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公开(公告)号：US11965854B2
公开(公告)日：2024-04-23
申请号：US17509485
申请日：2021-10-25
发明人： Thomas Kjaer
IPC分类号： G01N27/327 , C12Q1/00 , G01N33/70
CPC分类号： G01N27/3274 , C12Q1/005 , G01N33/70 , G01N2333/90683 , G01N2333/986
摘要： A method of calibrating a device for measuring the concentration of creatinine using one or more calibration solutions, the method comprising: receiving concentrations at an initial time of creatine, Cr, and/or creatinine, Crn, of the one or more calibration solutions; receiving outputs of the measuring device at the end time; calculating the concentration of Cr and/or Crn in the calibration solutions at an end time using a temperature model, wherein the temperature model indicates changes in temperature of the calibration solutions from the initial time to the end time; and determining a relationship between the outputs of the measuring device and the calculated concentrations of Cr and/or Crn.
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公开(公告)号：US20170315139A1
公开(公告)日：2017-11-02
申请号：US15533692
申请日：2015-12-14
IPC分类号： G01N33/70 , C12Q1/00 , G01N27/327
CPC分类号： G01N33/70 , C12Q1/005 , C12Y105/03001 , C12Y305/0201 , G01N27/3273 , G01N27/3274 , G01N2333/90683 , G01N2333/986
摘要： A method of calibrating a device for measuring the concentration of creatinine using one or more calibration solutions, the method comprising: receiving concentrations at an initial time of creatine, Cr, and/or creatinine, Crn, of the one or more calibration solutions; receiving outputs of the measuring device at the end time; calculating the concentration of Cr and/or Crn in the calibration solutions at an end time using a temperature model, wherein the temperature model indicates an estimation of the temperature of the calibration solutions from the initial time to the end time, and wherein the temperature model includes a variable parameter; and determining a relationship between the outputs of the measuring device and the calculated concentrations of Cr and/or Crn.
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公开(公告)号：US20240230578A1
公开(公告)日：2024-07-11
申请号：US18609422
申请日：2024-03-19
发明人： Thomas KJAER
IPC分类号： G01N27/327 , C12Q1/00 , G01N33/70
CPC分类号： G01N27/3274 , C12Q1/005 , G01N33/70 , G01N2333/90683 , G01N2333/986
摘要： A method of calibrating a device for measuring the concentration of creatinine using one or more calibration solutions, the method comprising: receiving concentrations at an initial time of creatine, Cr, and/or creatinine, Crn, of the one or more calibration solutions; receiving outputs of the measuring device at the end time; calculating the concentration of Cr and/or Crn in the calibration solutions at an end time using a temperature model, wherein the temperature model indicates changes in temperature of the calibration solutions from the initial time to the end time; and determining a relationship between the outputs of the measuring device and the calculated concentrations of Cr and/or Crn.
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公开(公告)号：US20140262776A1
公开(公告)日：2014-09-18
申请号：US14206174
申请日：2014-03-12
发明人： Glenn Martin , G. Bruce Collier , Dan Wang
IPC分类号： G01N27/327
CPC分类号： G01N27/3271 , C12Q1/004 , G01N27/3277 , G01N2333/90206 , G01N2333/90683
摘要： This invention relates to mutagenized redox oxidase enzymes used to design enzyme electrodes with improved interference characteristics in the presence of mediator and oxygen in the assay. This recombinant modified enzyme has enhanced capability to transfer electrons to redox mediator instead of its natural electron acceptors such as O2, NAD, NADP, etc., which will improve the assay performance with less interference and higher sensitivity.
摘要翻译： 本发明涉及用于在测定中存在介质和氧的情况下具有改进的干扰特性的酶电极的诱变氧化还原氧化酶。 这种重组修饰的酶具有增强将电子转移到氧化还原介体而不是其天然电子受体如O 2，NAD，NADP等的能力，这将以更少的干扰和更高的灵敏度提高测定性能。
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公开(公告)号：US11874285B2
公开(公告)日：2024-01-16
申请号：US15533692
申请日：2015-12-14
IPC分类号： G01N33/70 , G01N27/327 , C12Q1/00
CPC分类号： G01N33/70 , C12Q1/005 , C12Y105/03001 , C12Y305/0201 , G01N27/3274 , G01N27/3273 , G01N2333/90683 , G01N2333/986
摘要： A method of calibrating a device for measuring the concentration of creatinine using one or more calibration solutions, the method comprising: receiving concentrations at an initial time of creatine, Cr, and/or creatinine, Crn, of the one or more calibration solutions; receiving outputs of the measuring device at the end time; calculating the concentration of Cr and/or Crn in the calibration solutions at an end time using a temperature model, wherein the temperature model indicates an estimation of the temperature of the calibration solutions from the initial time to the end time, and wherein the temperature model includes a variable parameter; and determining a relationship between the outputs of the measuring device and the calculated concentrations of Cr and/or Crn.
