公开(公告)号：US11959060B1

公开(公告)日：2024-04-16

申请号：US16875897

申请日：2020-05-15

申请人： Humacyte, Inc.

发明人： Heather L. Prichard ,  Dustin Cashman ,  Joshua McCall ,  Laura E. Niklason ,  Benjamin Orbon ,  Justin T. Strader

IPC分类号： C12M1/00 ,  C12M1/34

CPC分类号： C12M29/14 ,  C12M23/14 ,  C12M29/26 ,  C12M41/12 ,  C12M41/40

摘要： Embodiments of the present disclosure are directed to systems, apparatuses, devices and methods for tissue cultivating. Such systems may comprise a plurality of bioreactors, each bioreactor comprising a bag having a mandrel tube arranged therein, and a fluid management system for managing fluid flow among the plurality of bioreactors. The fluid management system can include at least one intra-luminal pump, configured to flow intra-luminal fluid in a first direction in the bioreactors, at least one media pump, configured to flow biomedia fluid in the bioreactors in a second direction opposite to the first direction, and a plurality of valves and/or clamps to effect at least one of filling, flowing, cessation of flow, and draining of at least one of the intra-luminal fluid and biomedia fluid tubes among the bioreactors.

公开(公告)号：US12104148B1

公开(公告)日：2024-10-01

申请号：US16875907

申请日：2020-05-15

申请人： Humacyte, Inc.

发明人： Robert Schutte ,  Amanda Elizabeth Basciano ,  Dustin Cashman ,  Joshua McCall ,  Laura E. Niklason ,  Heather L Prichard ,  Justin T. Strader

IPC分类号： C12M3/00 ,  C12M1/00 ,  C12M1/34 ,  C12M1/42

CPC分类号： C12M21/08 ,  C12M23/58 ,  C12M29/12 ,  C12M29/14 ,  C12M35/04 ,  C12M41/40

摘要： Embodiments of the present disclosure are directed to apparatuses and methods for a pulsing system which can be configured to provide pressure pulses to a fluid communication tube to/from a bioreactor (for example). Such a system may comprise one or more of, and preferably a plurality of a pulsing motor, a compression plate, one or more fluid communications tubes comprising a biomedia fluid tube configured to direct biomedia fluid into and out of one or more bioreactors, and/or an intra-luminal fluid tube configured to direct intra-luminal fluid through a mandrel tube provided in each bioreactor, and one and/or another of a cam, gearing, and/or actuator configured to repetitively moving the compression plate so as to repetitively compress and release at least a portion of a respective intra-luminal fluid tube for a respective bioreactor to effect a temporary pressure increase (distension or strain) in a respective mandrel-tube according to the predetermined time period.