公开(公告)号：US20240263117A1

公开(公告)日：2024-08-08

申请号：US18683715

申请日：2022-08-16

申请人： Nagi Bioscience SA

发明人： Matteo CORNAGLIA ,  Fabien TACHE

IPC分类号： C12M3/06 ,  B01L3/00 ,  C12M1/00 ,  C12M1/12 ,  C12M3/00 ,  G02B21/00 ,  G06T7/00

CPC分类号： C12M23/16 ,  B01L3/502723 ,  C12M23/34 ,  C12M23/48 ,  C12M25/10 ,  C12M27/16 ,  C12M31/00 ,  G02B21/0004 ,  G06T7/0012 ,  B01L2200/0684 ,  G06T2207/10056

摘要： Microscopic biological organism culture and observation apparatus (1) comprising a support structure (10), one or more chip holders (3) mounted on the support structure, a pump (P) and a valve system (V), each chip holder configured for holding a microfluidic chip (2) having one or more microfluidic channels (54) and culture chambers (52) therein extending between a pump coupling side (44a) of the microfluidic chip and a reservoir side coupling (44b) of the microfluidic chip. The support structure comprises a reservoirs support platform (7) mounted on a movable table (12), the reservoirs support platform (7) configured for holding a plurality of nutrition reservoirs (5) for containing microscopic biological organisms or nutrients and substances to be tested in a liquid. The chip holder (3) and/or microfluidic chips (2) comprise reservoir side fluidic couplings (26) in the form of hollow tubes extending from the microfluidic chip (2) to a tip (26b) at a free end of the hollow tube, each tip (26b) insertable in a corresponding nutrition reservoir

公开(公告)号：US20180273900A1

公开(公告)日：2018-09-27

申请号：US15761375

申请日：2016-09-23

申请人： ASOCIACIÓN CENTRO DE INVESTIGACIÓN COOPERATIVA EN BIOMATERIALES - CIC BIOMAGUNE

发明人： Luis Manuel LIZ-MARZÁN ,  Juan José GINER CASARES ,  Malou HENRIKSEN-LACEY ,  Alexander JOHNSON

IPC分类号： C12N5/00 ,  C12M1/12 ,  C12M1/00

CPC分类号： C12N5/0068 ,  C12M25/00 ,  C12M31/00 ,  C12N2529/10 ,  C12N2533/00 ,  C12N2533/10 ,  C12N2535/00 ,  C12N2539/00 ,  C12N2539/10

摘要： There is provided an adherent cell-culture support comprising gold nanoparticles on the surface where the cells attach to, wherein the size of the nanoparticles is from 5 nm to 2 microns, the distance between the nanoparticles is from 2 nm to 30 nm and the anisotropy aspect ratio is greater than 1. These substrates have improved properties for allowing the culturing and subsequent detachment of cells, with potential applications in a wide range of fields such as stem cell research and tissue engineering. There is also provided a process for their preparation and several uses thereof.

公开(公告)号：US09683989B2

公开(公告)日：2017-06-20

申请号：US14512557

申请日：2014-10-13

申请人： Technion Research & Development Foundation Limited

发明人： Shy Shoham ,  Anat Marom ,  Sanjeev Kumar Mahto

IPC分类号： C12M1/34 ,  G01N33/50 ,  A61N5/06 ,  A61K35/30 ,  C12M1/00 ,  C12N5/0793 ,  A61B17/11 ,  A61L27/38 ,  A61L27/52

CPC分类号： G01N33/5058 ,  A61B17/1128 ,  A61F2230/0063 ,  A61K35/30 ,  A61L27/383 ,  A61L27/52 ,  A61N5/0622 ,  C12M31/00 ,  C12N5/0619 ,  C12N5/062 ,  C12N2501/13 ,  C12N2501/33 ,  C12N2503/04 ,  C12N2510/00 ,  C12N2513/00 ,  C12N2533/90

摘要： A neural network is disclosed. The neural network comprises a plurality of optogenetically modified neural cells being three-dimensionally distributed in a hydrogel medium and being disconnected from any solid support having a shear modulus above 1 GPa.

公开(公告)号：US20160319231A1

公开(公告)日：2016-11-03

申请号：US15109944

申请日：2015-01-06

申请人： SABIC GLOBAL TECHNOLOGIES B.V.

发明人： Suresh Velate ,  Ihab Nizar Odeh ,  Duncan Rowe

IPC分类号： C12M1/00

CPC分类号： C12M21/02 ,  C12M23/20 ,  C12M23/22 ,  C12M31/00 ,  C12M31/08

摘要： Disclosed is a wavelength conversion material for use in a photo-bioreactor for growing phototrophic organisms. The wavelength conversion material includes an organic fluorescent dye and a polymeric matrix, wherein the organic fluorescent dye is solubilized in the polymeric matrix. The wavelength-conversion material is capable of absorbing light comprising a wavelength of 280 to 650 nm and emitting the absorbed light at a wavelength of 400 to 800 nm.

