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公开(公告)号：US20150307850A1
公开(公告)日：2015-10-29
申请号：US14649669
申请日：2013-12-04
申请人： Tong-ming FU , Dai WANG , Danilo CASIMIRO , Daniel FREED , Fengsheng LI , MERCK SHARP & DOHME CORP.
发明人： Tong-Ming Fu , Dai Wang , Danilo Casimiro , Daniel C. Freed , Fengsheng Li
IPC分类号： C12N7/00 , A61K39/245 , C07K14/005
CPC分类号： C12N7/00 , A61K39/12 , A61K39/21 , A61K39/245 , A61K2039/5256 , C07K14/005 , C12N15/86 , C12N2710/16121 , C12N2710/16122 , C12N2710/16134 , C12N2710/16141 , C12N2710/16152 , C12N2710/16162 , C12N2740/16234
摘要： The present invention relates to a cytomegalovirus (CMV) which has been recombinantly altered to express a heterologous polypeptide and to allow for external control of viral replication. The heterologous polypeptide may be a polypeptide of interest such as an antigen, antibody or immune modulator. The CMV vectors of the invention are replication defective, or chemically controllable replication capable, or replication competent. The present invention also relates to uses of the CMV vectors such as inducing an immune response to an antigen or expressing an antibody or immune modulator in vivo. Compositions comprising the CMV expressing the heterologous polypeptide are also encompassed by the present invention.
摘要翻译： 本发明涉及重组改变以表达异源多肽并允许外部控制病毒复制的巨细胞病毒（CMV）。 异源多肽可以是感兴趣的多肽，例如抗原，抗体或免疫调节剂。 本发明的CMV载体是复制缺陷的，或具有化学上可控的复制能力或复制能力的。 本发明还涉及CMV载体的用途，例如在体内诱导对抗原的免疫应答或表达抗体或免疫调节剂。 包含表达异源多肽的CMV的组合物也包括在本发明中。
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公开(公告)号：US09078867B2
公开(公告)日：2015-07-14
申请号：US13695668
申请日：2011-05-05
IPC分类号： A61K39/245 , C12N7/00 , C12N15/38 , A61K39/00
CPC分类号： A61K39/245 , A61K39/12 , A61K2039/525 , A61K2039/5254 , A61K2039/575 , C12N7/00 , C12N2710/16111 , C12N2710/16121 , C12N2710/16134 , C12N2710/16152 , C12N2710/16162 , C12N2710/16171 , C12N2710/16511 , C12N2830/003
摘要： The present invention is related to a beta-herpesvirus, wherein the beta-herpesvirus is spread-deficient.
摘要翻译： 本发明涉及β-疱疹病毒，其中β-疱疹病毒是扩散缺陷型的。
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公开(公告)号：US20230248820A1
公开(公告)日：2023-08-10
申请号：US16605238
申请日：2018-04-18
IPC分类号： A61K39/245 , C07K14/005 , A61K47/64
CPC分类号： A61K39/245 , C07K14/005 , A61K47/646 , C12N2710/16122 , C12N2710/16134 , C12N2710/16152
摘要： Described are mutant, human cytomegalovirus (HCMV) pentamer complex polypeptides, methods of making them, and their use in HCMV protein complexes and compositions. In particular, the use of the modified HCMV polypeptides to stabilize HCMV complexes or unmask a pentamer epitope is described.
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公开(公告)号：US20130202638A1
公开(公告)日：2013-08-08
申请号：US13695668
申请日：2011-05-05
IPC分类号： A61K39/245
CPC分类号： A61K39/245 , A61K39/12 , A61K2039/525 , A61K2039/5254 , A61K2039/575 , C12N7/00 , C12N2710/16111 , C12N2710/16121 , C12N2710/16134 , C12N2710/16152 , C12N2710/16162 , C12N2710/16171 , C12N2710/16511 , C12N2830/003
摘要： The present invention is related to a beta-herpesvirus, wherein the beta-herpesvirus is spread-deficient.
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公开(公告)号：US20150306210A1
公开(公告)日：2015-10-29
申请号：US14734415
申请日：2015-06-09
IPC分类号： A61K39/245 , C12N7/00
CPC分类号： A61K39/245 , A61K39/12 , A61K2039/525 , A61K2039/5254 , A61K2039/575 , C12N7/00 , C12N2710/16111 , C12N2710/16121 , C12N2710/16134 , C12N2710/16152 , C12N2710/16162 , C12N2710/16171 , C12N2710/16511 , C12N2830/003
摘要： The present invention is related to a beta-herpesvirus, wherein the beta-herpesvirus is spread-deficient.
摘要翻译： 本发明涉及β-疱疹病毒，其中β-疱疹病毒是扩散缺陷型的。
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公开(公告)号：US20020102536A1
公开(公告)日：2002-08-01
申请号：US09990141
申请日：2001-11-20
IPC分类号： C12Q001/70 , A61K039/245 , A61K039/255 , A61K039/265 , A61K039/27 , C12N007/00 , C12N007/01 , C12N007/02 , C12N005/00 , C12N005/02
CPC分类号： C07K14/005 , A61K2039/5254 , C12N7/00 , C12N2710/16122 , C12N2710/16152 , C12N2710/16161
摘要： Culture of human oranimal herpesviruses, e.g. disabled mutant herpesviruses, can be carried out on primary cells which have been made recombinant so as to express a first gene that extends their culturable life and a second gene derived from the virus. The virus products can be used in vaccines or gene delivery to cells.
摘要翻译： 人类神经疱疹病毒的培养，例如 残基突变疱疹病毒可以在已经重组的原代细胞上进行，以便表达延长其培养寿命的第一个基因和来自该病毒的第二个基因。 病毒产品可用于疫苗或基因递送至细胞。
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