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公开(公告)号：US20240261139A1
公开(公告)日：2024-08-08
申请号：US18640036
申请日：2024-04-19
发明人： Anuj Chauhan , Keith G. Christopher
CPC分类号： A61F9/0017 , A61N1/0436 , A61N1/044 , A61N1/303
摘要： In one aspect, the disclosure relates to drug delivery devices for the ionophoretic delivery of a therapeutic agent(s) to the eye. In some aspects, the disclosed ionophoretic ocular delivery device is configured for delivery of a therapeutic agent to the anterior portion of the eye. In various aspects, the present disclosure provides methods for treatment of an ophthalmological disorder, disease, or clinical condition by delivering a therapeutic agent(s) to the eye using a disclosed ionophoretic ocular delivery device. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
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公开(公告)号：US20240157124A1
公开(公告)日：2024-05-16
申请号：US18509847
申请日：2023-11-15
申请人： Novocure GmbH
发明人： Richard Deslauriers
CPC分类号： A61N1/0496 , A61N1/044 , A61N1/0476 , A61N1/36002 , C08J3/075 , C08J2301/02 , C08J2333/02 , C08J2339/06
摘要： A conductive gel composition for use with a TTField-generating system is disclosed. Also disclosed are kits containing the gel composition and methods of producing and using the gel composition. The composition includes a semi-solid conductive gel for application to a patient's skin and for placement between the patient's skin and at least one transducer array that generates an alternating electric field having a frequency in a range of from about 50 kHz to about 500 kHz, wherein the conductive gel comprises a free salt present at a concentration in a range of from about 0.1 mM to about 1 M.
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公开(公告)号：US11964146B2
公开(公告)日：2024-04-23
申请号：US17885988
申请日：2022-08-11
申请人： Novocure GmbH
CPC分类号： A61N1/0476 , A61K41/0052 , A61N1/0408 , A61N1/044 , A61N1/0484 , A61N1/0492 , A61N1/321 , A61N1/40 , A61B2018/00059 , A61B2018/00636
摘要： Tumors in portions of a subject's body that have a longitudinal axis (e.g., the torso, head, and arm) can be treated with TTFields by affixing first and second sets of electrodes at respective positions that are longitudinally prior to and subsequent to a target region. An AC voltage with a frequency of 100-500 kHz is applied between these sets of electrodes. This imposes an AC electric field with field lines that run through the target region longitudinally. The field strength is at least 1 V/cm in at least a portion of the target region. In some embodiments, this approach is combined with the application of AC electric fields through the target region in a lateral direction (e.g., front to back and/or side to side) in order to apply AC electric fields with different orientations to the target region.
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公开(公告)号：US20190209830A1
公开(公告)日：2019-07-11
申请号：US16241018
申请日：2019-01-07
发明人： Nicholas Spring , Jacqueline Simon
CPC分类号： A61N1/0456 , A61H39/002 , A61N1/044 , A61N1/0492 , A61N1/36025 , A61N1/3603
摘要： A method of reducing or eliminating vertigo symptoms in an individual experiencing vertigo or an individual identified as being susceptible to vertigo is disclosed. The method includes positioning a non-invasive nerve stimulation device on the individual's wrist, wherein the electrodes of the non-invasive nerve stimulation device are in electrically conductive contact with skin at acupuncture point P6 of the wrist. The methods also include generating a stimulation signal and delivering the stimulation signal to the acupuncture point P6 of the wrist to prevent, reduce or eliminate one or more vertigo symptoms in the individual. The vertigo symptoms may include a feeling of spinning, tilting, swaying, or being unbalanced or pulled to one direction, vomiting, abnormal or jerking eye movements (nystagmus), headache, sweating, ringing in the ears, hearing loss, visual disturbances, weakness, difficulty speaking, a decreased level of consciousness, and difficulty walking.
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5.发明申请公开(公告)号：US20180272114A1
公开(公告)日：2018-09-27
申请号：US15933504
申请日：2018-03-23
发明人： Lei LIU , HongMei ZANG
CPC分类号： A61M37/0015 , A61M2037/0007 , A61M2037/0023 , A61M2037/0061 , A61M2205/3569 , A61M2205/3576 , A61M2205/50 , A61M2205/8206 , A61M2210/04 , A61N1/044 , A61N1/0476
摘要： An active molecule delivery system whereby active molecules can be released on demand and/or a variety of different active molecules can be delivered from the same system and/or different concentrations of active molecules can be delivered from the same system. The active delivery system includes a plurality of microcells, wherein the microcells are filled with a medium for delivering the active molecules. In some embodiments the medium includes active molecules dispersed in a first charged phase as well as a second phase that is oppositely charged or uncharged and immiscible with the first phase. Where the medium includes a charged first phase, the first phase can be moved adjacent to, or away from, the porous diffusion layer in order to control the rate of delivery.
