公开(公告)号：US20230111803A1

公开(公告)日：2023-04-13

申请号：US17913707

申请日：2021-04-07

申请人： Albert Einstein College of Medicine

发明人： Betsy C. Herold

IPC分类号： A61K39/245 ,  A61P27/02

摘要： Methods of treating or preventing ocular disease caused by herpes simplex virus-1 infection are provided, and comprise administering to a subject an effective amount of a herpes simplex virus-2 (HSV-2) having a deletion of an HSV-2 glycoprotein D-encoding gene in the genome to treat or prevent ocular disease in the subject, wherein the HSV-2 is phenotypically complemented with an HSV-1 glycoprotein D by propagating the HSV-2 in a complementing cell expressing the HSV-1 glycoprotein D.

公开(公告)号：US11684670B2

公开(公告)日：2023-06-27

申请号：US17335548

申请日：2021-06-01

申请人： Albert Einstein College of Medicine

发明人： Betsy C. Herold ,  Clare Burn Aschner

IPC分类号： A61K39/245 ,  A61P31/22 ,  A61K9/00 ,  C12N7/00 ,  A61K39/00

CPC分类号： A61K39/245 ,  A61K9/0019 ,  A61P31/22 ,  C12N7/00 ,  A61K2039/54 ,  C12N2710/16621 ,  C12N2710/16622 ,  C12N2710/16634

摘要： Methods of vaccinating, immunizing and/or treating a subject against a herpes simplex virus infection or a disease caused by a herpes simplex virus infection comprise administering to the subject an effective amount of a HSV-2 single-cycle virus and an effective amount of a recombinant HSV-2 glycoprotein D, wherein the HSV-2 single-cycle virus comprises HSV-2 having a deletion of glycoprotein D-encoding gene in the genome and the HSV-2 is phenotypically complemented with an HSV-1 glycoprotein D on a lipid bilayer of the HSV-2.

公开(公告)号：US20240352094A1

公开(公告)日：2024-10-24

申请号：US18580318

申请日：2022-07-20

申请人： Albert Einstein College of Medicine

发明人： Jonathan R. Lai ,  Karen Tong ,  Betsy C. Herold ,  Aakash M. Mahant

IPC分类号： C07K16/08 ,  A61K39/00 ,  A61P31/22 ,  A61P37/04

CPC分类号： C07K16/087 ,  A61P31/22 ,  A61P37/04 ,  A61K2039/505

摘要： Provided herein are compositions and methods for the treatment of Herpes Simplex Virus infections.

公开(公告)号：US11382919B2

公开(公告)日：2022-07-12

申请号：US16765307

申请日：2018-11-27

申请人： ALBERT EINSTEIN COLLEGE OF MEDICINE

发明人： Betsy C. Herold ,  Steven C. Almo ,  Natalia Cheshenko ,  Jeffrey Bryan Bonanno

IPC分类号： A61K31/553 ,  A61P31/22 ,  A61K9/00

摘要： Methods and compositions are provided for inhibiting or treating a viral infection in a subject using cell-impermeable inhibitors of Akt, scramblase and/or a phosphatidylserine.