公开(公告)号：US20240050539A1

公开(公告)日：2024-02-15

申请号：US18476731

申请日：2023-09-28

Applicant: IPSEN BIOPHARM LIMITED

Inventor： Anders JARSTAD ,  Anna FRIIS ,  Ulf STAHL ,  Ann GURELL ,  Barbro AGREN ,  Emilia EDSTROM ,  Andrew PICKETT

IPC: A61K38/48 ,  A61K47/02 ,  A61K47/18 ,  A61K47/26 ,  A61K8/39 ,  A61K8/49 ,  A61K8/66 ,  A61Q19/08 ,  A61K9/00 ,  A61K8/19 ,  A61K8/00

CPC classification number: A61K38/4893 ,  A61K47/02 ,  A61K47/183 ,  A61K47/26 ,  A61K8/39 ,  A61K8/492 ,  A61K8/66 ,  A61Q19/08 ,  A61K9/0019 ,  A61K8/19 ,  A61K8/00

Abstract: The invention relates to stable liquid neurotoxin formulations which are free of animal proteins, comprising a surfactant, an amino acid selected from tryptophan and tyrosine, a buffer comprising sodium, chloride and phosphate ions, which have a pH between 5.5 and 8, and which are stable for 2 months. These compositions are suitable for use in therapy and in particular for administration to a patient to achieve a desired therapeutic or aesthetic effect. The invention also relates to the use of an amino acid selected from tryptophan and tyrosine to protect a proteinaceous neurotoxin from degradation in a liquid composition which is free of animal derived proteins.

公开(公告)号：US20190183988A1

公开(公告)日：2019-06-20

申请号：US16304986

申请日：2017-05-26

Applicant: IPSEN BIOPHARM LIMITED ,  NESTLE SKIN HEALTH SA

Inventor： Anders JARSTAD ,  Anna FRIIS ,  Ulf STAHL ,  Ann GURELL ,  Barbro AGREN ,  Emilia EDSTROM ,  Andrew PICKETT

IPC: A61K38/48 ,  A61K47/18 ,  A61K47/02 ,  A61K47/26 ,  A61K8/19 ,  A61K8/39 ,  A61K8/49 ,  A61K8/66 ,  A61K9/00 ,  A61Q19/08

CPC classification number: A61K38/4893 ,  A61K8/00 ,  A61K8/19 ,  A61K8/39 ,  A61K8/492 ,  A61K8/66 ,  A61K9/0019 ,  A61K47/02 ,  A61K47/183 ,  A61K47/26 ,  A61Q19/08

Abstract: The invention relates to stable liquid neurotoxin formulations which are free of animal proteins, comprising a surfactant, an amino acid selected from tryptophan and tyrosine, a buffer comprising sodium, chloride and phosphate ions, which have a pH between 5.5 and 8, and which are stable for 2 months. These compositions are suitable for use in therapy and in particular for administration to a patient to achieve a desired therapeutic or aesthetic effect. The invention also relates to the use of an amino acid selected from tryptophan and tyrosine to protect a proteinaceous neurotoxin from degradation in a liquid composition which is free of animal derived proteins.

公开(公告)号：US20230181702A1

公开(公告)日：2023-06-15

申请号：US18173991

申请日：2023-02-24

Applicant: IPSEN BIOPHARM LIMITED

Inventor： Anders JARSTAD ,  Anna FRIIS ,  Ulf STAHL ,  Ann GURELL ,  Barbro AGREN ,  Emilia EDSTROM ,  Andrew PICKETT

IPC: A61K38/48 ,  A61K47/02 ,  A61K47/18 ,  A61K47/26 ,  A61K8/39 ,  A61K8/49 ,  A61K8/66 ,  A61Q19/08 ,  A61K9/00 ,  A61K8/19 ,  A61K8/00

CPC classification number: A61K38/4893 ,  A61K47/02 ,  A61K47/183 ,  A61K47/26 ,  A61K8/39 ,  A61K8/492 ,  A61K8/66 ,  A61Q19/08 ,  A61K9/0019 ,  A61K8/19 ,  A61K8/00

Abstract: The invention relates to stable liquid neurotoxin formulations which are free of animal proteins, comprising a surfactant, an amino acid selected from tryptophan and tyrosine, a buffer comprising sodium, chloride and phosphate ions, which have a pH between 5.5 and 8, and which are stable for 2 months. These compositions are suitable for use in therapy and in particular for administration to a patient to achieve a desired therapeutic or aesthetic effect. The invention also relates to the use of an amino acid selected from tryptophan and tyrosine to protect a proteinaceous neurotoxin from degradation in a liquid composition which is free of animal derived proteins.

公开(公告)号：US20230190892A9

公开(公告)日：2023-06-22

申请号：US17304888

申请日：2021-06-28

Applicant: IPSEN BIOPHARM LIMITED

Inventor： Anders JARSTAD ,  Anna FRIIS ,  Ulf STAHL ,  Ann GURELL ,  Barbro AGREN ,  Emilia EDSTROM ,  Andrew PICKETT

IPC: A61K38/48 ,  A61K47/02 ,  A61K47/18 ,  A61K47/26 ,  A61K8/39 ,  A61K8/49 ,  A61K8/66 ,  A61Q19/08 ,  A61K9/00 ,  A61K8/19 ,  A61K8/00

CPC classification number: A61K38/4893 ,  A61K47/02 ,  A61K47/183 ,  A61K47/26 ,  A61K8/39 ,  A61K8/492 ,  A61K8/66 ,  A61Q19/08 ,  A61K9/0019 ,  A61K8/19 ,  A61K8/00

Abstract: The invention relates to stable liquid neurotoxin formulations which are free of animal proteins, comprising a surfactant, an amino acid selected from tryptophan and tyrosine, a buffer comprising sodium, chloride and phosphate ions, which have a pH between 5.5 and 8, and which are stable for 2 months. These compositions are suitable for use in therapy and in particular for administration to a patient to achieve a desired therapeutic or aesthetic effect. The invention also relates to the use of an amino acid selected from tryptophan and tyrosine to protect a proteinaceous neurotoxin from degradation in a liquid composition which is free of animal derived proteins.

公开(公告)号：US20210330765A1

公开(公告)日：2021-10-28

申请号：US17304888

申请日：2021-06-28

Applicant: IPSEN BIOPHARM LIMITED

Inventor： Anders JARSTAD ,  Anna FRIIS ,  Ulf STAHL ,  Ann GURELL ,  Barbro AGREN ,  Emilia EDSTROM ,  Andrew PICKETT

IPC: A61K38/48 ,  A61K47/02 ,  A61K47/18 ,  A61K47/26 ,  A61K8/39 ,  A61K8/49 ,  A61K8/66 ,  A61Q19/08 ,  A61K9/00 ,  A61K8/19 ,  A61K8/00

Abstract: The invention relates to stable liquid neurotoxin formulations which are free of animal proteins, comprising a surfactant, an amino acid selected from tryptophan and tyrosine, a buffer comprising sodium, chloride and phosphate ions, which have a pH between 5.5 and 8, and which are stable for 2 months. These compositions are suitable for use in therapy and in particular for administration to a patient to achieve a desired therapeutic or aesthetic effect. The invention also relates to the use of an amino acid selected from tryptophan and tyrosine to protect a proteinaceous neurotoxin from degradation in a liquid composition which is free of animal derived proteins.