公开(公告)号：US12097289B2

公开(公告)日：2024-09-24

申请号：US17135646

申请日：2020-12-28

Applicant: GLOBAL HEALTH SOLUTIONS LLC

Inventor： Bradley Burnam

IPC: A61K9/10 ,  A61K8/00 ,  A61K8/04 ,  A61K8/31 ,  A61K9/00 ,  A61K9/06 ,  A61K31/785 ,  A61K38/18 ,  A61K38/20 ,  A61K45/06 ,  A61K47/06 ,  A61Q19/00

CPC classification number: A61K9/10 ,  A61K8/00 ,  A61K8/044 ,  A61K8/31 ,  A61K9/0014 ,  A61K9/06 ,  A61K31/785 ,  A61K38/1825 ,  A61K38/1841 ,  A61K38/20 ,  A61K45/06 ,  A61K47/06 ,  A61Q19/00 ,  A61K2800/10

Abstract: The disclosure provides stable formulations of cationic biocides that are primarily used in the treatment and prevention of infections. The disclosure is also concerned with processes for forming stable emulsions of cationic biocides and petrolatum.

公开(公告)号：US11964043B2

公开(公告)日：2024-04-23

申请号：US17362206

申请日：2021-06-29

Applicant: SHISEIDO COMPANY, LTD.

Inventor： Yuki Sugiyama ,  Ryushi Fukuhara ,  Yang Han

IPC: A61K8/91 ,  A61K8/00 ,  A61K8/06 ,  A61K8/81 ,  A61K8/86 ,  A61Q1/00 ,  A61Q5/00 ,  A61Q17/04 ,  A61Q19/00 ,  C08F290/06

CPC classification number: A61K8/91 ,  A61K8/00 ,  A61K8/06 ,  A61K8/068 ,  A61K8/81 ,  A61K8/86 ,  A61Q1/00 ,  A61Q5/00 ,  A61Q17/04 ,  A61Q19/00 ,  C08F290/06 ,  C08F290/062

Abstract: A method of emulsification of an oil phase in an aqueous continuous phase, by dispersing core-corona microparticles into the aqueous phase, adding the oil phase, and applying shearing force for a time sufficient to emulsify the resulting mixture. The core-corona microparticles are obtained by radical co-polymerization of a polyethylene oxide macromonomer with at least one hydrophobic acrylate monomer and at least one hydrophobic acrylamide monomer.

公开(公告)号：US20230181702A1

公开(公告)日：2023-06-15

申请号：US18173991

申请日：2023-02-24

Applicant: IPSEN BIOPHARM LIMITED

Inventor： Anders JARSTAD ,  Anna FRIIS ,  Ulf STAHL ,  Ann GURELL ,  Barbro AGREN ,  Emilia EDSTROM ,  Andrew PICKETT

IPC: A61K38/48 ,  A61K47/02 ,  A61K47/18 ,  A61K47/26 ,  A61K8/39 ,  A61K8/49 ,  A61K8/66 ,  A61Q19/08 ,  A61K9/00 ,  A61K8/19 ,  A61K8/00

CPC classification number: A61K38/4893 ,  A61K47/02 ,  A61K47/183 ,  A61K47/26 ,  A61K8/39 ,  A61K8/492 ,  A61K8/66 ,  A61Q19/08 ,  A61K9/0019 ,  A61K8/19 ,  A61K8/00

Abstract: The invention relates to stable liquid neurotoxin formulations which are free of animal proteins, comprising a surfactant, an amino acid selected from tryptophan and tyrosine, a buffer comprising sodium, chloride and phosphate ions, which have a pH between 5.5 and 8, and which are stable for 2 months. These compositions are suitable for use in therapy and in particular for administration to a patient to achieve a desired therapeutic or aesthetic effect. The invention also relates to the use of an amino acid selected from tryptophan and tyrosine to protect a proteinaceous neurotoxin from degradation in a liquid composition which is free of animal derived proteins.

公开(公告)号：US20180050080A1

公开(公告)日：2018-02-22

申请号：US15241458

申请日：2016-08-19

Applicant: ADAM M. ROTUNDA

Inventor： ADAM M. ROTUNDA

IPC: A61K38/14 ,  A61K9/00 ,  A61K9/70

CPC classification number: A61K38/14 ,  A61K8/00 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/06 ,  A61K9/7023

Abstract: A composition for displacing loose skin and removing subcutaneous deposits of fatty tissue. The composition includes effective amounts of one or more bleomycin-type drugs that are operative to cause apoptosis in localized fat cells, thus causing permanent eradication of such cells. Loose skin is likewise displaced with dense fibrous tissue produced via selective scarring induced by the active bleomycin-type drugs. The compositions are formulated as creams, lotions, gels, waxes, foams, sprays and the like for selectively applied, local topical application, and may also be administered as a conventional transdermal patch. The compositions may alternatively be formulated to be injected into the skin.

