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1.发明申请公开(公告)号：US20140106387A1
公开(公告)日：2014-04-17
申请号：US14135015
申请日：2013-12-19
Applicant: MD BIOALPHA CO., LTD.
Inventor： Myung-Gyu PARK , Sang-Ku YOO , In Geun JO , Taehwan KWAK
IPC: C12Q1/26
CPC classification number: C12Q1/26 , A61K31/12 , A61K31/343 , A61K38/44 , C12Y106/05002
Abstract: Provided is a method capable of effectively treating various diseases associated with energy excess, such as obesity, diabetes, metabolic syndromes, degenerative diseases and mitochondrial dysfunction-related diseases, via elevation of an NAD(P)+/NAD(P)H ratio by increasing an NAD(P)+ concentration in vivo or in vitro through use of NAD(P)H as a substrate or coenzyme by oxidoreductase such as NAD(P)H:quinone oxidoreductase (NQO1), a method of screening a drug for the same and a therapeutic drug.
Abstract translation: 本发明提供能够通过NAD（P）+ / NAD（P）H比例升高来有效治疗与能量过量相关的各种疾病，如肥胖，糖尿病，代谢综合征，退行性疾病和线粒体功能障碍相关疾病的方法。 通过使用NAD（P）H作为底物或通过氧化还原酶如NAD（P）H：醌氧化还原酶（NQO1）的氧化还原酶的辅酶，在体内或体外增加NAD（P）+浓度， 相同和治疗药物。
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2.发明公开公开(公告)号：US20240247297A1
公开(公告)日：2024-07-25
申请号：US18597704
申请日：2024-03-06
Applicant: Abbott Diabetes Care Inc.
Inventor： Tianmei OUYANG , Benjamin J. FELDMAN
IPC: C12Q1/00 , A61B5/1486 , C12N11/082 , C12Q1/26 , G01N27/27 , G01N27/327 , G01N33/573 , G01N33/66
CPC classification number: C12Q1/001 , A61B5/14865 , C12N11/082 , C12Q1/004 , C12Q1/005 , C12Q1/006 , C12Q1/26 , G01N27/3275 , G01N33/5735 , G01N33/66 , C12Y106/05002 , G01N27/27
Abstract: NADP-dependent oxidoreductase compositions, and electrodes, sensors and systems that include the same. Analyte sensors include an electrode having a sensing layer disposed thereon, the sensing layer comprising a polymer and an enzyme composition distributed therein. The enzyme composition includes nicotinamide adenine dinucleotide phosphate (NAD(P)+) or derivative thereof; an NAD(P)+-dependent dehydrogenase; an NAD(P)H oxidoreductase; and an electron transfer agent comprising a transition metal complex.
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公开(公告)号：US09540702B2
公开(公告)日：2017-01-10
申请号：US13400209
申请日：2012-02-20
Applicant: Wolfgang Roedel , Carina Horn , Nelli Steinke , Nadine Bucci , Thomas Meier , Rainer Schmuck , Rolf Nagel , Dieter Heindl
Inventor： Wolfgang Roedel , Carina Horn , Nelli Steinke , Nadine Bucci , Thomas Meier , Rainer Schmuck , Rolf Nagel , Dieter Heindl
IPC: C12N9/04
CPC classification number: C12N9/96 , C12N9/0006 , C12N9/0036 , C12Q1/26 , C12Q1/32 , C12Y101/01001 , C12Y101/01002 , C12Y101/01047 , C12Y101/01049 , C12Y106/05002 , C12Y106/99
Abstract: Methods for stabilizing an enzyme by storing the enzyme in the presence of a stabilized coenzyme are disclosed. In addition, an enzyme stabilized with a stabilized coenzyme as well as the use thereof in test elements for detecting analytes are also disclosed. Other aspects include unique compositions, methods, techniques, systems and devices involving enzyme stabilization.
