公开(公告)号：US12150775B2

公开(公告)日：2024-11-26

申请号：US17978077

申请日：2022-10-31

Applicant: BIORA THERAPEUTICS, INC.

Inventor： Mitchell Lawrence Jones ,  Sharat Singh ,  Christopher Loren Wahl ,  Harry Stylli

IPC: A61K38/13 ,  A61B5/00 ,  A61B5/07 ,  A61K31/436 ,  A61M31/00 ,  C07K16/24 ,  C12M1/00 ,  C12Q1/00 ,  A61B1/00 ,  A61B10/00

Abstract: This disclosure features methods and compositions for treating diseases of the gastrointestinal tract with an immunosuppressant.

公开(公告)号：US12089916B2

公开(公告)日：2024-09-17

申请号：US16827807

申请日：2020-03-24

Applicant: BIORA THERAPEUTICS, INC.

Inventor： Sharat Singh ,  Mitchell Lawrence Jones ,  Christopher Loren Wahl

IPC: A61B5/00 ,  A61B5/07 ,  A61B5/145 ,  A61B10/00 ,  A61K45/06 ,  A61K49/00 ,  C12M1/00 ,  C12N1/20 ,  C12Q1/04 ,  C12Q1/06 ,  C12Q1/10 ,  G01N1/10 ,  G01N1/20 ,  G01N1/38 ,  G01N21/76 ,  G01N33/483 ,  G01N33/487 ,  G01N33/58 ,  A61B5/01 ,  A61B5/03 ,  A61B5/1455

CPC classification number: A61B5/0071 ,  A61B5/073 ,  A61B5/4238 ,  A61B5/4255 ,  A61B5/6861 ,  A61B10/0045 ,  A61K45/06 ,  A61K49/0019 ,  A61K49/0058 ,  C12M29/26 ,  C12N1/20 ,  C12Q1/045 ,  C12Q1/06 ,  C12Q1/10 ,  G01N1/10 ,  G01N1/20 ,  G01N1/38 ,  G01N21/76 ,  G01N33/4833 ,  G01N33/487 ,  G01N33/582 ,  A61B5/0084 ,  A61B5/01 ,  A61B5/036 ,  A61B5/14503 ,  A61B5/14539 ,  A61B5/14546 ,  A61B5/14552 ,  A61B5/42 ,  A61B10/0038 ,  A61B2010/0061 ,  A61B2010/0074 ,  A61B2562/0233 ,  G01N2001/1031

Abstract: The present disclosure relates to gastrointestinal (GI) tract detection methods, devices and systems.

公开(公告)号：US20240252795A1

公开(公告)日：2024-08-01

申请号：US17295282

申请日：2019-11-19

Applicant: BIORA THERAPEUTICS, INC.

Inventor： Jeffrey A. Shimizu ,  Mitchell Lawrence Jones ,  Mark Sasha Drlik ,  Iman Niknia ,  Nathan John Muller ,  Tuyen Nguyen ,  Christopher Loren Wahl ,  Edward Mudge ,  Nicholas Mark Salt ,  Nia Eleri Stevens ,  Stuart Robert Abercrombie ,  Christopher Ian Bunce ,  Nelson Quintana

IPC: A61M31/00 ,  A61K38/17 ,  A61K38/26 ,  A61K38/28 ,  C07K16/24

CPC classification number: A61M31/002 ,  A61K38/1796 ,  A61K38/26 ,  A61K38/28 ,  C07K16/241 ,  A61M2210/106

Abstract: An ingestible device, includes a storage reservoir configured to store a dispensable substance and a pressurized chamber configured so that, when a restraining force is removed from the pressurized clamber, the dispensable substance exits the ingestible device via openings in the ingestible device.

公开(公告)号：US11793420B2

公开(公告)日：2023-10-24

申请号：US16839107

申请日：2020-04-03

Applicant: Biora Therapeutics, Inc.

Inventor： Mitchell Lawrence Jones ,  Christopher Loren Wahl ,  Gene Alan Wey ,  Aaron Olafur Laurence Philippsen ,  Mark Sasha Drlik ,  Ryan Elliott Jones ,  Nathan John Muller ,  Andrew Carlos Garland ,  Iman Niknia

IPC: A61B5/07 ,  A61B1/04 ,  A61M31/00 ,  A61B5/00 ,  A61J3/00

CPC classification number: A61B5/073 ,  A61B1/041 ,  A61M31/002 ,  A61B5/4839 ,  A61J3/007

Abstract: Ingestible devices capable of delivering a dispensable substance, such as, for example, a therapeutic agent, as well as related components, systems and methods, are disclosed. A removably attachable storage reservoir configured to be used with an ingestible device and capable of storing dispensable substance, such as, for example, a therapeutic agent, as well as related components, systems and methods, are also disclosed.

公开(公告)号：US11597762B2

公开(公告)日：2023-03-07

申请号：US16465632

申请日：2017-12-14

Applicant: BIORA THERAPEUTICS, INC.

Inventor： Mitchell Lawrence Jones ,  Sharat Singh ,  Christopher Loren Wahl ,  Harry Stylli

IPC: A61K39/00 ,  C07K16/24 ,  A61P1/00 ,  A61M31/00 ,  A61B5/07

Abstract: This disclosure features methods and compositions for treating diseases of the gastrointestinal tract with an IL-12/IL-23 inhibitor.