公开(公告)号：US20180042981A1

公开(公告)日：2018-02-15

申请号：US15553693

申请日：2017-02-06

Applicant: CAREGEN CO., LTD.

Inventor： Yong Ji CHUNG ,  Eun Mi KIM ,  Eung-Ji LEE ,  Jan Di KIM

IPC: A61K38/00 ,  A61K38/02 ,  A61Q19/02

CPC classification number: A61K38/005 ,  A61K8/00 ,  A61K8/64 ,  A61K38/02 ,  A61Q19/02 ,  C07K7/08

Abstract: The present invention provides a peptide having skin-whitening activity. The peptide of the present invention exhibits an excellent skin whitening effect by inhibiting melanogenesis, inhibiting the activity of tyrosinase, inhibiting the expression of melanosis-involved factors, and inhibiting melanosome transfer. The peptide of the present invention has excellent skin permeability due to the small size thereof. Excellent activity and stability of the foregoing peptide of the present invention can be very favorably applied to cosmetics.

公开(公告)号：US20170326323A1

公开(公告)日：2017-11-16

申请号：US15528236

申请日：2015-10-29

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： JONATHAN SAYER GRASHOW

IPC: A61M16/06 ,  A61M16/20 ,  A61M16/08 ,  A61K31/00 ,  A61K9/00 ,  A61K8/00

CPC classification number: A61M16/0666 ,  A61K8/00 ,  A61K9/00 ,  A61K31/00 ,  A61K36/185 ,  A61M16/06 ,  A61M16/0633 ,  A61M16/0683 ,  A61M16/0816 ,  A61M16/208 ,  A61M2205/02 ,  A61M2205/0238 ,  A61M2207/00 ,  A61K2300/00

Abstract: An apparatus structured to contact external tissue, such as skin, of a user includes a portion that has a component, which is effective to stimulate keratinocytes in the skin of the user. The portion is structured to directly or indirectly engage the external tissue. The portion can include a coating applied to a surface of the apparatus or, alternately, the portion can include a piece or part of the apparatus that has the component incorporated in its material composition. In one implementation, the component is an agonist of olfactory receptors which are expressed by skin cells, and the component is effective to stimulate the skin cells for enhanced wound healing.

公开(公告)号：US09763923B2

公开(公告)日：2017-09-19

申请号：US15144463

申请日：2016-05-02

Applicant: Samsung Electronics Co., Ltd.

Inventor： Jungwon Keum ,  Joontae Park ,  Chulwon Jung ,  Sangchul Park ,  Youngsam Lee

IPC: A61K31/4439 ,  A61K31/428 ,  A61K31/437 ,  A61K8/00

CPC classification number: A61K31/4439 ,  A61K8/00 ,  A61K8/66 ,  A61K31/428 ,  A61K31/437 ,  A61Q19/08

Abstract: Provided is a method of reducing senescence in a cell or subject, or treating or preventing a symptom or disease associated therewith, by administering a BRAF inhibitor to the cell or subject.

公开(公告)号：US09106684B1

公开(公告)日：2015-08-11

申请号：US14298477

申请日：2014-06-06

Applicant: JPMorgan Chase Bank, N.A.

Inventor： Jeffrey D. DiMuro

IPC: H04L29/06 ,  G06F21/56

CPC classification number: H04L63/1408 ,  A61K8/00 ,  A61Q11/00 ,  G06F21/56 ,  G06F21/566 ,  H04L63/02 ,  H04L63/126 ,  H04L63/1425

Abstract: Systems and methods for packet profiling are disclosed. According to one embodiment, a method for profiling incoming data packets for an organization includes the steps of (1) receiving, at an interface for a transport provider, a data packet; (2) using a computer processor, analyzing the data packet; (3) using the computer processor, based on the analysis, marking the data packet; and (4) transmitting the data packet to the organization.