摘要翻译： 公开了用于生长光生物的光生物反应器中的波长转换材料。 波长转换材料包括有机荧光染料和聚合物基质，其中有机荧光染料溶解在聚合物基质中。 波长转换材料能够吸收波长为280至650nm的光并且发射波长为400至800nm的吸收光。

公开(公告)号：US20160137997A1

公开(公告)日：2016-05-19

申请号：US15006712

申请日：2016-01-26

申请人： Enwave Corporation

发明人： Timothy D. Durance ,  Jun Fu

IPC分类号： C12N9/36 ,  C12M1/34 ,  C12M1/00

CPC分类号： C12N9/2462 ,  C12M21/14 ,  C12M31/00 ,  C12M41/40 ,  C12M47/14 ,  C12N1/04 ,  C12N9/98 ,  C12N13/00 ,  C12Y302/01017 ,  F26B1/005 ,  F26B5/048 ,  F26B5/065 ,  F26B11/08

摘要： An apparatus and method for microwave vacuum-drying of temperature-sensitive biological materials on a continuous flow-through basis, in which the materials are frozen, ground to frozen particles, dehydrated to a powder, and the powder collected. The apparatus has a microwave generator and waveguide, a freezing chamber with a grinder, a rotatable dehydration chamber in or adjacent to the waveguide, and a powder collector to receive the powdered biological material. The apparatus operates under reduced pressure provided by a vacuum system coupled to the powder collector.

摘要翻译： 在连续流通的基础上对温度敏感的生物材料进行微波真空干燥的装置和方法，其中将材料冷冻，研磨成冷冻颗粒，脱水至粉末，收集粉末。 该装置具有微波发生器和波导，具有研磨机的冷冻室，在波导中或邻近波导的可旋转脱水室，以及用于接收粉末状生物材料的粉末收集器。 该设备在由与粉末收集器连接的真空系统提供的减压下操作。

公开(公告)号：US20160044872A1

公开(公告)日：2016-02-18

申请号：US14779498

申请日：2013-08-09

申请人： DOUBLE CRANE BIOTECHNOLOGY CO., LTD

发明人： Liu-Ming HUANG ,  Chih-Wei CHEN ,  Mon-Tarng CHEN ,  Yen-Chun LU ,  Kuang-Dee CHEN

IPC分类号： A01G1/04 ,  C12M1/00 ,  C12M1/12

CPC分类号： A01G1/04 ,  A01G18/00 ,  A01G18/60 ,  C12M23/04 ,  C12M29/00 ,  C12M31/00 ,  C12N1/14 ,  C12P15/00

摘要： Disclosed herein is an industrial scale process of cultivating cultivating Ganoderma lucidum mycelia. As high as 15 Kg dried Ganoderma lucidum mycelia may be produced from about 300 liters liquid culture every 30 days, and the resulting dried Ganoderma lucidum mycelia are rich in triterpenoids that include at least ganoderic acid S (GAS), ganoderic acid T (GAT), ganoderic acid Me (GAMe), ganoderic acid R (GAR), and ganodermic acid S (GMAS).

摘要翻译： 本文公开了培育灵芝菌丝体的工业规模过程。 高达15千克干灵芝菌丝体可以每30天从约300升液体培养物中生产，所得干灵芝菌丝体富含三萜类化合物，其包括至少甘草酸S（GAS），甘草酸T（GAT） ，甘油酸Me（GAMe），甘油酸R（GAR）和灵芝酸（GMAS）。

公开(公告)号：US08945482B2

公开(公告)日：2015-02-03

申请号：US13126105

申请日：2010-02-12

申请人： Samir Mitragotri ,  Sumit Paliwal ,  Makoto Ogura

发明人： Samir Mitragotri ,  Sumit Paliwal ,  Makoto Ogura

IPC分类号： G01N1/28 ,  A61B10/02 ,  A61M37/00 ,  G01N1/40 ,  A61B10/00 ,  A61B10/04 ,  A61B18/20 ,  A61B17/00 ,  A61B17/32 ,  A61B18/00 ,  A61N7/02 ,  G01N1/44

CPC分类号： A61B10/02 ,  A61B10/0045 ,  A61B10/0096 ,  A61B10/0283 ,  A61B10/04 ,  A61B18/04 ,  A61B18/20 ,  A61B2010/0208 ,  A61B2017/00761 ,  A61B2017/320004 ,  A61B2018/00452 ,  A61K31/522 ,  A61K38/28 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0046 ,  A61N7/00 ,  A61N7/02 ,  A61N2007/0034 ,  C12M23/28 ,  C12M31/00 ,  C12M35/08 ,  G01N1/286 ,  G01N1/4044 ,  G01N1/44 ,  Y10T436/2575

