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1.发明授权公开(公告)号：US11959060B1
公开(公告)日：2024-04-16
申请号：US16875897
申请日：2020-05-15
申请人： Humacyte, Inc.
发明人： Heather L. Prichard , Dustin Cashman , Joshua McCall , Laura E. Niklason , Benjamin Orbon , Justin T. Strader
摘要： Embodiments of the present disclosure are directed to systems, apparatuses, devices and methods for tissue cultivating. Such systems may comprise a plurality of bioreactors, each bioreactor comprising a bag having a mandrel tube arranged therein, and a fluid management system for managing fluid flow among the plurality of bioreactors. The fluid management system can include at least one intra-luminal pump, configured to flow intra-luminal fluid in a first direction in the bioreactors, at least one media pump, configured to flow biomedia fluid in the bioreactors in a second direction opposite to the first direction, and a plurality of valves and/or clamps to effect at least one of filling, flowing, cessation of flow, and draining of at least one of the intra-luminal fluid and biomedia fluid tubes among the bioreactors.
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公开(公告)号：US10934522B2
公开(公告)日：2021-03-02
申请号：US15974195
申请日：2018-05-08
申请人： Humacyte, Inc.
发明人： Shannon L. M. Dahl , Laura E. Niklason , Justin T. Strader , William E. Tente , Joseph J. Lundquist
IPC分类号： C12N5/00 , A61L27/34 , A61F2/06 , A61F2/04 , B29C53/00 , B29C53/36 , A61L27/16 , A61L27/18 , A61L27/36 , A61L27/38 , A61L27/54 , A61L27/58 , B29K67/00 , B29K105/00 , B29L23/00 , B29L31/00
摘要： The present invention provides constructs including a tubular biodegradable polyglycolic acid scaffold, wherein the scaffold may be coated with extracellular matrix proteins and substantially acellular. The constructs can be utilized as an arteriovenous graft, a coronary graft, a peripheral artery bypass conduit, or a urinary conduit. The present invention also provides methods of producing such constructs.
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公开(公告)号：US10947498B2
公开(公告)日：2021-03-16
申请号：US16007322
申请日：2018-06-13
申请人： Humacyte, Inc.
发明人： Shannon L. M. Dahl , Laura E. Niklason , Justin T. Strader , William E. Tente , Joseph J. Lundquist
IPC分类号： C12N5/00 , A61L27/34 , A61F2/06 , A61F2/04 , B29C53/00 , B29C53/36 , A61L27/16 , A61L27/18 , A61L27/36 , A61L27/38 , A61L27/54 , A61L27/58 , B29K67/00 , B29K105/00 , B29L23/00 , B29L31/00
摘要： The present invention provides constructs including a tubular biodegradable polyglycolic acid scaffold, wherein the scaffold may be coated with extracellular matrix proteins and substantially acellular. The constructs can be utilized as an arteriovenous graft, a coronary graft, a peripheral artery bypass conduit, or a urinary conduit. The present invention also provides methods of producing such constructs.
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公开(公告)号：US09650603B2
公开(公告)日：2017-05-16
申请号：US14495310
申请日：2014-09-24
申请人： Humacyte, Inc.
发明人： Shannon L. M. Dahl , Laura E. Niklason , Justin T. Strader , William E. Tente , Joseph J. Lundquist
IPC分类号： A61F2/06 , C12N5/00 , A61F2/04 , B29C53/00 , B29C53/36 , A61L27/34 , B29K67/00 , B29K105/00 , B29L23/00 , B29L31/00
CPC分类号： C12N5/0068 , A61F2/04 , A61F2/06 , A61F2002/047 , A61F2002/048 , A61L27/16 , A61L27/18 , A61L27/34 , A61L27/3633 , A61L27/38 , A61L27/3895 , A61L27/54 , A61L27/58 , B29C53/005 , B29C53/36 , B29K2067/043 , B29K2105/256 , B29K2995/0056 , B29K2995/006 , B29L2023/00 , B29L2031/7532 , C12N2533/30 , C12N2533/40 , Y10T156/1038 , C08L67/04
摘要： The present invention provides constructs including a tubular biodegradable polyglycolic acid scaffold, wherein the scaffold may be coated with extracellular matrix proteins and substantially acellular. The constructs can be utilized as an arteriovenous graft, a coronary graft, a peripheral artery bypass conduit, or a urinary conduit. The present invention also provides methods of producing such constructs.
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公开(公告)号：US20140356323A1
公开(公告)日：2014-12-04
申请号：US14461644
申请日：2014-08-18
申请人： Humacyte, Inc.
发明人： Laura E. Niklason , Yuling Li , Juliana Blum , Shannon L.M. Dahl , Geoffrey Erickson , Frank Zeigler
IPC分类号： A61K38/39
CPC分类号： A61K38/39 , A61K8/00 , A61K8/64 , A61K8/65 , A61K8/735 , A61K2300/00 , A61K2800/86 , A61K2800/91
摘要： The present invention provides compositions comprising isolated human collagen, isolated human elastin and a pharmaceutically acceptable carrier wherein the human elastin is substantially insoluble in water with a molecular weight greater than 100 kDa. The present invention further provides methods and kits for soft tissue augmentation.
