公开(公告)号：US20240174986A1

公开(公告)日：2024-05-30

申请号：US18284793

申请日：2022-03-28

申请人： Rational Vaccines, Inc.

发明人： Agustin FERNANDEZ ,  Edward GERSHBURG ,  Paul PREDKI

IPC分类号： C12N7/00 ,  A61K39/00 ,  A61K39/245 ,  A61P31/22 ,  C07K14/005

CPC分类号： C12N7/00 ,  A61K39/245 ,  A61P31/22 ,  C07K14/005 ,  A61K2039/522 ,  C12N2710/16621 ,  C12N2710/16622 ,  C12N2710/16634

摘要： Compositions and methods related to a mutant herpesvirus and a mutant ICP0 protein. Vaccine compositions comprising the mutant herpesvirus and/or mutant ICP0 protein. Methods of treatment using the mutant herpesvirus and/or mutant ICP0 protein.

公开(公告)号：US20240156972A1

公开(公告)日：2024-05-16

申请号：US18547714

申请日：2022-02-24

申请人： McMaster University

发明人： Anthony RULLO ,  Yonghong WAN ,  Harrison McCann ,  Benjamin LAKE

IPC分类号： A61K47/64 ,  A61K35/763 ,  A61K47/54 ,  A61K47/60 ,  A61P35/00 ,  C07K14/005

CPC分类号： A61K47/64 ,  A61K35/763 ,  A61K47/545 ,  A61K47/60 ,  A61P35/00 ,  C07K14/005 ,  C12N2710/16622

摘要： The present disclosure relates generally to the field of cancer immunotherapy. More particularly, the present disclosure provides antibody recruitment molecules, pharmaceutical compositions comprising same and kits comprising same. The present disclosure also provides methods of treating cancer using the antibody recruitment molecules in combination with oncolytic virus therapy, and methods for enhancing the efficacy and/or reducing the toxicity of the oncolytic virus therapy.

公开(公告)号：US11883448B2

公开(公告)日：2024-01-30

申请号：US16985459

申请日：2020-08-05

申请人： University of Pittsburgh—Of the Commonwealth System of Higher Education

发明人： Hiroaki Uchida ,  Justus B. Cohen ,  Joseph C. Glorioso, III ,  Paola Grandi

IPC分类号： C12N15/00 ,  A61K35/763 ,  C12N7/00 ,  C07K14/005

CPC分类号： A61K35/763 ,  C07K14/005 ,  C12N7/00 ,  C07K2319/33 ,  C12N2710/16621 ,  C12N2710/16622 ,  C12N2710/16632 ,  C12N2710/16641 ,  C12N2710/16643 ,  C12N2710/16645 ,  C12N2710/16662 ,  C12N2710/16671

摘要： The present invention provides a recombinant oncolytic Herpes Simplex Virus (oHSV) comprising a non-HSV ligand specific for a molecule (protein, lipid, or carbohydrate determinant) present on the surface of a cell (such as a cancer cell) and one or more copies of one or more microRNA target sequences inserted into one or more HSV gene loci, preferably one or more HSV gene(s) required for replication of HSV in normal (i.e., non-cancerous) cells. The invention further provides stocks and pharmaceutical compositions comprising the inventive oHSV and methods for killing tumor cells employing the inventive oHSV.

公开(公告)号：US11752206B2

公开(公告)日：2023-09-12

申请号：US16494130

申请日：2018-03-15

申请人： ModernaTX, Inc.

发明人： Giuseppe Ciaramella ,  Shinu John ,  Andrew J. Bett ,  Danilo R. Casimiro ,  Dai Wang ,  Lan Zhang

IPC分类号： A61K39/245 ,  A61P31/22 ,  A61K9/00 ,  A61K9/51 ,  A61K39/39 ,  C07K14/005 ,  C12N7/00 ,  A61K47/69 ,  A61K39/00

CPC分类号： A61K39/245 ,  A61K9/0019 ,  A61K9/5123 ,  A61K9/5146 ,  A61K39/39 ,  A61K47/6929 ,  A61P31/22 ,  C07K14/005 ,  C12N7/00 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/55516 ,  A61K2039/70 ,  C07K2319/02 ,  C07K2319/40 ,  C12N2710/16622 ,  C12N2710/16634

摘要： Herpes simplex virus (HSV) ribonucleic acid (RNA) vaccines, as well as methods of using the vaccines and compositions comprising the vaccines. In a preferred embodiment, the vaccine is formulated as a lipid nanoparticle comprising at least one cationic lipid.

公开(公告)号：US11684670B2

公开(公告)日：2023-06-27

申请号：US17335548

申请日：2021-06-01

申请人： Albert Einstein College of Medicine

发明人： Betsy C. Herold ,  Clare Burn Aschner

IPC分类号： A61K39/245 ,  A61P31/22 ,  A61K9/00 ,  C12N7/00 ,  A61K39/00

CPC分类号： A61K39/245 ,  A61K9/0019 ,  A61P31/22 ,  C12N7/00 ,  A61K2039/54 ,  C12N2710/16621 ,  C12N2710/16622 ,  C12N2710/16634

摘要： Methods of vaccinating, immunizing and/or treating a subject against a herpes simplex virus infection or a disease caused by a herpes simplex virus infection comprise administering to the subject an effective amount of a HSV-2 single-cycle virus and an effective amount of a recombinant HSV-2 glycoprotein D, wherein the HSV-2 single-cycle virus comprises HSV-2 having a deletion of glycoprotein D-encoding gene in the genome and the HSV-2 is phenotypically complemented with an HSV-1 glycoprotein D on a lipid bilayer of the HSV-2.