Abstract translation: 公开了通过在稳定的辅酶的存在下储存酶来稳定酶的方法。 此外，还公开了用稳定的辅酶稳定的酶以及其用于检测分析物的测试元件中的用途。 其他方面包括独特的组合物，方法，技术，涉及酶稳定化的系统和装置。
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4.发明授权公开(公告)号：US12064243B2
公开(公告)日：2024-08-20
申请号：US16747720
申请日：2020-01-21
Applicant: Nova Biomedical Corporation
Inventor： Jianhong Pei , Joseph Bedard , Aaron Tram , Samantha Mosley , Chung Chang Young
IPC: A61B5/1486 , C12N9/02 , G01N27/327
CPC classification number: A61B5/1486 , C12N9/0008 , G01N27/3272 , C12Y102/01059 , C12Y106/05002
Abstract: A disposable biosensor that includes a sensing surface having at least a working electrode portion and a reference electrode portion, a first reagent disposed on the working electrode portion containing a NAD(P)-dependent dehydrogenase, NAD(P)+, diaphorase, and an oxidized form of a redox mediator forming a working electrode, and a reference electrode material disposed on the reference electrode portion forming a reference electrode.
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公开(公告)号：US20170073661A1
公开(公告)日：2017-03-16
申请号：US15363038
申请日：2016-11-29
Applicant: Roche Diabetes Care, Inc.
Inventor： Wolfgang Roedel , Carina Horn , Nelli Steinke , Nadine Bucci , Thomas Meier , Rainer Schmuck , Rolf Nagel , Dieter Heindl
CPC classification number: C12N9/96 , C12N9/0006 , C12N9/0036 , C12Q1/26 , C12Q1/32 , C12Y101/01001 , C12Y101/01002 , C12Y101/01047 , C12Y101/01049 , C12Y106/05002 , C12Y106/99
Abstract: Methods are provided for stabilizing an enzyme by storing the enzyme in the presence of a stabilized coenzyme. In addition, enzymes are provided that are stabilized with a stabilized coenzyme, as well as the use thereof in test elements for detecting analytes. Other aspects include unique compositions, methods, techniques, systems and devices involving enzyme stabilization.
Abstract translation: 提供了通过在稳定的辅酶的存在下储存酶来稳定酶的方法。 此外，提供了用稳定化的辅酶稳定的酶以及其用于检测分析物的测试元件中的用途。 其他方面包括独特的组合物，方法，技术，涉及酶稳定化的系统和装置。
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Patent Agency Ranking
公开(公告)号：US20170291918A1
公开(公告)日：2017-10-12
申请号：US15480881
申请日：2017-04-06
Applicant: SYSMEX CORPORATION
Inventor： Ryo TAKAHASHI
CPC classification number: C07K1/18 , C07K7/08 , C07K14/00 , C07K2319/20 , C07K2319/50 , C07K2319/61 , C12N9/0036 , C12N9/0069 , C12P21/02 , C12Y106/05002 , C12Y113/12007
Abstract: Disclosed is a method for purifying a protein, comprising steps of: preparing a sample containing a fusion protein containing an amino acid sequence of a peptide tag and an amino acid sequence of a target protein; and separating contaminant proteins contained with the fusion protein in the sample and the fusion protein in the sample, wherein the peptide tag contains 12 or more acidic amino acid residues.
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公开(公告)号：US09303251B2
公开(公告)日：2016-04-05
申请号：US14227747
申请日：2014-03-27
Applicant: SYSMEX CORPORATION
Inventor： Takahiko Bando , Mutsumi Sugai
IPC: C12N15/09 , C12N15/866 , C12N9/74 , C07K14/745 , C12P21/02 , C12N9/02 , C12N9/88 , C12N15/86 , C12N9/64
CPC classification number: C12N9/6429 , A01K2207/05 , A01K2227/706 , A01K2267/01 , C07K14/745 , C12N9/0036 , C12N9/6432 , C12N9/6437 , C12N9/644 , C12N9/6464 , C12N9/88 , C12N15/86 , C12N2710/14143 , C12P21/02 , C12Y106/05002 , C12Y401/0109 , Y02P20/52
Abstract: The present invention provides a recombinant baculovirus. The baculovirus has a genome into which a gene encoding γ-glutamyl carboxylase (GGCX) and a gene encoding DT-diaphorase (NQO1) are incorporated.The present invention further provides a method for producing a recombinant vitamin K-dependent protein by using the recombinant baculovirus.
