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公开(公告)号:US20180104324A1
公开(公告)日:2018-04-19
申请号:US15819312
申请日:2017-11-21
Applicant: GLAXOSMITHKLINE BIOLOGICALS SA
Inventor: Guido Grandi , Immaculada Margarit Y Ros , Domenico Maione
IPC: A61K39/09 , A61K39/13 , A61K9/00 , A61K39/00 , A61K39/05 , A61K39/08 , A61K39/02 , C12N7/00 , A61K39/12
CPC classification number: A61K39/092 , A61K9/0019 , A61K39/0018 , A61K39/05 , A61K39/08 , A61K39/099 , A61K39/12 , A61K39/13 , A61K47/646 , A61K2039/55 , A61K2039/55505 , A61K2039/6037 , A61K2039/70 , C12N7/00 , C12N2770/32334 , C12N2770/32634 , Y02A50/466
Abstract: Methods for raising an immune response in a mammal, by administration of an immunogenic composition comprising capsular saccharides from Streptococcus agalactiae (GBS) serotypes conjugated to carrier proteins.
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公开(公告)号:US10245310B2
公开(公告)日:2019-04-02
申请号:US15501474
申请日:2015-08-05
Applicant: GLAXOSMITHKLINE BIOLOGICALS SA
Inventor: Francesco Berti , Roberta Cozzi , Domenico Maione , Cira Daniela Rinaudo , Immaculada Margarit Y Ros , Guido Grandi
IPC: A61K39/09 , A61K39/095 , A61K47/48
Abstract: The invention provides a conjugate comprising an antigen and a carrier molecule, wherein the carrier molecule comprises a BP-2a antigen and a spb1 antigen. BP-2a and spb1 are Streptococcus agalactiae antigens. The conjugate may be used in a method for raising an immune response in a mammal, the method comprising administering the conjugate to the mammal. Also provided are pharmaceutical compositions, particularly vaccines, comprising the conjugate.
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公开(公告)号:US10086060B2
公开(公告)日:2018-10-02
申请号:US15630679
申请日:2017-06-22
Applicant: GlaxoSmithKline Biologicals SA
Inventor: Guido Grandi , Domenico Maione , Cira Daniela Rinaudo
Abstract: The invention provides proteins and compositions for the treatment and prevention of Streptococcus agalactiae (Group B streptococcus; GBS).
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公开(公告)号:US09855325B2
公开(公告)日:2018-01-02
申请号:US14424370
申请日:2013-10-03
Applicant: GlaxoSmithKline Biologicals SA
Inventor: Guido Grandi , Immaculada Margarit Y Ros , Domenico Maione
IPC: A61K39/09 , A61K39/00 , A61K39/05 , A61K39/08 , A61K39/02 , A61K39/13 , A61K39/12 , C12N7/00 , A61K9/00 , A61K47/64
CPC classification number: A61K39/092 , A61K9/0019 , A61K39/0018 , A61K39/05 , A61K39/08 , A61K39/099 , A61K39/12 , A61K39/13 , A61K47/646 , A61K2039/55 , A61K2039/55505 , A61K2039/6037 , A61K2039/70 , C12N7/00 , C12N2770/32334 , C12N2770/32634 , Y02A50/466
Abstract: The invention provides an immunogenic composition comprising: a) a conjugate that is a capsular saccharide from GBS serotype Ia conjugated to a carrier protein; b) a conjugate that is a capsular saccharide from GBS serotype Ib conjugated to a carrier protein; c) a conjugate that is a capsular saccharide from GBS serotype III conjugated to a carrier protein; d) a conjugate that is a capsular saccharide from GBS serotype II conjugated to a carrier protein; and e) a conjugate that is a capsular saccharide from GBS serotype V conjugated to a carrier protein.
