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公开(公告)号：US20240082327A1
公开(公告)日：2024-03-14
申请号：US18456354
申请日：2023-08-25
发明人： Deborah R. GILL , Stephen C. HYDE
CPC分类号： A61K35/76 , C12N7/02 , C12N9/22 , C12N9/24 , C12N9/6427 , C12N15/86 , C12N2760/18822 , C12N2760/18832 , C12N2760/18843 , C12N2760/18851 , C12Y302/01018
摘要： The present invention relates to retroviral vectors, particularly lentiviral vectors, comprising a modified retroviral RNA sequence that is codon-substituted and comprises a reduced number of retroviral open-reading frames, and wherein the retroviral vector is pseudotyped with hemagglutinin-neuraminidase (HN) and fusion (F) proteins from a respiratory paramyxovirus, methods of making the same and uses thereof.
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2.发明申请公开(公告)号：US20190194667A1
公开(公告)日：2019-06-27
申请号：US16213729
申请日：2018-12-07
申请人： Eun Kyung Do , MODNBIO, INC.
发明人： Jong Cheon Hahm , Eun Kyung Do
CPC分类号： C12N15/52 , C12N9/24 , C12N9/2445 , C12N15/63 , C12N15/74 , C12P33/00 , C12P33/20 , C12Y302/01021
摘要： The present invention relates to a method of producing ginsenoside 20(S)—Rg3 or 20(S)—Rh2 using a novel ginsenoside glycosidase in order to obtain ginsenoside 20(S)—Rg3 or 20(S)—Rh2 with high efficiency and high purity. According to the production method of the present invention, a large amount of 20(S)—Rg3 or 20(S)—Rh2, which is a minor form of rare ginsenoside present in very small amounts in ginseng or processed ginseng products, may be safely and efficiently produced. In particular, the method according to the present invention has an advantag5e in that it may produce a large amount of 20(S)—Rg3 or 20(S)—Rh2 for industrial applications, since the process is very simple and the production efficiency is very high.
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3.发明申请公开(公告)号：US20180265590A1
公开(公告)日：2018-09-20
申请号：US15982141
申请日：2018-05-17
申请人： Academia Sinica
发明人： Chi-Huey WONG , Chung-Yi WU , Che MA , Han-Chung WU
CPC分类号： C07K16/30 , A61K45/06 , C07K16/1018 , C07K16/18 , C07K16/241 , C07K16/2887 , C07K16/32 , C07K2317/21 , C07K2317/24 , C07K2317/41 , C07K2317/52 , C07K2317/622 , C07K2317/732 , C07K2317/734 , C07K2319/00 , C12N9/24 , C12P21/005 , C12Y302/01 , C12Y302/01051
摘要： The present disclosure relates to compositions and methods of use comprising antibodies or binding fragments thereof further comprising universal Fc glycoforms.
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公开(公告)号：US20180223292A1
公开(公告)日：2018-08-09
申请号：US15749224
申请日：2016-07-27
申请人： Kao Corporation
CPC分类号： C12N15/80 , C07K14/37 , C12N9/0006 , C12N9/1085 , C12N9/24 , C12N15/09 , C12P1/02 , C12P7/44
摘要： Provided is a promoter suitable for the high expression of a gene of interest. A promoter consisting of a DNA selected from the group consisting of the following (a) to (d): (a) a DNA comprising the nucleotide sequence represented by any one of SEQ ID NOs: 1 to 3; (b) a DNA consisting of a nucleotide sequence having at least 70% identity to the nucleotide sequence represented by any one of SEQ ID NOs: 1 to 3 and having a promoter activity; (c) a DNA consisting of a nucleotide sequence wherein one or several of nucleotides are deleted, substituted or added in the nucleotide sequence represented by any one of SEQ ID NOS: 1 to 3 and having a promoter activity; and (d) a DNA which hybridizes with a DNA consisting of a nucleotide sequence complementary to the nucleotide sequence represented by any one of SEQ ID NOs: 1 to 3 under stringent conditions and which has a promoter activity.
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公开(公告)号：US09982247B2
公开(公告)日：2018-05-29
申请号：US14415254
申请日：2013-07-18
CPC分类号： C12N9/24 , C07K16/36 , C07K2317/22 , C07K2317/569 , C12N9/6437 , C12Y304/21021
摘要： An anti-Factor VII affinity ligand that is particularly useful for purifying recombinant human activated Factor VII from transgenic sources. The affinity ligand combined with other orthogonal chromatographic steps allows the preparation of a highly purified FVII solution fully activated free of aggregates with a low percentage of degraded or oxidized FVII forms.