Abstract translation: 本发明提供重组杆状病毒。 杆状病毒具有编码γ-谷氨酰羧化酶（GGCX）的基因和编码DT-心肌黄酶（NQO1）的基因的基因组。 本发明还提供了使用重组杆状病毒生产重组维生素K依赖性蛋白的方法。
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公开(公告)号：US20140295496A1
公开(公告)日：2014-10-02
申请号：US14227747
申请日：2014-03-27
Applicant: SYSMEX CORPORATION
Inventor： Takahiko BANDO , Mutsumi SUGAI
IPC: C07K14/745 , C12N9/64 , C12N9/74
CPC classification number: C12N9/6429 , A01K2207/05 , A01K2227/706 , A01K2267/01 , C07K14/745 , C12N9/0036 , C12N9/6432 , C12N9/6437 , C12N9/644 , C12N9/6464 , C12N9/88 , C12N15/86 , C12N2710/14143 , C12P21/02 , C12Y106/05002 , C12Y401/0109 , Y02P20/52
Abstract: The present invention provides a recombinant baculovirus. The baculovirus has a genome into which a gene encoding γ-glutamyl carboxylase (GGCX) and a gene encoding DT-diaphorase (NQO1) are incorporated.The present invention further provides a method for producing a recombinant vitamin K-dependent protein by using the recombinant baculovirus.
Abstract translation: 本发明提供重组杆状病毒。 杆状病毒具有编码γ-谷氨酰羧化酶（GGCX）的基因和编码DT-心肌黄酶（NQO1）的基因的基因组。 本发明还提供了使用重组杆状病毒生产重组维生素K依赖性蛋白的方法。
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公开(公告)号：US20120276565A1
公开(公告)日：2012-11-01
申请号：US13400209
申请日：2012-02-20
Applicant: Wolfgang Roedel , Carina Horn , Nelli Steinke , Nadine Bucci , Thomas Meier , Rainer Schmuck , Rolf Nagel , Dieter Heindl
Inventor： Wolfgang Roedel , Carina Horn , Nelli Steinke , Nadine Bucci , Thomas Meier , Rainer Schmuck , Rolf Nagel , Dieter Heindl
CPC classification number: C12N9/96 , C12N9/0006 , C12N9/0036 , C12Q1/26 , C12Q1/32 , C12Y101/01001 , C12Y101/01002 , C12Y101/01047 , C12Y101/01049 , C12Y106/05002 , C12Y106/99
Abstract: Methods for stabilizing an enzyme by storing the enzyme in the presence of a stabilized coenzyme are disclosed. In addition, an enzyme stabilized with a stabilized coenzyme as well as the use thereof in test elements for detecting analytes are also disclosed. Other aspects include unique compositions, methods, techniques, systems and devices involving enzyme stabilization.
Abstract translation: 公开了通过在稳定的辅酶的存在下储存酶来稳定酶的方法。 此外，还公开了用稳定的辅酶稳定的酶以及其用于检测分析物的测试元件中的用途。 其他方面包括独特的组合物，方法，技术，涉及酶稳定化的系统和装置。
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10.发明申请公开(公告)号：US20090215145A1
公开(公告)日：2009-08-27
申请号：US12162293
申请日：2007-02-15
Applicant: Myung-Gyu Park , Sang-Ku Yoo , In Geun Jo , Taehwan Kwak
Inventor： Myung-Gyu Park , Sang-Ku Yoo , In Geun Jo , Taehwan Kwak
IPC: C12N9/06 , C12N5/02 , A61K38/44 , A61K31/343 , A61K31/352 , C12Q1/26
CPC classification number: C12Q1/26 , A61K31/12 , A61K31/343 , A61K38/44 , C12Y106/05002
Abstract: Provided is a method capable of effectively treating various diseases associated with energy excess, such as obesity, diabetes, metabolic syndromes, degenerative diseases and mitochondrial dysfunction-related diseases, via elevation of an NAD(P)+/NAD(P)H ratio by increasing an NAD(P)+ concentration in vivo or in vitro through use of NAD(P)H as a substrate or coenzyme by oxidoreductase such as NAD(P)H:quinone oxidoreductase (NQO1), a method of screening a drug for the same and a therapeutic drug.
Abstract translation: 本发明提供能够通过NAD（P）+ / NAD（P）H比例升高来有效治疗与能量过量相关的各种疾病，如肥胖，糖尿病，代谢综合征，退行性疾病和线粒体功能障碍相关疾病的方法。 通过使用NAD（P）H作为底物或通过氧化还原酶如NAD（P）H：醌氧化还原酶（NQO1）的氧化还原酶的辅酶，在体内或体外增加NAD（P）+浓度， 相同和治疗药物。
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