公开(公告)号：US20110008369A1

公开(公告)日：2011-01-13

申请号：US12922066

申请日：2009-03-03

Applicant: Adam C. Finnefrock ,  Tong-Ming Fu ,  Daniel C. Freed ,  Danilo R. Casimiro ,  Fengsheng Li ,  Aimin Tang

Inventor： Adam C. Finnefrock ,  Tong-Ming Fu ,  Daniel C. Freed ,  Danilo R. Casimiro ,  Fengsheng Li ,  Aimin Tang

IPC: A61K39/395 ,  C07K16/18 ,  A61P37/04

CPC classification number: C07K16/2896 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/92 ,  C07K2319/30

Abstract: The present invention features PD-1 binding proteins, a subset of which inhibits binding of PD-L1 to the PD-1 receptor. These binding proteins can be employed to modulate the immune system through the manipulation of the PD-1 signaling pathway, enhancing host immunity to treat infections and cancer.

Abstract translation: 本发明的特征在于PD-1结合蛋白，其一部分抑制PD-L1与PD-1受体的结合。 这些结合蛋白可用于通过操纵PD-1信号传导途径来调节免疫系统，增强宿主免疫治疗感染和癌症。

公开(公告)号：US20150307850A1

公开(公告)日：2015-10-29

申请号：US14649669

申请日：2013-12-04

Applicant: Tong-ming FU ,  Dai WANG ,  Danilo CASIMIRO ,  Daniel FREED ,  Fengsheng LI ,  MERCK SHARP & DOHME CORP.

Inventor： Tong-Ming Fu ,  Dai Wang ,  Danilo Casimiro ,  Daniel C. Freed ,  Fengsheng Li

IPC: C12N7/00 ,  A61K39/245 ,  C07K14/005

CPC classification number: C12N7/00 ,  A61K39/12 ,  A61K39/21 ,  A61K39/245 ,  A61K2039/5256 ,  C07K14/005 ,  C12N15/86 ,  C12N2710/16121 ,  C12N2710/16122 ,  C12N2710/16134 ,  C12N2710/16141 ,  C12N2710/16152 ,  C12N2710/16162 ,  C12N2740/16234

Abstract: The present invention relates to a cytomegalovirus (CMV) which has been recombinantly altered to express a heterologous polypeptide and to allow for external control of viral replication. The heterologous polypeptide may be a polypeptide of interest such as an antigen, antibody or immune modulator. The CMV vectors of the invention are replication defective, or chemically controllable replication capable, or replication competent. The present invention also relates to uses of the CMV vectors such as inducing an immune response to an antigen or expressing an antibody or immune modulator in vivo. Compositions comprising the CMV expressing the heterologous polypeptide are also encompassed by the present invention.

Abstract translation: 本发明涉及重组改变以​​表达异源多肽并允许外部控制病毒复制的巨细胞病毒（CMV）。 异源多肽可以是感兴趣的多肽，例如抗原，抗体或免疫调节剂。 本发明的CMV载体是复制缺陷的，或具有化学上可控的复制能力或复制能力的。 本发明还涉及CMV载体的用途，例如在体内诱导对抗原的免疫应答或表达抗体或免疫调节剂。 包含表达异源多肽的CMV的组合物也包括在本发明中。

公开(公告)号：US08168757B2

公开(公告)日：2012-05-01

申请号：US12922066

申请日：2009-03-03

Applicant: Adam C. Finnefrock ,  Tong-Ming Fu ,  Daniel C. Freed ,  Danilo R. Casimiro ,  Fengsheng Li ,  Aimin Tang

Inventor： Adam C. Finnefrock ,  Tong-Ming Fu ,  Daniel C. Freed ,  Danilo R. Casimiro ,  Fengsheng Li ,  Aimin Tang

IPC: C07K16/00

CPC classification number: C07K16/2896 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/92 ,  C07K2319/30

Abstract: The present invention features PD-1 binding proteins, a subset of which inhibits binding of PD-L1 to the PD-1 receptor. These binding proteins can be employed to modulate the immune system through the manipulation of the PD-1 signaling pathway, enhancing host immunity to treat infections and cancer.

Abstract translation: 本发明的特征在于PD-1结合蛋白，其一部分抑制PD-L1与PD-1受体的结合。 这些结合蛋白可用于通过操纵PD-1信号传导途径来调节免疫系统，增强宿主免疫治疗感染和癌症。

公开(公告)号：US20050024334A1

公开(公告)日：2005-02-03

申请号：US10632041

申请日：2003-08-01

Applicant: Fengsheng Li ,  Wenying Meng ,  Mengzhan Li

Inventor： Fengsheng Li ,  Wenying Meng ,  Mengzhan Li

IPC: G06F3/033 ,  G09G5/08

CPC classification number: G06F3/03543

Abstract: A bristled computer mouse is described. The new typed mouse have sparsely populated bristles or teeth on the back, which are meant to facilitate dissipating of heat accumulated under user's palm by prolonged use, and to supply passive or active massaging effects to the user's palm by just holding and using. This new mouse can provide relaxation, stimulation and comfort by releasing the heat, the numbness and fatigue of the palm and hand. By its appearance this type of mouse can also be called a computer hedgehog.

Abstract translation: 描述了一个刚毛的电脑鼠标。 新型鼠标背面有稀疏的刷毛或齿，这意味着通过长时间使用便于消耗用户手掌下积聚的热量，并通过持有和使用为用户的手掌提供被动或主动的按摩效果。 这种新型鼠标可以通过释放热量，手掌和手掌的麻木和疲劳来提供放松，刺激和舒适。 通过其外观，这种类型的鼠标也可以称为电脑刺猬。