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    PROPIONIBACTERIUM ACNES PROPHYLACTIC AND THERAPEUTIC IMMUNE TREATMENT
    1.
    发明公开
    PROPIONIBACTERIUM ACNES PROPHYLACTIC AND THERAPEUTIC IMMUNE TREATMENT 审中-公开

    公开(公告)号：US20240139302A1

    公开(公告)日：2024-05-02

    申请号：US17801099

    申请日：2021-02-22

    Applicant: Origimm Biotechnology GmbH

    Inventor： Sanja Selak ,  Christine Triska ,  Manfired Schuster ,  Johannes Söllner ,  Bernhard Roppenser ,  Theresa Weinhäupl ,  Max Rössler

    IPC: A61K39/05 ,  A61P17/10 ,  A61P31/04 ,  C07K14/195

    CPC classification number: A61K39/05 ,  A61P17/10 ,  A61P31/04 ,  C07K14/195

    Abstract: The present invention discloses a vaccine comprising one or more of Dermatan sulfate-binding adhesin 1 of P. acnes (DsA1 polypeptide), Dermatan sulfate-binding adhesin 2 of P. acnes (DsA2 polypeptide), and putative iron-transport protein (PITP) polypeptide of P. acnes, and/or a fragment and/or derivative of DsA1 and/or DsA2 and/or PITP, wherein the DsA1 polypeptide and the DsA2 polypeptide comprise from N- to C-terminus an N-terminal swapping region (“NSR”), a first conserved sub-domain (“CSD1”), a first swapping region (“SR1”), a second conserved sub-domain (“CSD2”), a second swapping region (“SR2”), a third conserved sub-domain (“CSD3”), a Pro-Thr repeat containing region (“PT repeat region”), and a C-terminal region (“CTR”), and wherein the PITP polypeptide comprises from N- to C-terminus an extended neocarzinostatin family domain (“ENFD”), a first swapping region (“SR1”), a heme-binding domain (“HbD”), a second swapping region (“SR2”) including the C-terminal LPXTG motif, and a hydrophobic C-terminal region (“hLAR”).

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