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公开(公告)号：US20250056703A1
公开(公告)日：2025-02-13
申请号：US18790246
申请日：2024-07-31
Inventor： Amnon BALANOV , Ido KAMINER
IPC: H05G2/00
Abstract: An X-ray generator is presented comprising: an electron source generating an accelerated electron beam propagating along a first propagation path with a first general propagation direction; a first crystalline structure located in the first propagation path, and defining a first crystal plane oriented at a predetermined non-zero angle with the first propagation path, and configured to transmit the electron beam therethrough and generate parametric x-ray (PXR) emission being first directional emission along a second propagation path tilted with respect to the first general propagation direction; and a second crystalline structure located in the second propagation path and configured as a monochromator with respect to the PXR emission, and defining a second crystal plane oriented at the predetermined non-zero angle with respect to the second propagation path to thereby provide second directionality for the PXR emission.
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公开(公告)号：US20250051348A1
公开(公告)日：2025-02-13
申请号：US18803753
申请日：2024-08-13
Inventor： Joshua M. GROLMAN , Yifan LIAO , Hang ZHANG , Charles Eliezer DIESENDRUCK
IPC: C07D491/107
Abstract: Mechanophoric compounds featuring one or more, or two or more, clickable group(s), which are capable of being coupled to naturally occurring, synthetic and/or metallic substrates via Click chemistry, method of preparing mechanophoric matrices using the mechanophoric compounds, and mechanophoric matrices obtainable thereby, and uses thereof for detecting force-induced damage in the matrices by a colorimetric change are provided.
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公开(公告)号：US20250041275A1
公开(公告)日：2025-02-06
申请号：US18911431
申请日：2024-10-10
Inventor： Iyad KHAMAYSI , Salim HADAD , Zaid ABASSI
IPC: A61K31/405 , A61K31/194 , A61K31/196 , A61K47/54 , A61P13/12
Abstract: The invention relates generally to the field of compositions including one or more conjugates of di-sugar and a nonsteroidal anti-inflammatory drug (NSAID), and use of same in methods for treating a disease or a disorder in a subject in need thereof.
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公开(公告)号：US12186454B2
公开(公告)日：2025-01-07
申请号：US18100000
申请日：2023-01-23
Inventor： Marcelle Machluf , Eyal Zussman , Limor Baruch
Abstract: A scaffold comprising electrospun decellularized ECM of an organ, wherein the decellularized ECM has a similar protein composition to native ECM of the organ. Methods of generating same are also disclosed as well as uses of same.
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公开(公告)号：US12171568B2
公开(公告)日：2024-12-24
申请号：US17435906
申请日：2020-03-03
Applicant: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED , ICHILOV TECH LTD. , RAMOT AT TEL-AVIV UNIVERSITY LTD.
Inventor： Talma Hendler , Asya Rolls , Nitzan Lubianiker , Tamar Koren , Neomi Singer , Tamar Ben Shannan , Shai Shen Orr , Fahed Hakim , Hilla Azulay-Debby , Rani Cohen
Abstract: The present invention is directed to a method for inducing an immune response in a subject, including a step of activating neurons in the mesolimbic network of the subject by applying a neurofeedback.
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Patent Agency Ranking
公开(公告)号：US12165070B2
公开(公告)日：2024-12-10
申请号：US16626824
申请日：2018-06-27
Inventor： Ramez Daniel , Loai Danial
Abstract: An analog signal processing circuit comprising: a first promoter operably linked to a nucleic acid sequence encoding a first output molecule, wherein said promoter is responsive to a cooperative input signal comprising at least two cooperative inputs, and wherein expression of said at least two cooperative inputs is tunable.
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7.发明公开公开(公告)号：US20240325437A1
公开(公告)日：2024-10-03
申请号：US18619343
申请日：2024-03-28
Inventor： Noga RON-HAREL , David EZUZ
CPC classification number: A61K33/26 , A61K31/49 , A61K38/385 , A61K39/39 , A61P37/04
Abstract: A method of increasing proliferation of adaptive immune cells of a subject at least 65 years old is provided. The method comprising contacting the immune cells with an agent which increases the level of labile iron in the immune cells and/or reduces toxicity of hemoglobin, heme or a degradation product thereof, thereby increasing the proliferation of the adaptive immune cells of the subject.
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公开(公告)号：US12084523B2
公开(公告)日：2024-09-10
申请号：US17982883
申请日：2022-11-08
Inventor： Ashraf Brik , Mickal Nawatha , Hiroaki Suga , Joseph Rogers
Abstract: The present invention is directed to a cyclic polypeptide having ubiquitin binding affinity (KD) of 0.1-100 nM. Further provided are methods for reducing deubiquitination activity of a cell, and for treating cancer in a subject in need thereof.
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公开(公告)号：US20240269318A1
公开(公告)日：2024-08-15
申请号：US18626620
申请日：2024-04-04
Inventor： Avi SCHROEDER , Mor SELA
CPC classification number: A61K47/6911 , A61P25/16 , B82Y5/00
Abstract: In one aspect of the invention, there is provided a nanoparticle comprising a core and a shell, wherein the core comprises a bioactive compound, and the shell comprises a lipid layer comprising a first modified lipid and a additional lipid, wherein the first modified lipid is bound to a targeted moiety via a spacer, and wherein the additional lipid comprises a polymer-bound lipid. The present invention further provides pharmaceutical compositions and methods for therapeutic and/or diagnostic use.
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公开(公告)号：US12060575B2
公开(公告)日：2024-08-13
申请号：US17178279
申请日：2021-02-18
Inventor： Michal Amit , Joseph Itskovitz-Eldor
IPC: C12N5/0735 , C12N5/00
CPC classification number: C12N5/0606 , C12N5/0031 , C12N5/0037 , C12N5/0043 , C12N2501/115 , C12N2501/15 , C12N2501/2306 , C12N2501/235 , C12N2533/12 , C12N2533/90
Abstract: A method of expanding and maintaining human embryonic stem cells (ESCs) in an undifferentiated state by culturing the ESCs in a suspension culture under culturing conditions devoid of substrate adherence is provided. Also provided are a method of deriving ESC lines in the suspension culture and methods of generating lineage-specific cells from ESCs which were expanded in the suspension culture of the present invention.
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