公开(公告)号：US12129273B2

公开(公告)日：2024-10-29

申请号：US18227782

申请日：2023-07-28

申请人： Academia Sinica

发明人： Chih-Cheng Chen ,  Jim-Min Fang ,  Cheng-Han Lee ,  Jen-Yao Chang

IPC分类号： C07H19/16 ,  A61K31/7076 ,  A61K38/04 ,  A61K47/55 ,  A61P29/00

CPC分类号： C07H19/16 ,  A61K31/7076 ,  A61K38/046 ,  A61K47/55 ,  A61P29/00

摘要： Compounds for use in prevention and/or treatment of pain are disclosed. The compounds are derived by conjugation of N6-(4-hydroxybenzyl)adenosine and analogous compounds with amino acids or peptides. In one embodiment of the invention, the compound is 5′-glycylcarbonyl-N6-(4-hydroxybenzyl)adenosine (I-a1). In another embodiment of the invention, the compound is 5′-deoxy-5′-(N′-glycylureido)-N6-(4-hydroxybenzyl)adenosine (I-d1). Also disclosed are methods of making and using the same.

公开(公告)号：US20240347203A1

公开(公告)日：2024-10-17

申请号：US18299051

申请日：2023-04-12

申请人： Taipei Veterans General Hospital ,  Academia Sinica ,  National Taiwan University

发明人： Hao-Min Cheng ,  Yeong-Sung Lin ,  Yennun Huang ,  Chiu-Han Hsiao ,  Po-Chun Yu ,  Chia-Ying Hsieh ,  Wei-Lun Chang

IPC分类号： G16H50/30 ,  G16B20/00

CPC分类号： G16H50/30 ,  G16B20/00

摘要： Methods and computer-implemented methods are used to predict a risk of cardiovascular disease by using a machine learning mode to analyze a relationship between the occurrence of cardiovascular disease and the health data of patients.

公开(公告)号：US20240219704A1

公开(公告)日：2024-07-04

申请号：US18608479

申请日：2024-03-18

申请人： Academia Sinica

发明人： Jung-Chi LIAO ,  Yi-De CHEN ,  Chih-Wei CHANG ,  Weng Man CHONG

IPC分类号： G02B21/36 ,  G02B21/06 ,  G02B21/26 ,  G06V10/141 ,  G06V10/25 ,  G06V20/69 ,  H04N23/56 ,  H04N23/74

CPC分类号： G02B21/365 ,  G02B21/06 ,  G02B21/26 ,  G06V10/141 ,  G06V10/25 ,  G06V20/693 ,  H04N23/56 ,  H04N23/74

摘要： A system and method for image-guided microscopic illumination are provided. A processing module controls an imaging assembly such that a camera acquires an image or images of a sample in multiple fields of view, and the image or images are automatically transmitted to a processing module and processed by the first processing module automatically in real-time based on a predefined criterion so as to determine coordinate information of an interested region in each field of view. The processing module also controls an illuminating assembly to illuminate the interested region of the sample according to the received coordinate information regarding to the interested region, with the illumination patterns changing among the fields of view.

公开(公告)号：US20240196931A1

公开(公告)日：2024-06-20

申请号：US18286943

申请日：2022-04-14

申请人： ACADEMIA SINICA

发明人： Lie-Fen SHYUR ,  Yu-Chuan LIANG ,  Wen-Yuh LIN ,  Chin-Ting CHANG ,  Meng-Ting CHANG ,  Yu-Hsin CHEN

IPC分类号： A23K10/30 ,  A23K50/30 ,  A61K36/28 ,  A61P31/14

CPC分类号： A23K10/30 ,  A23K50/30 ,  A61K36/28 ,  A61P31/14

摘要： Provided is an animal feed composition including a plant-based feed additive. Also provided is a method for promoting overall health condition of an animal, including increase of feed efficiency and decrease of feed converting rate, increase of probiotics and decrease of pathogens in gut microbiota of pigs, anti-inflammation, affecting primary metabolism, promoting growth and survival rate, and preventing or treating diseases caused by pathogenic bacteria, porcine reproductive and respiratory syndrome virus (PRRSV).

公开(公告)号：US20240180845A1

公开(公告)日：2024-06-06

申请号：US18533542

申请日：2023-12-08

申请人： Academia Sinica

发明人： Che-Ming Jack Hu ,  Hui-Wen Chen ,  Bing-Yu Yao

IPC分类号： A61K9/51 ,  A61K31/708 ,  B82Y5/00 ,  C12N15/113 ,  C12N15/87

CPC分类号： A61K9/5153 ,  A61K9/5192 ,  A61K31/708 ,  C12N15/113 ,  C12N15/87 ,  B82Y5/00

摘要： A polymeric nanoparticle that has a size of 30-600 nm in outer diameter and contains a polymeric shell, less than 25 nm in thickness and impermeable to water, one or more aqueous cores enclosed by the polymeric shell, and a bioactive agent encapsulated in each of the one or more aqueous cores. Also disclosed are a method of preparing the polymeric nanoparticle and a method of using it for treating a disease.