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公开(公告)号：US09956403B2
公开(公告)日：2018-05-01
申请号：US14507483
申请日：2014-10-06
申请人： Activatek, Inc.
发明人： Jamal S. Yanaki
CPC分类号： A61N1/303 , A61K9/7023 , A61N1/044 , A61N1/0448 , A61N1/08 , A61N1/325
摘要： An active transdermal medicament patch includes a planar substrate with a therapeutic face releasably retainable against the skin of a patient. A return electrode and a medicament matrix susceptible to permeation by medicament are secured at separated locations on the therapeutic face and electrically conductively engage the skin. A detector monitors iontophoretic medicament migration into the skin. An integrator operating on the output of the detector produces a running cumulative total of the amount of medicament delivered during a plurality of temporally non-contiguous therapy subsessions. A circuit breaker terminates medicament migration, when the output of the integrator equals a predetermined medicament quantity. A timer active during medicament migration stimulates a driver to operate a light-emitting diode in a distinct delivery confirmation mode during each a sequence of non-overlapping predetermined therapy subsessions, respectively. A circuit board on the substrate in a compact, folded state bears interconnected electrical circuit components.
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公开(公告)号：US20180049856A1
公开(公告)日：2018-02-22
申请号：US15549860
申请日：2016-02-09
申请人： Dan Andrei Ionescu , Anil Kishen
发明人： Dan Andrei Ionescu , Anil Kishen
摘要： Various embodiments are described herein for a system and method for reducing bacteria of a tooth receiving root canal treatment, the tooth having a root canal, and the method includes deploying an intracanal electrode within the root canal; deploying an intraoral electrode in close proximity to the root canal and external to the tooth; and applying a potential difference between the electrodes to create an electric field therebetween to reduce the bacteria of the tooth.
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公开(公告)号：US20170252557A1
公开(公告)日：2017-09-07
申请号：US15500195
申请日：2015-07-16
申请人： L'OREAL
CPC分类号： A61N1/303 , A61B18/14 , A61B18/18 , A61B2018/00083 , A61B2018/0047 , A61B2018/00714 , A61B2018/00791 , A61B2018/1467 , A61M35/003 , A61N1/044 , A61N1/325
摘要： The invention relates to an end piece intended for equipping a device for cosmetic treatment of keratin materials with an electric current, the end piece comprising an application member (6) comprising an electrode (1) and a counter electrode (2), said electrode (1) and counter electrode (2) being separated from one another by an electrically insulating zone (3).
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公开(公告)号：US20170246445A1
公开(公告)日：2017-08-31
申请号：US15500203
申请日：2015-07-16
申请人： L'OREAL
CPC分类号： A61N1/044 , A61M35/00 , A61M37/00 , A61M2210/0606 , A61N1/0424 , A61N1/0476 , A61N1/0484 , A61N1/0492 , A61N1/205 , A61N1/303 , A61N1/325 , A61N1/327 , A61N1/328
摘要： One subject of the invention is an article for cosmetic treatment of a body area with an electric current, comprising a support (50) comprising an electrode (1) and a counter electrode (2), said electrode and counter electrode being separated from one another by a space comprising an electrically insulating zone (3) made of a polymeric material.
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公开(公告)号：US20170232249A1
公开(公告)日：2017-08-17
申请号：US15508942
申请日：2015-07-27
申请人： FASTMEDITALIA S.R.L.
发明人： Marco PINNA
IPC分类号： A61N1/04
CPC分类号： A61N1/0492 , A61N1/0428 , A61N1/0436 , A61N1/044 , A61N1/0448 , A61N1/0456 , A61N1/30
摘要： Provided is a patch able to produce micro-current to be applied on human skin including a support for electrodes spaced from each other and apt to create voltages typical of galvanic piles, connection means between the electrodes, an adhesive layer applied on one side of the support and apt to adhere to the skin and a protection liner applied on the adhesive layer, the support being a membrane permeable to the moisture inside the electrodes, and the connection means being defined by a material that is avid of moisture, such as silica impregnating the membrane.
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