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    STABLE, DURABLE GRANULES WITH ACTIVE AGENTS
    2.
    发明申请
    STABLE, DURABLE GRANULES WITH ACTIVE AGENTS 审中-公开
    稳定的，具有活性剂的耐用颗粒

    公开(公告)号：US20150030679A1

    公开(公告)日：2015-01-29

    申请号：US14338588

    申请日：2014-07-23

    Applicant: Danisco US Inc.

    Inventor： Nathaniel T. BECKER ,  Kathleen A. CLARKSON ,  Douglas A. DALE ,  Beth FRYKSDALE ,  Mark S. GEBERT ,  Troels N. GRAVESEN ,  Michael PARTSUF

    IPC: A61K9/14 ,  A61K38/46 ,  A61K47/02 ,  A61K38/47 ,  A23K1/165 ,  A23K1/18

    CPC classification number: A61K9/14 ,  A23K20/189 ,  A23K40/30 ,  A23K50/75 ,  A61K9/16 ,  A61K9/5073 ,  A61K38/465 ,  A61K38/47 ,  A61K47/02 ,  C12N9/96 ,  C12N9/98

    Abstract: A stable, durable granule for feed compositions has a core, at least one active agent; and at least one coating. The active agent of the granule retains at least 50% activity, at least 60% activity, at least 70% activity, at least 80% activity after conditions selected from one or more of a) a feed pelleting process, b) a steam-heated feed pretreatment process, c) storage, d) storage as an ingredient in an unpelleted mixture, and e) storage as an ingredient in a feed base mix or a feed premix comprising at least one compound selected from trace minerals, organic acids, reducing sugars, vitamins, choline chloride, and compounds which result in an acidic or a basic feed base mix or feed premix.

    Abstract translation: 用于饲料组合物的稳定，耐用的颗粒具有核心，至少一种活性剂; 和至少一个涂层。 颗粒的活性剂在选自a）进料造粒方法中的一种或多种的条件之后保留至少50％的活性，至少60％的活性，至少70％的活性，至少80％的活性，b） 加热进料预处理方法，c）储存，d）作为未混和的混合物中的成分进行储存，以及e）作为原料的混合物或原料预混物中的成分储存，所述进料预混物包含至少一种选自微量矿物质，有机酸，还原剂 糖，维生素，氯化胆碱和导致酸性或碱性饲料基料混合物或饲料预混物的化合物。

    Method for preparing an enzyme containing granule
    4.
    发明授权
    Method for preparing an enzyme containing granule 有权
    制备含有颗粒的酶的方法

    公开(公告)号：US07273736B2

    公开(公告)日：2007-09-25

    申请号：US10777335

    申请日：2004-02-11

    Applicant: Poul Bach

    Inventor： Poul Bach

    IPC: C12N9/98 ,  C12N11/04 ,  C12N9/96 ,  A21D2/00 ,  C11D7/42

    CPC classification number: C11D3/38672 ,  A21D8/042 ,  A23K20/189 ,  C12N9/00 ,  C12N9/98

    Abstract: The invention relates processes for producing enzyme containing granules having an enzyme containing core and a shell coating the core wherein the preparation of the core and application of the shell are independent and are physically separated by time and/or location.

    Abstract translation: 本发明涉及用于生产含酶核的颗粒的方法和包覆核的外壳，其中核的制备和外壳的应用是独立的并且通过时间和/或位置物理分离。

    Enzyme granulate
    5.
    发明授权
    Enzyme granulate 有权
    酶颗粒

    公开(公告)号：US06933141B1

    公开(公告)日：2005-08-23

    申请号：US09675952

    申请日：2000-09-29

    Applicant: Poul Bach

    Inventor： Poul Bach

    IPC: A21D8/04 ,  A23K1/165 ,  C11D3/386 ,  C12N9/00 ,  C12N9/98

    CPC classification number: C11D3/38672 ,  A21D8/042 ,  A23K20/189 ,  C12N9/00 ,  C12N9/98

    Abstract: The invention relates to an enzyme-containing granule comprising a core unit and a shell unit, wherein the core unit comprises the enzyme and is enclosed in a shell unit which is substantially enzyme-free, the ratio between the diameter of the granule and the diameter of the core unit being at least 1.1. Also processes for producing such granules and use of the granules are disclosed.

