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公开(公告)号:US20210059936A1
公开(公告)日:2021-03-04
申请号:US16963648
申请日:2019-01-23
Inventor: Avi SCHROEDER , Assaf ZINGER
IPC: A61K9/127 , A61P35/00 , A61K38/48 , A61K31/337
Abstract: Pharmaceutical compositions comprising at least one lipid-based particle encapsulating a proteolytic enzyme and a pharmaceutically acceptable carrier, wherein the proteolytic enzyme comprises at least 75% proteolytically active enzyme are provided. Methods of using same and producing same are also provided.
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公开(公告)号:US20240269318A1
公开(公告)日:2024-08-15
申请号:US18626620
申请日:2024-04-04
Inventor: Avi SCHROEDER , Mor SELA
CPC classification number: A61K47/6911 , A61P25/16 , B82Y5/00
Abstract: In one aspect of the invention, there is provided a nanoparticle comprising a core and a shell, wherein the core comprises a bioactive compound, and the shell comprises a lipid layer comprising a first modified lipid and a additional lipid, wherein the first modified lipid is bound to a targeted moiety via a spacer, and wherein the additional lipid comprises a polymer-bound lipid. The present invention further provides pharmaceutical compositions and methods for therapeutic and/or diagnostic use.
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公开(公告)号:US20240090512A1
公开(公告)日:2024-03-21
申请号:US18273357
申请日:2022-01-20
Applicant: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. , TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED
Inventor: Oded SHOSEYOV , Avi SCHROEDER , Aviram AVITAL , Noy SADOT MUZIKA , Zohar Lily PERSKY
Abstract: The present invention provides a nanoparticle including: (a) an amphiphilic co-polymer including an ionizable polymer covalently bound to a hydrophobic domain; and a polynucleotide comprising 60 to 500 nucleobases. Further provided are compositions including the nanoparticle of the invention, and methods of using same.
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公开(公告)号:US20190224111A1
公开(公告)日:2019-07-25
申请号:US16311861
申请日:2017-06-21
Inventor: Havazelet BIANCO-PELED , Avi SCHROEDER , Shlomit AVIDAN-SHLOMOVICH , Yarden DEGANI , Mor GOLDFEDER
IPC: A61K9/00 , A61K9/06 , A61K47/36 , A61K9/127 , A61K31/704 , A61K31/513 , A61K39/395 , A61K33/243
Abstract: A composition and method for the administration of therapeutic and/or diagnostic agents is provided. Specifically, a hybrid system, composed of polymer that harbors drug-loaded lipid nanoparticles, and use thereof for the administration of active agents e.g., anti-cancer agents, is provided.
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公开(公告)号:US20240091145A1
公开(公告)日:2024-03-21
申请号:US18527308
申请日:2023-12-03
Applicant: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED , Health Corporation Of Tzafon Medical Center (R.A.)
Inventor: Havazelet BIANCO-PELED , Avi SCHROEDER , Imad ABU EL-NAAJ , Layan HABIB , Mohammed ALYAN , Yasmin GHANTOUS
Abstract: A composition and method for the administration of therapeutic and/or diagnostic agents is provided. Specifically, a dry hybrid system, composed of bio adhesive polymer that harbors drug-loaded lipid nanoparticles, and use thereof for the administration of active agents e.g., anti-cancer agents or biological agents, is provided.
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公开(公告)号:US20250057985A1
公开(公告)日:2025-02-20
申请号:US18933233
申请日:2024-10-31
Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD. , TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED
Inventor: Ayelet EREZ , Omer GOLDMAN , Emma HAJAJ , Avi SCHROEDER
Abstract: Methods of predicting clinical outcome in a subject suffering from cancer, detecting non-liver cancer in a subject, and methods of treating or preventing cancer or cancer-associated cachexia are provided. Synthetic lipid nanoparticles encapsulating an mRNA encoding for HNF4A and composition comprising same are also provided.
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公开(公告)号:US20210040568A1
公开(公告)日:2021-02-11
申请号:US17079959
申请日:2020-10-26
Inventor: Avi SCHROEDER , Zvi YAARI
IPC: C12Q1/6886 , A61K49/00
Abstract: A theranostic composition and method for determining the cell-specific potency of drugs is provided. Further, compositions and methods useful for studying the therapeutic profile of one or more drugs within a cell microenvironment, including but not limited to a tumor, are provided.