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公开(公告)号：US20180030492A1
公开(公告)日：2018-02-01
申请号：US15788482
申请日：2017-10-19
发明人： Philippe J. Dufresne , Adam H. Colville , Barbara Fryzuk , Loreta Gudynaite-Savitch , Christopher M.D. Hindle , Boguslaw Ploch , John J. Tomashek
IPC分类号： C12P19/14 , C12P19/00 , C12N9/42 , C12N9/24 , C12N9/14 , C12N1/14 , C07K14/38 , C12P19/02 , C07K14/37
CPC分类号： C12P19/14 , C07K14/37 , C07K14/38 , C12N1/14 , C12N9/14 , C12N9/24 , C12N9/2437 , C12P19/00 , C12P19/02
摘要： The present invention provides an isolated fungal cell that is capable of producing one or more biomass-degrading enzymes and that exhibits increased or decreased expression or copy number of a polynucleotide encoding a PtaB-like protein. Also provided is a fermentation processes for producing one or more biomass-degrading enzymes comprising a fungal cells exhibiting increased or decreased expression or copy number of a polynucleotide encoding a PtaB-like protein. The biomass-degrading enzymes produced by the isolate fungal cell and fermentation processes of the present invention may be used in a process to produce soluble sugars from biomass.
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公开(公告)号：US09687532B2
公开(公告)日：2017-06-27
申请号：US15251701
申请日：2016-08-30
CPC分类号： A61K38/47 , A61K9/0019 , A61K45/06 , C12N9/24 , C12N9/2402 , C12N9/2468 , C12Y302/01031
摘要： The present application relates to sialylated glycoprotein compositions and methods of their use in treating various conditions and disorders.
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公开(公告)号：US20170175099A1
公开(公告)日：2017-06-22
申请号：US15381039
申请日：2016-12-15
CPC分类号： C12N11/10 , C07K2319/23 , C12N9/24 , C12P19/00 , C12P19/04 , C12P19/26 , C12P21/005 , C12Y302/02 , C12Y305/01052
摘要： N-glycosylation profiling of glycoprotein biotherapeutics is an essential step in each phase of product development in the biopharmaceutical industry. For example, during clone selection hundreds of clones should be analyzed quickly from limited amounts of samples. On the other hand, identification of disease related glycosylation alterations can serve as early indicators for various pathological conditions in the biomedical field. We describe an improved packed bed column PNGase F functionalized column reactor. The reactor may be packed into a pipette tip column. In some embodiments, a second column or mixed stationary phase may be packed into the column to capture and purify the cleaved glycan prior to analysis. Complete N-glycan removal can be obtained in 10 minutes from all major N-linked glycoprotein types. The approach can be readily applied to automated sample preparation systems, such as liquid handling robots.
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公开(公告)号：US09605250B2
公开(公告)日：2017-03-28
申请号：US14111531
申请日：2012-04-12
IPC分类号： A61K38/43 , C12N9/24 , C12N9/36 , C12N1/06 , C12N15/62 , C07K14/47 , C12N9/48 , C07K14/005 , A61K38/00
CPC分类号： C12N9/2462 , A61K38/00 , C07K14/005 , C07K14/47 , C07K14/4742 , C07K2319/03 , C12N1/06 , C12N9/24 , C12N9/48 , C12N15/62 , C12N2795/00022 , C12N2795/00033 , C12N2795/10122 , C12N2795/10133 , C12N2795/10322 , C12N2795/10333 , C12Y302/01017 , Y02A50/475 , Y02A50/483
摘要： Provided herein are antibacterial compositions and methods of making and using the compositions.
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公开(公告)号：US09567563B2
公开(公告)日：2017-02-14
申请号：US15014585
申请日：2016-02-03
CPC分类号： C12N1/14 , C07K14/38 , C12N9/24 , C12N9/2437 , C12N9/485 , C12N9/62 , C12Y302/01091
摘要： Provided are an Aspergillus mutant strain which can dramatically enhance production of a heterologous enzyme when a saccharifying enzyme gene is transferred into the strain to perform transformation and a transformant having a saccharifying enzyme gene transferred into the Aspergillus mutant strain. The Aspergillus mutant strain has been completely or partially deficient in three genes of Aspergillus oryzae strain HO2 (accession number: NITE BP-01750): a prtR gene coding for a transcription factor; a pepA gene coding for an extracellular acid protease; and a cpI gene coding for an extracellular acid carboxypeptidase.
摘要翻译： 提供了当将糖化酶基因转移到菌株进行转化时，可以显着提高异源酶的产生的曲霉菌突变菌株和将糖化酶基因转移到曲霉菌突变株中的转化体。 曲霉菌突变菌株在米曲霉菌株HO2（登录号：NITE BP-01750）的三个基因中完全或部分缺陷：编码转录因子的prtR基因; 编码细胞外酸性蛋白酶的pepA基因; 和编码细胞外酸羧肽酶的cpI基因。
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