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公开(公告)号：US20240316340A1
公开(公告)日：2024-09-26
申请号：US18731865
申请日：2024-06-03
申请人： Novocure GmbH
发明人： Richard Deslauriers
CPC分类号： A61N1/0496 , A61N1/044 , A61N1/0476 , A61N1/36002 , C08J3/075 , C08J2301/02 , C08J2333/02 , C08J2339/06
摘要： A conductive gel composition for use with a TTField-generating system is disclosed. Also disclosed are kits containing the gel composition and methods of producing and using the gel composition. The composition includes a semi-solid conductive gel for application to a patient's skin and for placement between the patient's skin and at least one transducer array that generates an alternating electric field having a frequency in a range of from about 50 kHz to about 500 kHz, wherein the conductive gel comprises a free salt present at a concentration in a range of from about 0.1 mM to about 1 M.
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公开(公告)号：US12083332B2
公开(公告)日：2024-09-10
申请号：US17490120
申请日：2021-09-30
申请人： Novocure GmbH
CPC分类号： A61N1/0476 , A61N1/36002 , A61N1/3603 , A61N1/40
摘要： Apparatus and methods for imposing electric fields through a target region in a body of a patient are described. Generally, the apparatus includes at least one transducer array and a connector electrically connected to the at least one transducer array. The connector has at least one indicator electrical connector configured to provide feedback related to a status of the connector.
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公开(公告)号：US20240216679A1
公开(公告)日：2024-07-04
申请号：US18392075
申请日：2023-12-21
申请人： Novocure GmbH
CPC分类号： A61N1/36002 , A61N1/0484 , G16H20/40
摘要： Increasing the strength of tumor treating Fields (TTFields) or other alternating electric field treatments will typically increase the efficacy of treatment. This application discloses methods of determining where to position a plurality of electrode elements on a subject's body so that higher currents (which yield higher-strength fields) can be driven through the electrode elements during a treatment session without overheating the electrode elements. The position selection is based on the fact that some regions on the surface of a given subject's body are better at carrying heat away from the electrode elements, as compared to other regions that may only be a short distance away. And the methods disclosed herein rely on positioning the electrode elements at the regions that are better at carrying heat away from the electrode elements.
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公开(公告)号：US20240198099A1
公开(公告)日：2024-06-20
申请号：US18004492
申请日：2021-07-09
申请人： Duke University
发明人： Xiling SHEN , Aliesha O'RAW , James MORIZIO , Ashlesha DESHMUKH , Ayelet EREZ , Saar EZAGOURI
CPC分类号： A61N1/36002 , A61N1/36034 , A61N5/0622
摘要： A method for treating cachexia in a subject in need thereof includes stimulating the parasympathetic nervous system of the subject thereby treating cachexia in the subject. Stimulating the parasympathetic nervous system can increase expression of urea cycle enzymes in the liver of the subject. Parasympathetic nervous system stimulation can comprise stimulating the vagus nerve, for example, the cervical vagus nerve or the hepatic branch of the vagus nerve. Pulses can be delivered at a frequency ranging from 1 Hz to 10 Hz or at a frequency of about 5 KHz.
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5.发明公开公开(公告)号：US20240173546A1
公开(公告)日：2024-05-30
申请号：US18551453
申请日：2022-04-04
申请人： Dignity Health
发明人： Benjamin Hendricks
CPC分类号： A61N1/36002 , A61N1/025 , A61N1/0476 , A61N1/36031 , A61N1/36034
摘要： A modular electrode system for therapeutic application of an electric field to a tissue is described. The modular electrode system includes a flexible scaffold that conforms to a variable convex or concave surface such as a resected tissue cavity or other target tissue area and includes one or more surface electrodes in addition to one or more depth electrodes. The modular electrode system includes a control system that communicates with the plurality of electrodes of the flexible scaffold to deliver a stimulating voltage and receive measured voltage values for real-time optimization of the electric field generated within the tissue.