    Abstract translation: 本发明涉及含有核心单元和壳单元的含酶颗粒，其中核心单元包含酶，并且被包封在基本上无酶的壳单元中，颗粒直径与直径之比 的核心单位至少为1.1。 还公开了生产这种颗粒和使用颗粒的方法。

    Process for the production of enzyme granules
    7.
    发明申请
    Process for the production of enzyme granules 审中-公开
    酶颗粒生产工艺

    公开(公告)号：US20030124224A1

    公开(公告)日：2003-07-03

    申请号：US10275515

    申请日：2002-11-04

    Inventor： Rudolf Carolus Maria Barendse ,  Gabriel Marinus Henricus Meesters ,  Antonius Johannes Maria Happel

    IPC: A23K001/00

    CPC classification number: C12N9/98

    Abstract: The invention describes a process for the continuous production of enzyme granules characterised in that:(h) a liquid enzyme preparation containing one or more enzymes is produced(i) optionally additives are added to the liquid enzyme preparation obtained in (a)(j) one or more liquid enzyme preparations obtained in (a) or (b) are sprayed into a fluidised bed by means of spray nozzles(k) fine material that escapes from the fluid bed with the off-gas is separated off and returned to the fluidised bed as nuclei for the granule formation(l) granules of a predetermined size are formed by adjusting the sifting gas stream(m) the finished granules are discharged via one or more countercurrent gravity sifters installed in the inflow plate of the fluidised bed apparatus(n) optionally the enzyme granules obtained in step (f) are coated. The invention further provides enzyme granules characterised by an isotropic structure, a spherical shape and smooth surface as expressed by a roundness factor between 1 and 1.6 and optionally a coating.

    Abstract translation: 本发明描述了连续生产酶颗粒的方法，其特征在于：（h）含有一种或多种酶的液体酶制剂（i）任选地将添加剂加入到（a）（j）中获得的液体酶制剂中， （a）或（b）中获得的一种或多种液体酶制剂通过喷嘴（k）从流化床逸出的细料喷射到流化床中，废气被分离并返回到流化床 床作为颗粒形成的核（l）通过调节筛分气体流（m）形成预定尺寸的颗粒，成品颗粒经由安装在流化床装置（n）的流入板中的一个或多个逆流重力筛分器排出 ）任选地涂布步骤（f）中获得的酶颗粒。 本发明进一步提供了由圆形度因子介于1和1.6之间的各向同性结构，球形和光滑表面的酶颗粒，以及任选的涂层。

    Enzyme particles
    8.
    发明授权
    Enzyme particles 失效

    公开(公告)号：US06544763B2

    公开(公告)日：2003-04-08

    申请号：US09984895

    申请日：2001-10-31

    Applicant: Yoshinobu Imaizumi ,  Koichi Ohori ,  Itsuro Tsukahara ,  Hiroyuki Yamashita

    Inventor： Yoshinobu Imaizumi ,  Koichi Ohori ,  Itsuro Tsukahara ,  Hiroyuki Yamashita

    IPC: C12N998

    CPC classification number: C11D3/38672 ,  C11D3/40 ,  C12N9/98

    Abstract: Enzyme granules are provided in which an enzyme is rapidly eluted, without insoluble remnants, and generation of powdery dust is suppressed, and which granules have a property such that classification phenomenon generated among the granules in a detergent composition is less likely to take place, in a case where the enzyme granules are formulated together with other components in a detergent. The enzyme granule comprise (A) water-insoluble substance and or a slightly water-soluble substance; (B) a water-soluble binder; and (C) an enzyme. A dye may also be present for coloring. The content of (A) component is 45% by weight or more, and the enzyme granules have an average particle size of from 150 to 500 &mgr;m and a bulk density of from 500 to 1,000 g/L, and have a structure such that more amount of (B) component is present near the surface of the enzyme granules than in the inner portion thereof. The enzyme granule may be aggregated to form an enzyme granule aggregate. A process is provided for preparing the enzyme granule by spray-drying a slurry containing (A), (B) and (C). The enzyme granule aggregate may be prepared by adding an aqueous binding solution to the granules and drying, or by adding molten thermoplastic binder to the granules and cooling.

