公开(公告)号：US20230211342A1

公开(公告)日：2023-07-06

申请号：US18079860

申请日：2022-12-12

申请人： BioFluidica, Inc.

发明人： Rolf Muller ,  Mateusz Hupert

IPC分类号： B01L3/00 ,  B01L3/02

CPC分类号： B01L3/502753 ,  B01L3/021 ,  B01L3/502715 ,  B01L2200/027 ,  B01L2200/0647 ,  B01L2200/12 ,  B01L2400/0487 ,  B01L2300/0816 ,  B01L2300/12 ,  B01L2400/086

摘要： The presently disclosed subject matter provides dual-depth thermoplastic microfluidic devices, related kits, microfluidic systems comprising the dual-depth thermoplastic microfluidic device, methods of isolating nucleic acid analytes from a liquid sample, and methods of isolating extracellular vesicles from a liquid sample.

公开(公告)号：US20200023351A1

公开(公告)日：2020-01-23

申请号：US16577031

申请日：2019-09-20

申请人： BioFluidica, Inc.

发明人： Rolf Muller ,  Scott Beach ,  Judy Muller-Cohn

IPC分类号： B01L3/02 ,  G01N35/10 ,  B01L3/00

摘要： The presently disclosed subject matter provides a fluid-tight flow system; a method of isolating biomarker cells from a liquid sample; a method of extracting cfDNA, ctDNA, or exosomes from plasma; a method of extracting cfDNA, ctDNA, or exosomes from blood; a method of capturing DNA or RNA released from biomarker cells; a method of amplifying a nucleotide sequence; a method of sequencing a nucleotide sequence; a method of detecting a chromosomal abnormality; and a method of analyzing a protein.

公开(公告)号：US20230384337A1

公开(公告)日：2023-11-30

申请号：US18226733

申请日：2023-07-26

申请人： BioFluidica, Inc.

发明人： Rolf Muller ,  Judy Muller-Cohn ,  Philip D. Buchanan ,  Jiri Sonek ,  Kulvinder Kaur ,  Jennifer Barber-Singh ,  Paul Diaz

IPC分类号： G01N35/10 ,  G01N33/50

CPC分类号： G01N35/1065 ,  G01N33/5005

摘要： The presently disclosed subject matter provides methods of isolating fetal cells from a sample from a pregnant subject, methods of isolating multinucleated fetal giant cells from a sample from a pregnant subject, and related compositions and methods.

公开(公告)号：US20240351034A1

公开(公告)日：2024-10-24

申请号：US18542574

申请日：2023-12-15

申请人： BioFluidica, Inc.

发明人： Rolf Muller ,  Mateusz Hupert

IPC分类号： B01L3/00 ,  B01L3/02

CPC分类号： B01L3/502753 ,  B01L3/021 ,  B01L3/502715 ,  B01L2200/027 ,  B01L2200/0647 ,  B01L2200/12 ,  B01L2300/0816 ,  B01L2300/12 ,  B01L2400/0487 ,  B01L2400/086

摘要： The presently disclosed subject matter provides dual-depth thermoplastic microfluidic devices, related kits, microfluidic systems comprising the dual-depth thermoplastic microfluidic device, methods of isolating nucleic acid analytes from a liquid sample, and methods of isolating extracellular vesicles from a liquid sample.

公开(公告)号：US11865541B2

公开(公告)日：2024-01-09

申请号：US18079860

申请日：2022-12-12

申请人： BioFluidica, Inc.

发明人： Rolf Muller ,  Mateusz Hupert

IPC分类号： B01L3/00 ,  B01L3/02

CPC分类号： B01L3/502753 ,  B01L3/021 ,  B01L3/502715 ,  B01L2200/027 ,  B01L2200/0647 ,  B01L2200/12 ,  B01L2300/0816 ,  B01L2300/12 ,  B01L2400/0487 ,  B01L2400/086

摘要： The presently disclosed subject matter provides dual-depth thermoplastic microfluidic devices, related kits, microfluidic systems comprising the dual-depth thermoplastic microfluidic device, methods of isolating nucleic acid analytes from a liquid sample, and methods of isolating extracellular vesicles from a liquid sample.