公开(公告)号：US11992525B2

公开(公告)日：2024-05-28

申请号：US18501578

申请日：2023-11-03

申请人： ACADEMIA SINICA

发明人： Chi-Huey Wong ,  Hsin-Yu Liao ,  Shih-Chi Wang ,  Yi-An Ko ,  Kuo-I Lin ,  Che Ma ,  Ting-Jen Cheng

IPC分类号： A61K39/00 ,  A61K39/12 ,  A61K39/145 ,  A61P31/16 ,  C07K14/005

CPC分类号： A61K39/145 ,  A61P31/16 ,  C07K14/005 ,  A61K2039/575

摘要： The present disclosure relates to a chimeric influenza virus hemagglutinin (HA) polypeptide, comprising one or more stem domain sequence, each having at least 60% homology with a stem domain consensus sequence of H1 subtype HA (H1 HA) and/or H5 subtype HA (H5 HA), fused with one or more globular head domain sequence, each having at least 60% homology with a globular head domain consensus sequence of H1 subtype HA (H1 HA) or H5 subtype HA (H5 HA).

公开(公告)号：US20240124528A1

公开(公告)日：2024-04-18

申请号：US18266882

申请日：2021-12-14

申请人： Academia Sinica

发明人： Wen-Hwa LEE ,  Heng-Hsiung WU ,  Chun-Mei HU ,  Chun-Kai HUANG

IPC分类号： C07K14/00 ,  A61P35/00 ,  G01N33/574 ,  G01N33/68

CPC分类号： C07K14/001 ,  A61P35/00 ,  G01N33/57488 ,  G01N33/6869 ,  A61K38/00

摘要： The present invention relates to an antagonist of interleukin-17B receptor (IL-17RB) which features interruption of the interaction of IL-17RB and MLK4. The present invention also relates to use of such antagonist for treatment of diseases or disorders associated with IL-17RB activation. Further disclosed is a phosphorylated IL-17RB as a biomarker for predicting prognosis and/or monitoring progression of cancer.

公开(公告)号：US11918000B2

公开(公告)日：2024-03-05

申请号：US16432230

申请日：2019-06-05

申请人： Academia Sinica

发明人： Hsin-Hung Yeh ,  Yi-Shu Chiu

IPC分类号： A01N63/30 ,  A01N63/32 ,  C08B37/00 ,  C12N1/14 ,  C12N1/16 ,  C12R1/645

CPC分类号： A01N63/30 ,  A01N63/32 ,  C08B37/0087 ,  C12N1/145 ,  C12N1/165 ,  C12R2001/645

摘要： The present disclosure relates to fungi, a culture filtrate thereof and a polysaccharide and their applications in inducing or priming plant resistance to viruses. Aspects of the present disclosure provides a cultured filtrate, derived from a fungus belonging to the genus Trichosporon, induces strong resistance to various viruses on different plants.

公开(公告)号：US20240066113A1

公开(公告)日：2024-02-29

申请号：US18029758

申请日：2022-04-12

申请人： ACADEMIA SINICA

发明人： Chi-Huey WONG ,  Chung-Yi WU ,  Che MA ,  Chen-Yu FAN

IPC分类号： A61K39/215 ,  A61K9/127 ,  A61P31/14 ,  C07K14/165

CPC分类号： A61K39/215 ,  A61K9/127 ,  A61P31/14 ,  C07K14/165 ,  A61K2039/545

摘要： The present invention relates to the mRNA vaccine of coronavirus spike protein with deletion of glycosites in the receptor binding domain (RBD), the subunit 1 (S1) domain, or the subunit 2 (S2) domain, or a combination thereof. The vaccine elicits broadly protective immune responses coronavirus and variants thereof.

公开(公告)号：US11866485B2

公开(公告)日：2024-01-09

申请号：US17937744

申请日：2022-10-03

申请人： ACADEMIA SINICA

发明人： Kuo-I Lin ,  Che Ma ,  Chi-Huey Wong ,  Szu-Wen Wang ,  Yi-Hsuan Chang ,  Xiaorui Chen ,  Han-Yi Huang

IPC分类号： C07K16/10 ,  A61K39/42 ,  A61K39/00

CPC分类号： C07K16/10 ,  A61K39/42 ,  A61K2039/505 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/41 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

摘要： The present disclosure relates to an antibody or antigen-binding fragment thereof that specifically binds to a spike protein of SARS-CoV-2. The present disclosure also relates to a pharmaceutical composition, a method for treating and/or preventing diseases and/or disorders caused by a coronavirus in a subject in need thereof, and a method for detecting a coronavirus in a sample.