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公开(公告)号：US20220028416A1
公开(公告)日：2022-01-27
申请号：US17297695
申请日：2019-11-28
发明人： Jacob COHEN , Joseph KESHET , Alma COHEN
摘要： A system comprising at least one hardware processor and a non-transitory computer-readable storage medium having stored thereon program instructions, the program instructions executable by the at least one hardware processor to: receive a voice recording comprising a phonation by a subject, analyze said voice recording to calculate a fundamental frequency contour curve of said phonation, measure at least one of (i) a time period from a start of said phonation until said contour curve reaches a settled level, (ii) a slope of said contour curve during said time period, and (iii) an area under said contour curve during said time period, and determine a glottal closure insufficiency in said subject based, at least in part, on said measuring.
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公开(公告)号：US20210052777A1
公开(公告)日：2021-02-25
申请号：US16967237
申请日：2019-02-04
申请人： TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED , B. G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD., AT BEN-GURION UNIVERSITY , RAMBAM MED-TECH LTD.
摘要： The present invention is directed to, inter alia, a scaffold-cell construct including a biocompatible polymer (e.g., poly-l-lactic acid (PLLA) and polylactic glycolic acid (PLGA)) and recombinant cells having increased GLUT4 levels and/or activity. The invention is further directed to methods for reducing glucose levels in a subject in need thereof. Also provided are methods of producing the scaffold-cell construct of the invention.
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公开(公告)号：US10561707B2
公开(公告)日：2020-02-18
申请号：US15413991
申请日：2017-01-24
发明人： Shira Toledano , Ofra Kessler , Gera Neufeld , Yoreh Barak , Yelena Mumblat
摘要： The present invention relates, according to some embodiments, method of treating eye diseases, such as AMD by administering Semaphorin 3C (Sema3C) or a variant thereof having amino acid modifications at furin-like pro-protein convertase cleavage sites, rendering these sites resistant to cleavage.
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公开(公告)号：US20190309368A1
公开(公告)日：2019-10-10
申请号：US16449585
申请日：2019-06-24
申请人： Walter Gabriel WASSER , Technion Research & Development Foundation Limited , Ramot at Tel-Aviv University Ltd. , Rambam Med-Tech Ltd.
发明人： Karl SKORECKI , Shay TZUR , Saharon ROSSET , Walter Gabriel WASSER , Doron M. BEHAR , Revital SHEMER
IPC分类号： C12Q1/6883 , C12Q1/70 , G01N33/68
摘要： Provided are methods and kits for determining predisposition of a subject to develop a kidney disease, by identifying in a sample of the subject at least one APOL1 polypeptide variant which is characterized by a higher trypanolytic activity on Trypanosoma brucei rhodesiense as compared to the trypanolytic activity of wild type APOL1 polypeptide as set forth in SEQ ID NO:1 on the Trypanosoma brucei rhodesiense under identical assay conditions; or at least one APOL1 nucleotide mutation in the APLO1 genomic sequence set forth in SEQ ID NO:3, wherein the at least one nucleotide mutation or polypeptide variant being in linkage disequlibrium (LD) with the S342G mutation in the APOL1 polypeptide set forth in SEQ ID NO:1, wherein presence of the APOL1 polypeptide variant indicates increased predisposition of the subject to develop the kidney disease.