公开(公告)号：US20230017603A1

公开(公告)日：2023-01-19

申请号：US17945890

申请日：2022-09-15

Applicant: Biora Therapeutics, Inc.

Inventor： Jeffrey A. SHIMIZU ,  Mitchell Lawrence JONES ,  Mark Sasha DRLIK ,  Iman NIKNIA ,  Nathan John MULLER ,  Tuyen NGUYEN ,  Christopher Loren WAHL ,  Edward MUDGE ,  Nicholas Mark SALT ,  Nia Eleri STEVENS ,  Stuart Robert ABERCROMBIE ,  Christopher Ian BUNCE ,  Ryan Elliott JONES ,  Kevin HOWE ,  Pejman RAHIMIAN ,  Nelson QUINTANA

IPC: A61M31/00

Abstract: Ingestible devices can directly deliver therapeutic agents to desired tissue(s) of the GI tract of a subject, such as the submucosa, the mucosa, and/or the mucus layer of the GI tract, and methods of using the same. The ingestible devices can deliver therapeutic agents in a safe, effective, and reliable manner. The disclosure also provides pharmaceutical compositions for use in methods of treating a disease or condition in a subject in need thereof.

公开(公告)号：US20220273196A1

公开(公告)日：2022-09-01

申请号：US17745549

申请日：2022-05-16

Applicant: Biora Therapeutics, Inc.

Inventor： Ryan Elliott Jones ,  Hamilton Roger Tang ,  Rachel Ellen Gerver ,  Mitchell Lawrence Jones

IPC: A61B5/1459 ,  A61B5/06 ,  A61B5/00 ,  A61B5/1455 ,  A61B5/145 ,  A61B1/00 ,  A61B1/04 ,  A61B5/07 ,  A61M31/00

Abstract: An ingestible device is disclosed which can produce spectral data of one or more analytes, as well as associated methods for characterizing the gastrointestinal tract of a subject which contains such analytes. Related kits and systems are also disclosed.

公开(公告)号：US12227565B2

公开(公告)日：2025-02-18

申请号：US17253804

申请日：2019-06-19

Applicant: Biora Therapeutics, Inc.

Inventor： Mitchell Lawrence Jones ,  Christopher Loren Wahl ,  Sharat Singh ,  Kevin David Howe ,  Arana Perera

IPC: C07K16/24 ,  A61K9/00 ,  A61K39/00 ,  A61P1/00 ,  A61P37/06 ,  C07K16/28

Abstract: This disclosure features methods and compositions for treating inflammatory disorders or conditions that arise in a tissue originating from the endoderm using an immune modulator.

公开(公告)号：US20250000364A1

公开(公告)日：2025-01-02

申请号：US18826061

申请日：2024-09-05

Applicant: BIORA THERAPEUTICS, INC.

Inventor： Sharat Singh ,  Mitchell Lawrence Jones ,  Christopher Loren Wahl

IPC: A61B5/00 ,  A61B5/01 ,  A61B5/03 ,  A61B5/07 ,  A61B5/145 ,  A61B5/1455 ,  A61B10/00 ,  A61K45/06 ,  A61K49/00 ,  C12M1/00 ,  C12N1/20 ,  C12Q1/04 ,  C12Q1/06 ,  C12Q1/10 ,  G01N1/10 ,  G01N1/20 ,  G01N1/38 ,  G01N21/76 ,  G01N33/483 ,  G01N33/487 ,  G01N33/58

Abstract: The present disclosure relates to gastrointestinal (GI) tract detection methods, devices and systems.

公开(公告)号：US20240358273A1

公开(公告)日：2024-10-31

申请号：US18766498

申请日：2024-07-08

Applicant: BIORA THERAPEUTICS, INC.

Inventor： Mitchell Lawrence Jones ,  Alain Labbé ,  Mark Sasha Drlik ,  Christian Terry Proch McMechan

IPC: A61B5/06 ,  A61B1/04 ,  A61B5/00 ,  A61B5/07 ,  H04B10/114 ,  H04B13/00

CPC classification number: A61B5/065 ,  A61B1/041 ,  A61B5/002 ,  A61B5/0086 ,  A61B5/073 ,  A61B5/6861 ,  A61B5/7264 ,  H04B10/1143 ,  H04B13/00 ,  A61B5/0017 ,  A61B2560/0443 ,  A61B2560/0462 ,  A61B2562/162

Abstract: Various embodiments are described herein for a device, system, and method for identifying a location of an ingestible device within a gastrointestinal tract of a body. In some embodiments, the ingestible device includes a sensing unit with an axial optical sensing sub-unit located proximal to at least one end of the device, and a radial optical sensing sub-unit located proximal to a radial wall of the device, and may autonomously identify a location within the gastrointestinal tract. In some embodiments, the ingestible device includes optical illumination sources and detectors that operate at a plurality of different wavelengths, and may discern regions of a gastrointestinal tract by using the reflection properties of organ tissue and occasional particulates. In some embodiments, the ingestible device may sample fluid or release medicament based on a detected device location.