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公开(公告)号：US20240165406A1
公开(公告)日：2024-05-23
申请号：US18511562
申请日：2023-11-16
申请人： Novocure GmbH
发明人： Richard Deslauriers
CPC分类号： A61N1/36002 , A61N1/0492 , A61N1/36034
摘要： A system for generating a TTField is herein described. The system comprises a generator configured to generate an electrical signal; a first lead coupled to the generator and a first conductive pad and configured to carry the electrical signal; the first conductive pad having a first electrode element electrically coupled to a first conductive gel element to supply electrical current to the first conductive gel element; a second lead coupled to the generator and a second conductive pad and configured to carry the electrical signal; and the second conductive pad having the second electrode element electrically coupled to a second conductive gel element to supply electrical current to the second conductive gel element, wherein the first conductive gel element and the second conductive gel element are each configured to be in contact with a patient's skin and each supporting a shaping member adjacent to one or more air channel.
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公开(公告)号：US11883655B2
公开(公告)日：2024-01-30
申请号：US17182436
申请日：2021-02-23
CPC分类号： A61N1/36002 , A61N1/0509 , A61N1/08 , A61N1/36007 , A61N1/40
摘要： Embodiments herein relate to medical devices and methods for using the same to treat cancerous tumors within a bodily tissue. A medical device system herein can include an electric field generating circuit configured to generate one or more electric fields, and control circuitry. The system can include one or more electrodes disposed on a first stimulation lead to deliver the electric fields to a site of a cancerous tumor within a patient and one or more electrodes disposed on a second stimulation lead to deliver the electric fields to the site of a cancerous tumor within a patient. The first and second stimulation leads can be configured to be implanted on or about a duodenum. The electric field generating circuit can generate electric fields at frequencies selected from a range of between 10 kHz to 1 MHz. Other embodiments are also included herein.
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8.发明授权公开(公告)号：US11850423B2
公开(公告)日：2023-12-26
申请号：US17624758
申请日：2019-09-04
发明人： Yongdong Jin , Guohua Qi , Bo Wang
IPC分类号： A61N1/36
CPC分类号： A61N1/36002
摘要： The invention discloses an electrochemical device for treating cancer, characterized by using an acupuncture needle as a working electrode to produce hydrogen in a tumor tissue, thereby destroying the tumor tissue through the produced hydrogen gas. The device of the invention has low cost and simple operation, can realize minimally invasive treatment, and is green and environmentally friendly.
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9.发明授权公开(公告)号：US11833362B2
公开(公告)日：2023-12-05
申请号：US17106531
申请日：2020-11-30
申请人： NOVOCURE GMBH
CPC分类号： A61N1/406 , A61N1/327 , A61N1/36002 , G06T7/0012 , G06T2207/30096
摘要： Disclosed are methods of altering the electric impedance to an alternating electric field in a target site of a subject, comprising introducing a nanoparticle to a target site in the subject; and applying an alternating electric field to the target site of the subject, wherein the electric impedance in the target site of the subject to the alternating current is altered. Disclosed are methods for improving transport of a nanoparticle across a cell membrane of a cell, the method comprising applying an alternating electric field to the cell for a period of time, wherein application of the alternating electric field increases permeability of the cell membrane; and introducing the nanoparticle to the cell, wherein the increased permeability of the cell membrane enables the nanoparticle to cross the cell membrane. Disclosed are methods of imaging a cancer cell, the method comprising applying a first alternating electric field at a first frequency to the cancer cell for a first period of time, wherein application of the first alternating electric field at the first frequency to the cancer cell for the first period of time increases permeability of cell membranes of the cancer cell; introducing a nanoparticle to the cancer cell, wherein the increased permeability of the cell membranes enables the nanoparticle to cross the cancer cell membrane; and imaging the cancer cell.
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公开(公告)号：US20230310849A1
公开(公告)日：2023-10-05
申请号：US18129510
申请日：2023-03-31
申请人： Novocure GmbH
IPC分类号： A61N1/36
CPC分类号： A61N1/36002
摘要： Alternating electric fields (e.g., tumor treating fields, a.k.a. TTFields) may be applied to a target region in a subject's body via sheets of graphite that are implanted in the subject's body. One or more ports configured for affixation to the subject's body include or connect to one or more mating electrical connectors. Electrical conductors are positioned to route electrical signals between the electrical connector(s) and the sheets of graphite. The alternating electric fields are applied to the target region by applying (via the ports) an alternating voltage between two sheets of graphite that are positioned on opposite sides of the target region.
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