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公开(公告)号：US20170354453A1
公开(公告)日：2017-12-14
申请号：US15527499
申请日：2015-11-19
发明人： Yakov Krasik , Joshua Felsteiner , Yakov Slutsker , Ziv Gil , Jacob Cohen , Yoav Binen-Baum
CPC分类号： A61B18/042 , A61B1/018 , A61B2017/00039 , A61B2017/00057 , A61B2017/00061 , A61B2018/00791 , A61B2018/00982 , H05H1/2406 , H05H2001/245 , H05H2001/2456 , H05H2001/2462 , H05H2245/122
摘要： A system for generating cold plasma is presented, suitable for use in in-vivo treatment of biological tissue. The system comprising: a control unit connectable to an elongated member at a first proximal end of the elongated member. The elongated member comprises a plasma generating unit at a second distal end thereof and gas and electricity transmission channels extending from said first proximal end towards said plasma generating unit. The control unit comprises a gas supply unit configured to provide predetermined flow rate of selected gas composition through said gas transmission channel and a power supply unit configured to generate selected sequence of high-frequency electrical pulses, typically in mega Hertz range, directed through said electricity transmission channel, thereby providing power and gas of said selected composition to the plasma generating unit for generating cold plasma.
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公开(公告)号：US20170312388A1
公开(公告)日：2017-11-02
申请号：US15516805
申请日：2015-10-07
申请人： Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. , Rambam Med-Tech Ltd.
发明人： Oded SHOSEYOV , Danny PORATH , Ofra BENNY , Yaron BAR-LAVIE , Amos OFER
摘要： The invention disclosed herein generally provides implantable medical devices and implants that may be removed on-demand from a subject's body at any time after their implanting in the body, without necessitating invasive procedures.
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公开(公告)号：US20240199703A1
公开(公告)日：2024-06-20
申请号：US18287276
申请日：2022-04-18
申请人： RAMBAM MED-TECH LTD.
发明人： Yona NADIR
CPC分类号： C07K14/001 , A61L15/32 , A61P7/04 , C07K4/00 , A61K38/00
摘要： There is provided procoagulant peptides, and use of same, such as in treatment of hemostasis-related diseases or disorders, and/or wound healing.
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公开(公告)号：US20240117438A1
公开(公告)日：2024-04-11
申请号：US18538027
申请日：2023-12-13
发明人： Shai SHEN-ORR , Yehuda CHOWERS , Shiran GERASSY-VAINBERG , Alexandra BLATT , Elina STAROVETSKY , Renaud Gilles GAUJOUX , Naama MAIMON
IPC分类号： C12Q1/6883 , C07K16/24 , G01N33/564
CPC分类号： C12Q1/6883 , C07K16/241 , G01N33/564 , C12Q2600/106 , C12Q2600/158 , G01N2800/52
摘要： The present invention is directed to a kit and a method for determining the suitability of a subject to a treatment using a tumor necrosis factor alpha (TNFα). Further provided is a method for treating the subject determined to be suitable for a treatment using a TNFα inhibitor.
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9.发明公开公开(公告)号：US20240018592A1
公开(公告)日：2024-01-18
申请号：US18033582
申请日：2021-10-26
IPC分类号： C12Q1/6883 , C12Q1/6837
CPC分类号： C12Q1/6883 , C12Q1/6837 , C12Q2600/158 , C12Q2600/106
摘要： A method of analyzing the therapeutic efficacy of a therapeutic agent for treating an immune-related disorder is disclosed. The method comprises contacting blood cells of the subject with the agent, measuring the expression of at least 20 genes in the blood cells of the subject; obtaining an immune age value based on the expression of the at least 20 genes, and comparing the immune age value with an immune age value of the subject calculated on the basis of expression of the at least 20 genes in blood cells of the subject, in the absence of the agent.
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公开(公告)号：US11740225B2
公开(公告)日：2023-08-29
申请号：US15972671
申请日：2018-05-07
发明人： Iyad Khamaysi , Eyal Zussman
IPC分类号： G01N33/487 , G01N33/574 , A61B10/04 , A61B17/34 , G01N11/14
CPC分类号： G01N33/487 , A61B10/04 , A61B17/3403 , G01N33/57438 , A61B2010/045 , A61B2017/3413 , G01N11/14 , G01N2203/0089 , G01N2333/705 , G01N2333/928
摘要： The present invention provides methods for determining malignancy in a cyst by measuring viscosity of cyst fluid while under stain. The invention further provides devices, and computer program products for determining same.
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