摘要： The current invention provides devices, methods and systems involving application of energy and/or a liquefaction promoting medium to a tissue of interest to generate a liquefied sample comprising tissue constituents so as to provide for rapid tissue sampling, tissue decontamination as well as qualitative and/or quantitative detection of analytes that may be part of tissue constituents (e.g., several types of biomolecules, drugs, and microbes). In addition, the current invention provides specific compositions of the said liquefaction promoting medium so as to facilitate liquefaction, preserve liquefied tissue constituents, and enable delivery of molecules into tissues. Determination of tissue composition in the liquefied tissue sample can be used in a variety of applications, including diagnosis or prognosis of local as well as systemic diseases, evaluating bioavailability of therapeutics in different tissues following drug administration, forensic detection of drugs-of-abuse, evaluating changes in the tissue microenvironment following exposure to a harmful agent, and various other applications. The methods, devices and systems are used to deliver one or more drugs through or into the site of the tissue to be liquefied.

摘要翻译： 本发明提供了涉及将能量和/或液化促进介质施加到感兴趣的组织的装置，方法和系统，以产生包含组织成分的液化样品，以便提供快速组织取样，组织去污以及定性和/ 或定量检测可能是组织成分（例如，几种类型的生物分子，药物和微生物）的分析物。 此外，本发明提供了所述液化促进介质的特定组成，以便于液化，保存液化组织成分，并使分子进入组织。 液体组织样品中组织组成的测定可用于各种应用，包括局部和全身疾病的诊断或预后，药物给药后不同组织中药物的生物利用度，药物滥用药物的法医检测， 评估暴露于有害物质后组织微环境的变化，以及各种其他应用。 方法，装置和系统用于将一种或多种药物通过或进入要液化的组织的部位。

公开(公告)号：US20230309917A1

公开(公告)日：2023-10-05

申请号：US17978077

申请日：2022-10-31

申请人： BIORA THERAPEUTICS, INC.

发明人： Mitchell Lawrence Jones ,  Sharat Singh ,  Christopher Loren Wahl ,  Harry Stylli

IPC分类号： A61B5/00 ,  A61B5/07 ,  C07K16/24 ,  A61M31/00 ,  A61K31/436 ,  A61K38/13 ,  C12M1/00 ,  C12Q1/00

CPC分类号： A61B5/4839 ,  A61B5/0031 ,  A61B5/0075 ,  A61B5/073 ,  C07K16/244 ,  A61M31/002 ,  A61B5/07 ,  A61B5/6861 ,  A61K31/436 ,  A61K38/13 ,  C12M31/00 ,  C12Q1/00 ,  A61B2010/0061

摘要： This disclosure features methods and compositions for treating diseases of the gastrointestinal tract with an immunosuppressant.

公开(公告)号：US11655443B2

公开(公告)日：2023-05-23

申请号：US17733076

申请日：2022-04-29

申请人： Palo Alto Research Center Incorporated

发明人： Michael I. Recht ,  Joerg Martini ,  Peter Kiesel

IPC分类号： C12M1/32 ,  C12M1/34 ,  C12Q1/18 ,  C12Q1/04 ,  C12M1/00 ,  C12M1/02 ,  C12M1/12

CPC分类号： C12M41/12 ,  C12M23/12 ,  C12M23/20 ,  C12M31/00 ,  C12M41/18 ,  C12Q1/04 ,  C12Q1/18 ,  C12M25/14

摘要： A test vessel includes one or more test locations configured to contain a medium suitable for culturing a live substance. A thermochromic material is thermally coupled to the one or more test locations. The thermochromic material is configured to exhibit a spectral shift in light emanating from the thermochromic material in response to an increase or decrease in energy conversion by the live substance that causes a change in temperature of the thermochromic material.

公开(公告)号：US09820443B2

公开(公告)日：2017-11-21

申请号：US14779498

申请日：2013-08-09

申请人： Double Crane Biotechnology Co., LTD

发明人： Li-Ming Huang ,  Chih-Wei Chen ,  Mon-Tarng Chen ,  Yen-Chun Liu ,  Kuang-Dee Chen

IPC分类号： A01G1/04 ,  C12N1/14 ,  C12P15/00 ,  C12M1/12 ,  C12M1/00

CPC分类号： A01G1/04 ,  A01G18/00 ,  A01G18/60 ,  C12M23/04 ,  C12M29/00 ,  C12M31/00 ,  C12N1/14 ,  C12P15/00

摘要： Disclosed herein is an industrial scale process of cultivating cultivating Ganoderma lucidum mycelia. As high as 15 Kg dried Ganoderma lucidum mycelia may be produced from about 300 liters liquid culture every 30 days, and the resulting dried Ganoderma lucidum mycelia are rich in triterpenoids that include at least ganoderic acid S (GAS), ganoderic acid T (GAT), ganoderic acid Me (GAMe), ganoderic acid R (GAR), and ganodermic acid S (GMAS).