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公开(公告)号:US20170296645A1
公开(公告)日:2017-10-19
申请号:US15630679
申请日:2017-06-22
Applicant: GlaxoSmithKline Biologicals SA
Inventor: Guido Grandi , Domenico Maione , Cira Daniela Rinaudo
CPC classification number: A61K39/092 , A61K2039/55 , A61K2039/57 , A61K2039/575 , C07K14/315 , C07K16/1275 , C07K2317/734 , C07K2319/40
Abstract: The invention provides proteins and compositions for the treatment and prevention of Streptococcus agalactiae (Group B streptococcus; GBS)
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公开(公告)号:US20160362457A1
公开(公告)日:2016-12-15
申请号:US15252930
申请日:2016-08-31
Applicant: GLAXOSMITHKLINE BIOLOGICALS SA
Inventor: Guido Grandi , Domenico Maione , Cira Daniela Rinaudo
IPC: C07K14/315 , A61K39/09
CPC classification number: A61K39/092 , A61K2039/55 , A61K2039/57 , A61K2039/575 , C07K14/315 , C07K16/1275 , C07K2317/734 , C07K2319/40
Abstract: The invention provides proteins and compositions for the treatment and prevention of Streptococcus agalactiae (Group B streptococcus; GBS)
Abstract translation: 本发明提供了用于治疗和预防无乳链球菌(B族链球菌; GBS)的蛋白质和组合物,
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公开(公告)号:US09458229B2
公开(公告)日:2016-10-04
申请号:US14631456
申请日:2015-02-25
Applicant: GLAXOSMITHKLINE BIOLOGICALS SA
Inventor: Guido Grandi , Domenico Maione , Cira Daniela Rinaudo
IPC: A61K39/09 , C07K14/315 , C07H21/04 , C07K16/12
CPC classification number: A61K39/092 , A61K2039/55 , A61K2039/57 , A61K2039/575 , C07K14/315 , C07K16/1275 , C07K2317/734 , C07K2319/40
Abstract: The invention provides proteins and compositions for the treatment and prevention of Streptococcus agalactiae (Group B streptococcus; GBS).
Abstract translation: 本发明提供了用于治疗和预防无乳链球菌(B族链球菌; GBS)的蛋白质和组合物。
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公开(公告)号:US10286055B2
公开(公告)日:2019-05-14
申请号:US15819312
申请日:2017-11-21
Applicant: GLAXOSMITHKLINE BIOLOGICALS SA
Inventor: Guido Grandi , Immaculada Margarit Y Ros , Domenico Maione
IPC: A61K9/00 , C12N7/00 , A61K39/09 , A61K39/00 , A61K39/05 , A61K39/08 , A61K39/02 , A61K39/13 , A61K39/12 , A61K47/64
Abstract: Methods for raising an immune response in a mammal, by administration of an immunogenic composition comprising capsular saccharides from Streptococcus agalactiae (GBS) serotypes conjugated to carrier proteins.
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公开(公告)号:US09855324B2
公开(公告)日:2018-01-02
申请号:US14424362
申请日:2013-10-03
Applicant: GlaxoSmithKline Biologicals SA
Inventor: Mario Contorni , Guido Grandi , Domenico Maione , Immaculada Margarit Y Ros
IPC: A61K39/09 , A61K39/00 , A61K39/05 , A61K39/08 , A61K39/02 , A61K39/13 , A61K39/12 , C12N7/00 , A61K9/00 , A61K47/64
CPC classification number: A61K39/092 , A61K9/0019 , A61K39/0018 , A61K39/05 , A61K39/08 , A61K39/099 , A61K39/12 , A61K39/13 , A61K47/646 , A61K2039/55 , A61K2039/55505 , A61K2039/6037 , A61K2039/70 , C12N7/00 , C12N2770/32334 , C12N2770/32634 , Y02A50/466
Abstract: The invention provides an immunogenic composition comprising one or more GBS conjugates and one or more antigens selected from: a) cellular or acellular pertussis antigen, b) a tetanus toxoid, c) a diphtheria toxoid and d) an inactivated polio virus antigen, wherein each GBS conjugate is a group B streptococcus capsular saccharide conjugated to a carrier protein. The invention also provides a method for raising an immune response in a patient, comprising the step of administering to the patient a composition of the invention.
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公开(公告)号:US09725488B2
公开(公告)日:2017-08-08
申请号:US15252930
申请日:2016-08-31
Applicant: GLAXOSMITHKLINE BIOLOGICALS SA
Inventor: Guido Grandi , Domenico Maione , Cira Daniela Rinaudo
IPC: A61K39/09 , C07K14/315 , C07K16/12 , A61K39/00
CPC classification number: A61K39/092 , A61K2039/55 , A61K2039/57 , A61K2039/575 , C07K14/315 , C07K16/1275 , C07K2317/734 , C07K2319/40
Abstract: The invention provides proteins and compositions for the treatment and prevention of Streptococcus agalactiae (Group B streptococcus; GBS).