公开(公告)号：US20250042955A1

公开(公告)日：2025-02-06

申请号：US18807406

申请日：2024-08-16

Applicant: DANISCO US INC.

Inventor： Daniel Joseph Macool ,  Paula Johanna Maria Teunissen ,  Yehong Jamie Wang ,  Hyeryoung Yoon ,  Quinn Qun Zhu

IPC: C07K14/395 ,  C12N15/81

Abstract: Described are compositions and methods relating to the over-expression of sugar transporter-like polypeptides to reduce the amount of glycerol and acetate produced by modified yeast having an exogenous pathway that cause it to produce more ethanol and acetate than its parental yeast.

公开(公告)号：US20250002925A1

公开(公告)日：2025-01-02

申请号：US18710129

申请日：2022-11-11

Applicant: DANISCO US INC.

Inventor： Zhen Ma ,  Ryan Frisch ,  Brian Paul ,  Steven Doig ,  Stacey Robida-Stubbs

IPC: C12N15/75 ,  C12N1/20 ,  C12N9/26 ,  C12P21/02 ,  C12R1/10

Abstract: Certain embodiments of the disclosure are related to recombinant Bacillus strains comprising enhanced protein productivity phenotypes, compositions and methods for constructing such recombinant Bacillus cells, and the like. The recombinant Bacillus strains described herein are particularly useful for the enhanced production of proteins of interest when grown/cultivated/fermented under suitable conditions.

公开(公告)号：US20240409965A1

公开(公告)日：2024-12-12

申请号：US18704733

申请日：2022-11-04

Applicant: DANISCO US INC.

Inventor： Hans Marinus Charles Johannes DE BRUIJN ,  Evert Tjeerd VAN RIJ ,  Mickel Leonardus August JANSEN ,  Marco Richard VAN DER WEERT ,  Wouter KROES ,  Johannes Gustaaf Ernst VAN LEEUWEN

IPC: C12P7/06 ,  C12N1/18 ,  C12N9/34 ,  C12R1/865

Abstract: A variant polypeptide of a parent polypeptide, wherein the parent polypeptide comprises the amino acid sequence of SEQ ID NO: 1, and wherein the variant polypeptide comprises an amino acid sequence which, when aligned with the amino acid sequence of SEQ ID NO: 1, comprises an amino acid substitution of V202I, A203N, V333S, Y335M and/or D336G, the positions of said amino acids being defined with reference to the amino acid sequence of SEQ ID NO: 1. A recombinant yeast cell functionally expressing a nucleotide encoding the variant polypeptide and a process for the production of ethanol using the variant polypeptide and/or recombinant yeast.

公开(公告)号：US20240384205A1

公开(公告)日：2024-11-21

申请号：US18687521

申请日：2022-09-01

Applicant: Danisco US Inc.

Inventor： Jonathan Lassila ,  Zhenghong Zhang ,  Kun Zhong

IPC: C11D3/386 ,  C12N9/22

Abstract: Disclosed herein are compositions and methods for preventing, reducing, or removing biofilms.

公开(公告)号：US12146173B2

公开(公告)日：2024-11-19

申请号：US17854595

申请日：2022-06-30

Applicant: DANISCO US INC

Inventor： Marc Kolkman ,  Anja Hemmingsen Kellett-Smith ,  Rie Mejldal ,  Lilia Maria Babe

IPC: C12N9/54 ,  C11D3/386

Abstract: The present disclosure relates to serine proteases and variants thereof. Compositions containing the serine proteases are suitable for use in cleaning fabrics and hard surfaces, as well as in a variety of industrial applications.

公开(公告)号：US20240376457A1

公开(公告)日：2024-11-14

申请号：US18437009

申请日：2024-02-08

Applicant: Danisco US Inc.

Inventor： William Cuevas ,  Vivek Sharma ,  David E. Wildes ,  Sang-Kyu Lee ,  Dina Finan

IPC: C12N9/28 ,  C11D3/386 ,  C12N9/26 ,  C12P19/14

Abstract: Disclosed are compositions and methods relating to variant alpha-amylases. The variant alpha-amylases are useful, for example, for starch liquefaction and saccharification, for cleaning starchy stains in laundry, dishwashing, and other applications, for textile processing (e.g., desizing), in animal feed for improving digestibility, and for baking and brewing.

