-
公开(公告)号：US09265840B2
公开(公告)日：2016-02-23
申请号：US14202419
申请日：2014-03-10
CPC分类号： A61K47/48261 , A61K39/092 , A61K47/61 , A61K47/6415 , A61K47/646 , A61K2039/6037 , A61K2039/62
摘要： Process for conjugation of bacterial saccharides including Streptococcus pneumoniae and Haemophilus influenzae saccharides by reductive amination are provided herein.
摘要翻译： 本文提供了通过还原胺化将包括肺炎链球菌和流感嗜血杆菌糖在内的细菌糖共轭的方法。
-
公开(公告)号：US20190262447A1
公开(公告)日：2019-08-29
申请号：US16281567
申请日：2019-02-21
发明人： Ralph Leon Biemans , Nathalie Marie-Josephe Garcon , Philippe Vincent Hermand , Jan Poolman , Marcelle Paulette Van Mechelen
IPC分类号： A61K39/385 , A61K47/61 , A61K47/64 , A61K39/09
摘要： The present invention discloses an immunogenic composition comprising S. pneumoniae capsular saccharide conjugates from serotypes 19A and 19F wherein 19A is conjugated to a first bacterial toxoid and 19F is conjugated to a second bacterial toxoid. Vaccines, methods of making vaccines and uses of the vaccines are also described.
-
公开(公告)号：US10279033B2
公开(公告)日：2019-05-07
申请号：US14987770
申请日：2016-01-05
发明人： Ralph Leon Biemans , Nathalie Marie-Josephe Garcon , Philippe Vincent Hermand , Jan Poolman , Marcelle Paulette Van Mechelen
摘要： The present invention discloses an immunogenic composition comprising S. pneumoniae capsular saccharide conjugates from serotypes 19A and 19F wherein 19A is conjugated to a first bacterial toxoid and 19F is conjugated to a second bacterial toxoid. Vaccines, methods of making vaccines and uses of the vaccines are also described.
-
公开(公告)号：US10166287B2
公开(公告)日：2019-01-01
申请号：US15691440
申请日：2017-08-30
发明人： Ralph Leon Biemans , Dominique Boutriau , Carine Capiau , Philippe Denoel , Pierre Duvivier , Jan Poolman
IPC分类号： A61K39/00 , A61K39/385 , A61K39/095 , A61K39/102 , A61K39/116 , C07H3/00 , A61K39/05 , A61K39/08 , A61K39/09 , A61K39/02 , A61K39/29 , A61K39/145 , C12N7/00 , A61K39/12
摘要： present application discloses an immunogenic composition comprising N. meningitidis capsular polysaccharides from at least one of serogroups A, C, W135 and Y conjugated to a carrier protein to produce a N. meningitidis capsular polysaccharide conjugate, wherein the average size of each N. meningitidis polysaccharide is above 50 kDa.
-
公开(公告)号：US20170065714A1
公开(公告)日：2017-03-09
申请号：US15265597
申请日：2016-09-14
发明人： Ralph Leon Biemans , Dominique Boutriau , Carine Capiau , Philippe Denoel , Pierre Duvivier , Jan Poolman
IPC分类号： A61K39/385 , A61K39/145 , C12N7/00 , A61K39/095
CPC分类号： A61K39/385 , A61K39/0017 , A61K39/0018 , A61K39/05 , A61K39/08 , A61K39/092 , A61K39/095 , A61K39/099 , A61K39/102 , A61K39/116 , A61K39/12 , A61K39/145 , A61K39/292 , A61K2039/545 , A61K2039/55 , A61K2039/575 , A61K2039/6037 , A61K2039/62 , A61K2039/627 , A61K2039/70 , C07H3/00 , C12N7/00 , C12N2730/10134 , C12N2760/16234 , C12N2760/16271 , C12N2770/32634 , Y02A50/466 , Y02A50/484
摘要： The present application discloses an immunogenic composition comprising at least 2 different N. meningitidis capsular saccharides, wherein one or more is/are selected from a first group consisting of MenA, MenC, MenY and MenW which is/are conjugated through a linker to a carrier protein(s), and one or more different saccharides is/are selected from a second group consisting of MenA, MenC, MenY and MenW which is/are directly conjugated to a carrier protein(s).
