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公开(公告)号：US09539196B2
公开(公告)日：2017-01-10
申请号：US14949967
申请日：2015-11-24
申请人： ELC Management LLC
发明人： Nadine Pernodet , Kelly Dong , Edward Pelle
CPC分类号： A61K8/64 , A61K8/66 , A61K8/99 , A61Q17/04 , A61Q19/08 , C12Y302/02 , C12Y305/01 , C12Y402/99018
摘要： Compositions of the invention comprise 8-oxoguanine glycosylase (OGG1) and SIRT6 activating peptide G-A-G-V-S-A-E-NH2. Compositions of the invention exhibit anti-aging effects by promoting the repair of skin cell DNA and/or by protecting skin cell DNA from UV damage.
摘要翻译： 本发明的组合物包含8-氧基鸟嘌呤糖基化酶（OGG1）和SIRT6活化肽G-A-G-V-S-A-E-NH 2。 本发明的组合物通过促进皮肤细胞DNA的修复和/或通过保护皮肤细胞DNA免受紫外线损伤而显示抗衰老作用。
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公开(公告)号：US20170175099A1
公开(公告)日：2017-06-22
申请号：US15381039
申请日：2016-12-15
CPC分类号： C12N11/10 , C07K2319/23 , C12N9/24 , C12P19/00 , C12P19/04 , C12P19/26 , C12P21/005 , C12Y302/02 , C12Y305/01052
摘要： N-glycosylation profiling of glycoprotein biotherapeutics is an essential step in each phase of product development in the biopharmaceutical industry. For example, during clone selection hundreds of clones should be analyzed quickly from limited amounts of samples. On the other hand, identification of disease related glycosylation alterations can serve as early indicators for various pathological conditions in the biomedical field. We describe an improved packed bed column PNGase F functionalized column reactor. The reactor may be packed into a pipette tip column. In some embodiments, a second column or mixed stationary phase may be packed into the column to capture and purify the cleaved glycan prior to analysis. Complete N-glycan removal can be obtained in 10 minutes from all major N-linked glycoprotein types. The approach can be readily applied to automated sample preparation systems, such as liquid handling robots.
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3.发明申请Compositions Comprising A Sirt6 Activator As A Component Of A Yeast Ferment Extract And A DNA Repair Enzyme 审中-公开包含Sirt6活化剂作为酵母发酵提取物和DNA修复酶的组分的组合物公开(公告)号：US20170071845A1
公开(公告)日：2017-03-16
申请号：US15365109
申请日：2016-11-30
申请人： ELC Management LLC
发明人： Nadine Pernodet , Kelly Dong , Edward Pelle
CPC分类号： A61K8/64 , A61K8/66 , A61K8/99 , A61Q17/04 , A61Q19/08 , C12Y302/02 , C12Y305/01 , C12Y402/99018
摘要： Compositions of the invention comprise 8-oxoguanine glycosylase (OGG1) and SIRT6 activating peptide G-A-G-V-S-A-E-NH2. Compositions of the invention exhibit anti-aging effects by promoting the repair of skin cell DNA and/or by protecting skin cell DNA from UV damage.
摘要翻译： 本发明的组合物包含8-氧基鸟嘌呤糖基化酶（OGG1）和SIRT6活化肽G-A-G-V-S-A-E-NH 2。 本发明的组合物通过促进皮肤细胞DNA的修复和/或通过保护皮肤细胞DNA免受紫外线损伤而显示抗衰老作用。
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4.发明申请公开(公告)号：US20160158139A1
公开(公告)日：2016-06-09
申请号：US14949967
申请日：2015-11-24
申请人： ELC Management LLC
发明人： Nadine Pernodet , Kelly Dong , Edward Pelle
CPC分类号： A61K8/64 , A61K8/66 , A61K8/99 , A61Q17/04 , A61Q19/08 , C12Y302/02 , C12Y305/01 , C12Y402/99018
摘要： Compositions of the invention comprise 8-oxoguanine glycosylase (OGG1) and SIRT6 activating peptide G-A-G-V-S-A-E-NH2. Compositions of the invention exhibit anti-aging effects by promoting the repair of skin cell DNA and/or by protecting skin cell DNA from UV damage.
摘要翻译： 本发明的组合物包含8-氧基鸟嘌呤糖基化酶（OGG1）和SIRT6活化肽G-A-G-V-S-A-E-NH 2。 本发明的组合物通过促进皮肤细胞DNA的修复和/或通过保护皮肤细胞DNA免受紫外线损伤而显示抗衰老作用。
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