公开(公告)号：US20240198099A1

公开(公告)日：2024-06-20

申请号：US18004492

申请日：2021-07-09

申请人： Duke University

发明人： Xiling SHEN ,  Aliesha O'RAW ,  James MORIZIO ,  Ashlesha DESHMUKH ,  Ayelet EREZ ,  Saar EZAGOURI

IPC分类号： A61N1/36 ,  A61N5/06

CPC分类号： A61N1/36002 ,  A61N1/36034 ,  A61N5/0622

摘要： A method for treating cachexia in a subject in need thereof includes stimulating the parasympathetic nervous system of the subject thereby treating cachexia in the subject. Stimulating the parasympathetic nervous system can increase expression of urea cycle enzymes in the liver of the subject. Parasympathetic nervous system stimulation can comprise stimulating the vagus nerve, for example, the cervical vagus nerve or the hepatic branch of the vagus nerve. Pulses can be delivered at a frequency ranging from 1 Hz to 10 Hz or at a frequency of about 5 KHz.