公开(公告)号：US20190091327A1

公开(公告)日：2019-03-28

申请号：US16148414

申请日：2018-10-01

申请人： Board of Supervisors of Louisiana State University Agricultural and Mechanical College

发明人： Konstantin G. Kousoulas

IPC分类号： A61K39/245 ,  C12N7/00 ,  A61K39/12 ,  A61K39/00

CPC分类号： A61K39/245 ,  A61K39/12 ,  A61K2039/5254 ,  C12N7/00 ,  C12N2710/16622 ,  C12N2710/16634 ,  C12N2710/16662

摘要： The present invention provides vaccines for treating or preventing a herpes simplex virus infection and methods of using and making the vaccine. Further provided are recombinant herpes simplex virus genomes, recombinant viruses, and immunogenic compositions.

公开(公告)号：US20180305411A1

公开(公告)日：2018-10-25

申请号：US16020543

申请日：2018-06-27

申请人： Duke University ,  U.S. Army Medical Research and Material Command ,  Children's Medical Center Corporation

发明人： Jerome KIM ,  Stephen HARRISON ,  Barton F. HAYNES ,  Georgia D. TOMARAS ,  Nelson MICHAEL

IPC分类号： C07K14/005 ,  A61K39/12

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K39/12 ,  A61K39/21 ,  A61K2039/6075 ,  C07K16/1063 ,  C07K2317/21 ,  C07K2317/55 ,  C07K2317/92 ,  C07K2319/40 ,  C12N2710/16622 ,  C12N2740/16122 ,  C12N2740/16134

摘要： The present invention relates, in general, to human immunodeficiency virus (HIV), and in particular to a vaccine for HIV-1 and to methods of making and using same.

公开(公告)号：US20180133310A1

公开(公告)日：2018-05-17

申请号：US15717849

申请日：2017-09-27

申请人： Genocea Biosciences, Inc.

发明人： Seth Vollmer Hetherington

IPC分类号： A61K39/245 ,  A61P31/22 ,  A61K31/522 ,  A61K31/52

CPC分类号： A61K39/245 ,  A61K31/52 ,  A61K31/522 ,  A61K39/12 ,  A61K2039/545 ,  A61K2039/55511 ,  A61K2039/55577 ,  A61P31/22 ,  C07K14/035 ,  C12N7/04 ,  C12N2710/16622 ,  C12N2710/16634 ,  G01N33/56994 ,  G01N2333/035

摘要： The present disclosure provides, inter alia, certain combinations of immunogenic compositions (e.g., vaccines) against HSV-2 and antiviral therapy. The vaccines can be used therapeutically and/or prophylactically.

公开(公告)号：US20170274025A1

公开(公告)日：2017-09-28

申请号：US15616585

申请日：2017-06-07

申请人： University of Pittsburgh - Of the Commonwealth System of Higher Education

发明人： Hiroaki Uchida ,  Justus B. Cohen ,  Joseph C. Glorioso, III ,  Paola Grandi

IPC分类号： A61K35/763 ,  C07K14/005 ,  C12N7/00

CPC分类号： A61K35/763 ,  C07K14/005 ,  C07K2319/33 ,  C12N7/00 ,  C12N2710/16621 ,  C12N2710/16622 ,  C12N2710/16632 ,  C12N2710/16641 ,  C12N2710/16643 ,  C12N2710/16645 ,  C12N2710/16662 ,  C12N2710/16671

摘要： The present invention provides a recombinant herpes simplex virus (HSV), comprising (a) a mutation of the glycoprotein B (gB) at position 285 or 549, (b) a plurality of copies of one or more microRNA target sequences inserted into a locus of an HSV gene required for HSV replication, wherein said target sequence is the reverse complement of microRNA miR-124 and wherein said target sequence is present in the ICP4 gene, and (c) a transgene encoding a matrix metalloproteinase. The present invention also provides a method of killing a cancerous cell using a recombinant HSV according to the invention and a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a recombinant HSV according to the invention.

公开(公告)号：US20170266275A1

公开(公告)日：2017-09-21

申请号：US15310004

申请日：2015-05-08

申请人： Board of Supervisors of Louisiana State University and Agricultural and Mechanical College

发明人： Konstantin G. Kousoulas

IPC分类号： A61K39/245 ,  C12N7/00

CPC分类号： A61K39/245 ,  A61K39/12 ,  A61K2039/5254 ,  C12N7/00 ,  C12N2710/16622 ,  C12N2710/16634 ,  C12N2710/16662

摘要： The present invention provides vaccines for treating or preventing a herpes simplex virus infection and methods of using and making the vaccine. Further provided are recombinant herpes simplex virus genomes, recombinant viruses, and immunogenic compositions.