公开(公告)号：US20240174986A1

公开(公告)日：2024-05-30

申请号：US18284793

申请日：2022-03-28

申请人： Rational Vaccines, Inc.

发明人： Agustin FERNANDEZ ,  Edward GERSHBURG ,  Paul PREDKI

IPC分类号： C12N7/00 ,  A61K39/00 ,  A61K39/245 ,  A61P31/22 ,  C07K14/005

CPC分类号： C12N7/00 ,  A61K39/245 ,  A61P31/22 ,  C07K14/005 ,  A61K2039/522 ,  C12N2710/16621 ,  C12N2710/16622 ,  C12N2710/16634

摘要： Compositions and methods related to a mutant herpesvirus and a mutant ICP0 protein. Vaccine compositions comprising the mutant herpesvirus and/or mutant ICP0 protein. Methods of treatment using the mutant herpesvirus and/or mutant ICP0 protein.

公开(公告)号：US20230358746A1

公开(公告)日：2023-11-09

申请号：US18030154

申请日：2021-10-06

申请人： Rational Vaccines, Inc.

发明人： Agustin FERNANDEZ ,  Edward GERSHBURG ,  Paul PREDKI

IPC分类号： G01N33/569 ,  G01N33/58 ,  G01N21/64

CPC分类号： G01N33/56983 ,  G01N33/582 ,  G01N21/6428 ,  G01N2333/165 ,  G01N2469/20 ,  G01N2021/6439

摘要： The disclosure provides an assay for detecting if a subject is seropositive for SARS-CoV-2, or not, comprising incubating a biological sample from the subject with uninfected cells and SARS-CoV-2-infected cells, where the uninfected cells and the SARS-CoV-2-infected cells are distinguishable from each other, to form an admixture, and determining an amount of antibodies in the biological sample bound to the uninfected cells and to the SARS-CoV-2-infected cells, thereby determining whether the subject whose biological sample was tested is seropositive for SARS-CoV-2, or not.