchoring the molecule to the emulsion particles. The cationic emulsions described herein are useful for delivering negatively charged molecules, such as nucleic acid molecules to cells, and for formulating nucleic acid-based vaccines.
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公开(公告)号：US11135287B2
公开(公告)日：2021-10-05
申请号：US16295563
申请日：2019-03-07
发明人： Luis Brito , Andrew Geall , Derek O'Hagan , Manmohan Singh
IPC分类号： A61K39/395 , A61K39/385 , A61K39/39 , A61K9/107 , A61K39/00
摘要： This invention generally relates to cationic oil-in-water emulsions that can be used to deliver negatively charged molecules, such as an RNA molecule. The emulsion particles comprise an oil core and a cationic lipid. The cationic lipid can interact with the negatively charged molecule thereby anchoring the molecule to the emulsion particles. The cationic emulsions described herein are particularly suitable for delivering nucleic acid molecules (such as an RNA molecule encoding an antigen) to cells and formulating nucleic acid-based vaccines.
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公开(公告)号：US20210269486A1
公开(公告)日：2021-09-02
申请号：US16467569
申请日：2017-12-08
IPC分类号： C07K14/005 , A61K39/39 , A61K39/205 , C12N15/86 , A61P31/14 , A61K39/21 , A61P31/18 , A61K39/12
摘要： The invention provides adenoviral vectors comprising transgenes encoding Lyssaviral antigens. The vectors can be used to produce vaccines for the prophylaxis, amelioration and treatment of diseases caused by Lyssaviral diseases, e.g., rabies.
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公开(公告)号：US10646564B2
公开(公告)日：2020-05-12
申请号：US16281567
申请日：2019-02-21
发明人： Ralph Leon Biemans , Nathalie Marie-Josephe Garcon , Philippe Vincent Hermand , Jan Poolman , Marcelle Paulette Van Mechelen
摘要： The present invention discloses an immunogenic composition comprising S. pneumoniae capsular saccharide conjugates from serotypes 19A and 19F wherein 19A is conjugated to a first bacterial toxoid and 19F is conjugated to a second bacterial toxoid. Vaccines, methods of making vaccines and uses of the vaccines are also described.
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公开(公告)号：US10548963B2
公开(公告)日：2020-02-04
申请号：US16046505
申请日：2018-07-26
IPC分类号： A61K39/085 , A61K39/116 , A61K39/00 , C07K16/12 , A61K47/64
摘要： The present application relates to immunogenic compositions comprising a mixture of staphylococcal antigens which combines antigen having different functions, for instance, combinations including a staphylococcal extracellular component binding protein and a staphylococcal transporter protein or a staphylococcal extracellular component binding protein and a staphylococcal regulator of virulence or toxin or a staphylococcal transporter protein and a staphylococcal regulator of virulence or toxin. Vaccines, methods of treatment, uses of and processes to make a staphylococcal vaccine are also described.
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