Abstract translation: 公开了用于分组分析的系统和方法。 根据一个实施例，用于对组织的输入数据分组进行分析的方法包括以下步骤：（1）在传输提供商的接口处接收数据分组; （2）使用计算机处理器分析数据包; （3）使用计算机处理器，根据分析，对数据包进行标记; （4）将数据包发送给组织。

公开(公告)号：US20140103635A1

公开(公告)日：2014-04-17

申请号：US14115878

申请日：2012-04-25

Applicant: Urs Lehmann ,  Daniel Heizler

Inventor： Urs Lehmann ,  Daniel Heizler

IPC: C09D11/10 ,  C07F15/00 ,  B42D15/00 ,  C07F15/04

CPC classification number: C07F15/045 ,  A61K8/00 ,  A61K8/19 ,  A61K8/49 ,  A61K8/69 ,  A61K2800/522 ,  A61K2800/524 ,  A61K2800/58 ,  A61Q17/04 ,  B42D25/29 ,  C07F9/005 ,  C07F15/00 ,  C07F15/0066 ,  C07F15/0093 ,  C07F15/04 ,  C09D11/00 ,  C09D11/10 ,  C09D11/50

Abstract: The present invention relates to specific metal complexes of dithiolenes with perfluoroalkyl substituted imidazolidine-2-chalcogenone-4,5-dithione ligands, a process for their preparation and their use as colourless IR absorbers, for optical filters application; especially for plasma display panels, or for laser welding of plastics. The compounds may be used in compositions for inks, paints and plastics, especially in a wide variety of printing systems and are particularly well-suited for security applications.

Abstract translation: 本发明涉及具有全氟烷基取代的咪唑烷-2-硫属元素-4,5-二硫配体的二硫代烯的具体金属络合物，其制备方法及其作为无色IR吸收剂的用途，用于光学滤器应用; 特别是用于等离子体显示面板，或用于激光焊接塑料。 这些化合物可用于油墨，油漆和塑料的组合物中，特别是在各种各样的印刷系统中，特别适用于安全应用。

公开(公告)号：US20110300199A1

公开(公告)日：2011-12-08

申请号：US13201374

申请日：2010-02-16

Applicant: Nuria Garcia Sanz ,  Wim Van Den Nest ,  Cristina Carreno Serraima ,  Antonio Ferrer Montiel ,  Juan Cebrian Puche ,  Nuria Alminana Domenech

Inventor： Nuria Garcia Sanz ,  Wim Van Den Nest ,  Cristina Carreno Serraima ,  Antonio Ferrer Montiel ,  Juan Cebrian Puche ,  Nuria Alminana Domenech

IPC: A61K38/06 ,  C07K5/103 ,  C07K5/11 ,  C07K7/06 ,  C07K5/083 ,  C07K5/087 ,  C07K5/09 ,  C07K1/02 ,  C07K1/04 ,  A61K38/07 ,  A61K38/08 ,  A61K9/127 ,  A61K9/50 ,  A61K9/51 ,  A61K9/48 ,  A61K9/38 ,  A61K8/64 ,  A61K36/00 ,  A61P35/00 ,  A61P35/04 ,  A61P17/06 ,  A61Q19/08 ,  A61Q19/00 ,  A61Q19/06 ,  A61P17/02 ,  A61P29/00 ,  A61P17/10 ,  A61P3/00 ,  A61P9/00 ,  A61P23/00 ,  A61Q15/00 ,  A61P31/04 ,  A61P31/10 ,  A61P31/00 ,  A61P31/12 ,  A61P1/08 ,  A61P3/02 ,  A61K38/43 ,  A61P33/00 ,  A61P39/06 ,  A61Q19/04 ,  A61Q19/02 ,  A61Q1/00 ,  C07K5/107

CPC classification number: A61K38/00 ,  A61K8/00 ,  A61K8/64 ,  A61K38/04 ,  A61K38/07 ,  A61K38/08 ,  A61Q19/00 ,  A61Q19/08 ,  C07K5/0812 ,  C07K5/101 ,  C07K5/1016 ,  C07K5/1019 ,  C07K7/04 ,  C07K7/06

Abstract: Peptides of general formula (I): R1-Wp-Xn-AA1-AA2-AA3-AA4-Ym-R2 their stereoisomers, mixtures thereof, and/or their cosmetically or pharmaceutically acceptable salts, a method of preparation, cosmetic or pharmaceutical compositions containing them and their use for the treatment, prevention and/or care of conditions, disorders and/or diseases of the skin, mucous membranes and/or scalp.

Abstract translation: 通式（I）的肽：R1-Wp-Xn-AA1-AA2-AA3-AA4-Ym-R2其立体异构体，其混合物和/或其化妆品或药学上可接受的盐，制备方法，化妆品或药物组合物 含有它们及其用于治疗，预防和/或护理皮肤，粘膜和/或头皮的病症，障碍和/或疾病的用途。