摘要翻译： 本发明提供包含分离的人胶原，分离的人弹性蛋白和药学上可接受的载体的组合物，其中人弹性蛋白基本上不溶于分子量大于100kDa的水中。 本发明还提供了用于软组织增强的方法和试剂盒。
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公开(公告)号：US12104148B1
公开(公告)日：2024-10-01
申请号：US16875907
申请日：2020-05-15
申请人： Humacyte, Inc.
发明人： Robert Schutte , Amanda Elizabeth Basciano , Dustin Cashman , Joshua McCall , Laura E. Niklason , Heather L Prichard , Justin T. Strader
摘要： Embodiments of the present disclosure are directed to apparatuses and methods for a pulsing system which can be configured to provide pressure pulses to a fluid communication tube to/from a bioreactor (for example). Such a system may comprise one or more of, and preferably a plurality of a pulsing motor, a compression plate, one or more fluid communications tubes comprising a biomedia fluid tube configured to direct biomedia fluid into and out of one or more bioreactors, and/or an intra-luminal fluid tube configured to direct intra-luminal fluid through a mandrel tube provided in each bioreactor, and one and/or another of a cam, gearing, and/or actuator configured to repetitively moving the compression plate so as to repetitively compress and release at least a portion of a respective intra-luminal fluid tube for a respective bioreactor to effect a temporary pressure increase (distension or strain) in a respective mandrel-tube according to the predetermined time period.
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公开(公告)号：US09657265B2
公开(公告)日：2017-05-23
申请号：US14495339
申请日：2014-09-24
申请人： Humacyte, Inc.
发明人： Shannon L. M. Dahl , Laura E. Niklason , Juliana Blum , Justin T. Strader , William E. Tente , Heather L. Prichard , Joseph J. Lundquist
IPC分类号： A61F2/06 , C12N5/00 , A61F2/04 , B29C53/00 , B29C53/36 , A61L27/34 , B29K67/00 , B29K105/00 , B29L23/00 , B29L31/00
CPC分类号： C12N5/0068 , A61F2/04 , A61F2/06 , A61F2002/047 , A61F2002/048 , A61L27/16 , A61L27/18 , A61L27/34 , A61L27/3633 , A61L27/38 , A61L27/3895 , A61L27/54 , A61L27/58 , B29C53/005 , B29C53/36 , B29K2067/043 , B29K2105/256 , B29K2995/0056 , B29K2995/006 , B29L2023/00 , B29L2031/7532 , C12N2533/30 , C12N2533/40 , Y10T156/1038 , C08L67/04
摘要： The present invention provides constructs including a tubular biodegradable polyglycolic acid scaffold, wherein the scaffold may be coated with extracellular matrix proteins and substantially acellular. The constructs can be utilized as an arteriovenous graft, a coronary graft, a peripheral artery bypass conduit, or a urinary conduit. The present invention also provides methods of producing such constructs.
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公开(公告)号：US10363124B2
公开(公告)日：2019-07-30
申请号：US15512532
申请日：2015-09-18
申请人： HUMACYTE, INC.
发明人： George C. Engelmayr, Jr. , Laura E. Niklason , Shannon L. Dahl , Justin T. Strader , Jinlin Zhang , Stuart Irwin
IPC分类号： A61F2/06 , A61L27/56 , A61L27/58 , B29C67/00 , D04H5/02 , A61L27/18 , D04H18/02 , B29C53/40 , B29K67/00 , B29K105/00 , B29L23/00 , B29L31/00 , B29C53/42 , B29C53/46
摘要： Embodiments of the present disclosure are directed to apparatuses and methods for fabricating tubular structures from a combination of fibrous materials for use in, for example, tissue engineering scaffold applications. These materials may also be useful in other biological or non-biological applications in which such tubular fibrous structures may be applicable, examples including conventional medical devices, filters, fiber optics, cable wraps, geotextiles, batteries, fuel cells, armor, and other diverse applications.
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公开(公告)号：US20170306292A1
公开(公告)日：2017-10-26
申请号：US15595560
申请日：2017-05-15
申请人： Humacyte, Inc.
发明人： Shannon L.M. DAHL , Laura E. Niklason , Justin T. Strader , William E. Tente , Joseph J. Lundquist
IPC分类号： C12N5/00 , A61F2/06 , B29C53/00 , B29C53/36 , A61F2/04 , A61L27/34 , B29L31/00 , B29K105/00 , B29K67/00 , B29L23/00
摘要： The present invention provides constructs including a tubular biodegradable polyglycolic acid scaffold, wherein the scaffold may be coated with extracellular matrix proteins and substantially acellular. The constructs can be utilized as an arteriovenous graft, a coronary graft, a peripheral artery bypass conduit, or a urinary conduit. The present invention also provides methods of producing such constructs.
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