    Carbohydrate-based enzyme-containing granules for use in animal feed
    9.
    发明授权
    Carbohydrate-based enzyme-containing granules for use in animal feed 失效
    用于动物饲料的基于碳水化合物的含酶颗粒

    公开(公告)号：US06500426B1

    公开(公告)日：2002-12-31

    申请号：US09090528

    申请日：1998-06-04

    Applicant: Rudolf Carolus Maria Barendse ,  Gabriel Marinus Henricus Meesters ,  Hans-Peter Harz

    Inventor： Rudolf Carolus Maria Barendse ,  Gabriel Marinus Henricus Meesters ,  Hans-Peter Harz

    IPC: A61K3843

    CPC classification number: C12N15/80 ,  A23K10/14 ,  A23K20/158 ,  A23K20/163 ,  A23K20/189 ,  A23K40/10 ,  A23K40/20 ,  A23K40/25 ,  A23K50/10 ,  A23K50/40 ,  A23K50/75 ,  A23K50/80 ,  C12N9/16 ,  C12N9/98 ,  C12Y301/03008 ,  C12Y302/01004 ,  C12Y302/01008 ,  Y02A40/818 ,  Y10S426/805 ,  Y10S426/807

    Abstract: Enzyme-containing granules for manufacturing animal feed compositions are prepared using a carrier containing at least about 15% (w/w) carbohydrate such as starch and less than 5% (w/w) protein. A mixture is formed containing an enzyme, the carrier and water, with or without prior kneading to improve plasticity, the mixture is mechanically processed such as by extrusion with a basket or dome extruder while not allowing the temperature of the mixture to rise above about 40° C., and drying the resultant enzyme-containing granules. The granules may be spheronised prior to drying, and drying may be in a fluid bed agglomerator. The water and enzyme may be provided as an enzyme-containing aqueous liquid such as an enzyme-containing filtrate from a fermentation process. Enzymes include phytase, endo-xylanase and &bgr;-glucanase. Other components that may be in the granules include divalent cations, cellulose, polyvinyl alcohol and an edible oil. Animal feed compositions may be prepared by mixing the granules with feed ingredients, sterilizing or treating with steam, and pelleting. The compositions show improved enzyme stability during pelleting.

    Abstract translation: 用于制备动物饲料组合物的含酶颗粒使用含有至少约15％（w / w）碳水化合物如淀粉和小于5％（w / w）蛋白质的载体制备。 形成含有酶，载体和水的混合物，在或不进行先前的捏合以改善可塑性的情况下，将混合物机械加工，例如通过用篮子或圆顶挤出机挤出，同时不允许混合物的温度升高到大约40℃ 并干燥得到的含酶颗粒。 颗粒可以在干燥之前被球形化，并且干燥可以在流化床聚结器中。 可以从发酵过程中提供水和酶作为含酶的含水液体，例如含酶滤液。 酶包括植酸酶，内切木聚糖酶和β-葡聚糖酶。 可以在颗粒中的其它组分包括二价阳离子，纤维素，聚乙烯醇和食用油。 动物饲料组合物可以通过将颗粒与饲料成分混合，用蒸汽灭菌或处理和造粒来制备。 组合物在造粒期间显示改善的酶稳定性。

    Matrix granule
    10.
    发明申请
    Matrix granule 有权
    基质颗粒

    公开(公告)号：US20020192775A1

    公开(公告)日：2002-12-19

    申请号：US10180785

    申请日：2002-06-25

    Inventor： Nathaniel T. Becker ,  Thomas S. Green

    IPC: C12N011/08

    CPC classification number: C12N9/98 ,  Y10S530/812 ,  Y10S530/813

    Abstract: Granules that include a protein core are described. The protein core includes a protein matrix which includes a protein mixed together with a starch. The protein matrix can be layered over a seed particle or the protein core can be homogeneous. The protein can be an enzyme or a therapeutic protein.

    Abstract translation: 描述了包含蛋白质核心的颗粒。 蛋白质核心包括蛋白质基质，其包括与淀粉混合在一起的蛋白质。 蛋白质基质可以分层在种子颗粒上，或蛋白质核心可以是均质的。 蛋白质可以是酶或治疗性蛋白质。

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