摘要翻译： 本申请公开了一种免疫原性组合物，其包含至少2种不同的脑膜炎奈瑟氏球菌荚膜糖苷，其中一种或多种选自MenA，MenC，MenY和MenW组成的第一组，其通过接头与载体共轭 蛋白质和一种或多种不同的糖选自由与载体蛋白直接缀合的MenA，MenC，MenY和MenW组成的第二组。
-
公开(公告)号：US11241495B2
公开(公告)日：2022-02-08
申请号：US16179476
申请日：2018-11-02
发明人： Ralph Leon Biemans , Dominique Boutriau , Carine Capiau , Philippe Denoel , Pierre Duvivier , Jan Poolman
IPC分类号： A61K39/00 , A61K39/385 , A61K39/095 , C07H3/00 , A61K39/102 , A61K39/116 , A61K39/05 , A61K39/08 , A61K39/09 , A61K39/02 , A61K39/29 , A61K39/145 , C12N7/00 , A61K39/12
摘要： The present application discloses an immunogenic composition comprising N. meningitidis capsular polysaccharides from at least one of serogroups A, C, W135 and Y conjugated to a carrier protein to produce a N. meningitidis capsular polysaccharide conjugate, wherein the average size of each N. meningitidis polysaccharide is above 50 kDa.
-
公开(公告)号：US10646564B2
公开(公告)日：2020-05-12
申请号：US16281567
申请日：2019-02-21
发明人： Ralph Leon Biemans , Nathalie Marie-Josephe Garcon , Philippe Vincent Hermand , Jan Poolman , Marcelle Paulette Van Mechelen
摘要： The present invention discloses an immunogenic composition comprising S. pneumoniae capsular saccharide conjugates from serotypes 19A and 19F wherein 19A is conjugated to a first bacterial toxoid and 19F is conjugated to a second bacterial toxoid. Vaccines, methods of making vaccines and uses of the vaccines are also described.
-
公开(公告)号：US10245317B2
公开(公告)日：2019-04-02
申请号：US15265597
申请日：2016-09-14
发明人： Ralph Leon Biemans , Dominique Boutriau , Carine Capiau , Philippe Denoel , Pierre Duvivier , Jan Poolman
IPC分类号： A61K39/00 , A61K39/02 , C07H3/00 , C12N7/00 , A61K39/08 , A61K39/09 , A61K39/385 , A61K39/095 , A61K39/102 , A61K39/116 , A61K39/05 , A61K39/29 , A61K39/145 , A61K39/12
摘要： The present application discloses an immunogenic composition comprising at least 2 different N. meningitidis capsular saccharides, wherein one or more is/are selected from a first group consisting of MenA, MenC, MenY and MenW which is/are conjugated through a linker to a carrier protein(s), and one or more different saccharides is/are selected from a second group consisting of MenA, MenC, MenY and MenW which is/are directly conjugated to a carrier protein(s).
-
公开(公告)号：US20180064806A1
公开(公告)日：2018-03-08
申请号：US15691440
申请日：2017-08-30
发明人： Ralph Leon Biemans , Dominique Boutriau , Carine Capiau , Philippe Denoel , Pierre Duvivier , Jan Poolman
IPC分类号： A61K39/385 , A61K39/00 , A61K39/05 , A61K39/08 , A61K39/09 , A61K39/095 , A61K39/02 , A61K39/102 , A61K39/116 , A61K39/145 , A61K39/29 , C07H3/00 , C12N7/00
CPC分类号： A61K39/385 , A61K39/0017 , A61K39/0018 , A61K39/05 , A61K39/08 , A61K39/092 , A61K39/095 , A61K39/099 , A61K39/102 , A61K39/116 , A61K39/12 , A61K39/145 , A61K39/292 , A61K2039/545 , A61K2039/55 , A61K2039/575 , A61K2039/6037 , A61K2039/62 , A61K2039/627 , A61K2039/70 , C07H3/00 , C12N7/00 , C12N2730/10134 , C12N2760/16234 , C12N2760/16271 , C12N2770/32634 , Y02A50/466 , Y02A50/484
摘要： present application discloses an immunogenic composition comprising N. meningitidis capsular polysaccharides from at least one of serogroups A, C, W135 and Y conjugated to a carrier protein to produce a N. meningitidis capsular polysaccharide conjugate, wherein the average size of each N. meningitidis polysaccharide is above 50 kDa.
-
公开(公告)号：US09265839B2
公开(公告)日：2016-02-23
申请号：US14202119
申请日：2014-03-10
CPC分类号： A61K47/48261 , A61K39/092 , A61K47/61 , A61K47/6415 , A61K47/646 , A61K2039/6037 , A61K2039/62
摘要： Process for conjugation of bacterial saccharides including Streptococcus pneumoniae and Haemophilus influenzae saccharides by reductive amination are provided herein.
-
-
-
-
-
-
-
-
-
搜索结果
15 条记录 (耗时 0.024 秒)