公开(公告)号：US12043853B2

公开(公告)日：2024-07-23

申请号：US17376669

申请日：2021-07-15

Applicant: DANISCO US INC

Inventor： Andrew Shaw ,  David A Estell ,  Eugene S Sadlowski ,  Hiroshi Oh ,  Louise Wallace ,  Ronaldus Wilhelmus Joannes Hommes ,  Sang-Kyu Lee

IPC: C12N9/54 ,  C11D1/02 ,  C11D3/386

CPC classification number: C12N9/54 ,  C11D1/02 ,  C11D3/386 ,  C11D3/38663 ,  C12Y304/24

Abstract: The present invention provides methods and compositions comprising at least one neutral metalloprotease enzyme that has improved storage stability. In some embodiments, the neutral metalloprotease finds use in cleaning and other applications. In some particularly preferred embodiments, the present invention provides methods and compositions comprising neutral metalloprotease(s) obtained from Bacillus sp. In some more particularly preferred embodiments, the neutral metalloprotease is obtained from B. amyloliquefaciens. In still further preferred embodiments, the neutral metalloprotease is a variant of the B. amyloliquefaciens neutral metalloprotease. In yet additional embodiments, the neutral metalloprotease is a homolog of the the B. amyloliquefaciens neutral metalloprotease. The present invention finds particular use in applications including, but not limited to cleaning, bleaching and disinfecting.

公开(公告)号：US12012604B2

公开(公告)日：2024-06-18

申请号：US17347204

申请日：2021-06-14

Applicant: DANISCO US INC.

Inventor： Paul Klaassen ,  Jozef Petrus Johannes Schmitz ,  Paulus Petrus De Waal ,  Arjen Bouma

IPC: C12N15/81 ,  C12N9/00 ,  C12N9/02 ,  C12N9/04 ,  C12N9/12 ,  C12N9/16 ,  C12N9/92 ,  C12P7/06 ,  C12P7/10

CPC classification number: C12N15/81 ,  C12N9/0006 ,  C12N9/0008 ,  C12N9/1205 ,  C12N9/16 ,  C12N9/92 ,  C12N9/93 ,  C12P7/06 ,  C12P7/10 ,  C12Y102/0101 ,  C12Y207/01028 ,  C12Y207/01029 ,  C12Y301/03021 ,  C12Y503/01005 ,  C12Y602/01001 ,  C12P2203/00 ,  Y02E50/10

Abstract: The present invention relates to a yeast cell that is genetically modified comprising:



a) a disruption of one or more aldehyde dehydrogenase (E.C:1.2.1.4) native to the yeast;
b) one or more nucleotide sequence encoding a heterologous NAD+-dependent acetylating acetaldehyde dehydrogenase (E.C. 1.2.1.10);
c) one or more nucleotide sequence encoding a homologous or heterologous acetyl-CoA synthetase (E.C. 6.2.1.1); and
d) a modification that leads to reduction of glycerol 3-phosphate phosphohydrolase (E.C. 3.1.3.21) and/or glycerol 3-phosphate dehydrogenase (E.C. 1.1.1.8 or E.C. 1.1.5.3) activity, native to the yeast.

公开(公告)号：US11946078B2

公开(公告)日：2024-04-02

申请号：US17237235

申请日：2021-04-22

Applicant: DANISCO US INC

Inventor： Neeraj Pandey ,  Sina Pricelius ,  Annapurna Sachan ,  Stepan Shipovskov ,  Richard Bott ,  Ajit Kumar Satapathy

IPC: C12N9/24 ,  C11D3/386 ,  C12N9/42 ,  C12N15/63

CPC classification number: C12N9/2437 ,  C11D3/38645 ,  C12N9/24 ,  C12N15/63 ,  C12Y302/01004

Abstract: Disclosed herein are cellulase variants, or active fragments thereof, and polynucleotides encoding same, where the cellulase variants, or active fragments thereof, have endoglucanase activity. Also disclosed herein are compositions comprising the cellulase variants, or active fragments thereof; vectors and/or host cells comprising the polynucleotides encoding the cellulase variants, or active fragments thereof; and methods for making and/or using the cellulase variants, or active fragments thereof and/or compositions containing same; where the cellulase variants, or active fragments thereof, have endoglucanase activity.

公开(公告)号：US20230365947A1

公开(公告)日：2023-11-16

申请号：US18044250

申请日：2021-09-16

Applicant: Danisco US Inc.

Inventor： FENG GUO ,  HELONG HAO ,  BRADLEY KELEMEN ,  AMY DEMING LIU ,  KEFENG NI ,  ZHEN QIAN ,  ZHONGMEI TANG

IPC: C12N9/18 ,  C08J11/10

CPC classification number: C12N9/18 ,  C08J11/105 ,  C08J2367/02 ,  C08J2301/32

Abstract: The present disclosure relates to a method and a composition comprising an esterase for enzymatic surface modification of a polyester. The present disclosure also relates to a method of degradation or hydrolysis of an insoluble plant material.