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6.发明申请公开(公告)号：US20170363568A1
公开(公告)日：2017-12-21
申请号：US15536910
申请日：2015-12-14
IPC分类号： G01N27/327 , C12Q1/00
CPC分类号： G01N27/3274 , C12Q1/002 , C12Q1/005 , C12Y105/03001 , C12Y305/0201 , G01N33/70 , G01N2333/90683 , G01N2333/986
摘要： A method of calibrating a device for measuring the concentration of creatinine in a sample including one or more enzyme modulators, the method comprising: determining sensitivities of the device for each of two or more calibration solutions, wherein each calibration solution has a different amount of enzyme modulator; determining a degree of modulation for each of the two or more calibration solutions; determining a degree of modulation for a sample to be measured; and calculating the sensitivity of the device for the sample, wherein said calculating comprises modifying the sensitivity of one of the two or more calibration solutions by a function comprising the determined degrees of modulation.
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7.发明申请TEST STRIP USING FORMALDEHYDE OR PEROXIDE, FROM AMONG SARCOSINE METABOLITES, FOR DIAGNOSING PROSTATE CANCER, AND METHOD FOR DIAGNOSING PROSTATE CANCER USING SAME 审中-公开使用甲硫菊酯或过氧化物，来自焦磷酸酯代谢物，用于诊断前列腺癌的测试条以及使用其诊断前列腺癌的方法公开(公告)号：US20160222432A1
公开(公告)日：2016-08-04
申请号：US15022102
申请日：2014-09-30
申请人： CSQUARE CO., LTD
发明人： Youngsoo LEE
CPC分类号： C12Q1/26 , C12Q1/28 , G01N33/558 , G01N33/57434 , G01N2333/90683 , G01N2333/908
摘要： The present invention relates to a test strip using formaldehyde or peroxide, which are sarcosine metabolites, for diagnosing prostate cancer, and a method for diagnosing prostate cancer by means of the test strip, the present invention allowing a simpler and more rapid diagnosis of prostate cancer than the conventional methods, such as using a spectrophotometer, and with respect to qualifying and quantifying sarcosine in urine, the test strip is reacted in a test urine sample, as with a conventional urinalysis test strip, so as to allow the color change to be visually checked, thereby allowing prostate cancer to be diagnosed without professional personnel and expensive equipment.
摘要翻译： 本发明涉及一种使用甲醛或过氧化物（其为肌氨酸代谢物），用于诊断前列腺癌的测试条和通过测试条诊断前列腺癌的方法，本发明允许更容易和更快速地诊断前列腺癌 比如使用分光光度计的常规方法，并且关于尿液中的肌氨酸的合格和定量，测试条在测试尿样中与常规尿分析试纸一样反应，以使颜色变化 目视检查，从而允许诊断前列腺癌，而无需专业人员和昂贵的设备。
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公开(公告)号：US20180202963A1
公开(公告)日：2018-07-19
申请号：US15742121
申请日：2016-06-20
IPC分类号： G01N27/327 , C12Q1/00 , G01N33/70
CPC分类号： G01N27/3274 , C12Q1/001 , C12Q1/005 , C12Y105/03001 , C12Y305/0201 , C12Y305/03003 , G01N33/70 , G01N2333/90683 , G01N2333/978 , G01N2333/986 , G01N2496/00
摘要： A method of calibrating a device for measuring the concentration of creatinine in a sample including one or more enzyme modulators, the device comprising an enzyme layer, the method comprising: determining sensitivities of the device for each of one or more calibration solutions; determining a degree of modulation for the sample to be measured, determining a degree of modulation for each calibration solution; wherein said determining of each of the degrees of modulation comprises estimating the concentration of an enzyme modulator in the enzyme layer of the device; and calculating the sensitivity of the device for the sample, wherein the said calculating comprises adjusting the sensitivity of the device for each calibration solution by a factor comprising the determined degrees of modulation of the sample and the calibration solution.
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公开(公告)号：US20170284954A1
公开(公告)日：2017-10-05
申请号：US15475719
申请日：2017-03-31
IPC分类号： G01N27/327 , C12Q1/00
CPC分类号： G01N27/3272 , C12Q1/004 , C12Q1/005 , C12Y105/03001 , C12Y105/08003 , C12Y305/04021 , G01N27/3273 , G01N2333/9065 , G01N2333/90683 , G01N2333/978
摘要： A system for the electrochemical detection of creatinine levels includes a test strip including an electrode and a counter electrode, the electrode and counter electrode located proximate to a sample reception area; and a coating on one of the electrode and counter electrode, the coating including a reagent coating for creatinine.
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公开(公告)号：US20170199146A1
公开(公告)日：2017-07-13
申请号：US14994301
申请日：2016-01-13
发明人： SIDDHESWAR MAIKAP , KANISHK SINGH
IPC分类号： G01N27/403 , G01N27/416 , G01N33/487 , G01N27/30
CPC分类号： G01N27/403 , G01N27/227 , G01N27/301 , G01N27/4035 , G01N27/4161 , G01N33/48707 , G01N2333/90683
摘要： The present invention relates to a prostate screening module and the method for operating the same. It uses nanometer-grade nickel oxide as the screening film. By contacting nickel oxide with hydrogen peroxide having various concentrations, the surface potential of nickel oxide will be changed and resulting in voltage shift, which can be used to judge the concentration of hydrogen peroxide. The sample for screening is urine or blood serum. After the sarcosine in urine or blood serum is oxidized and forming hydrogen peroxide, the content of sarcosine in the sample can be deduced by means of the reaction between hydrogen peroxide and nickel oxide. Accordingly, the possibility of prostate cancer can be evaluated.
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