公开(公告)号：US11806431B2

公开(公告)日：2023-11-07

申请号：US17337306

申请日：2021-06-02

申请人： Velico Medical Inc.

发明人： Qiyong Peter Liu ,  Junqing Cui ,  Rud Karly Lucien ,  Ryan Carney ,  Jihae Sohn ,  Michelle Arya ,  Abdul W. Khan

IPC分类号： A61K9/16 ,  F26B3/06 ,  F26B3/12 ,  F26B5/04 ,  A61K35/16 ,  B01J19/06 ,  F26B3/04 ,  F26B5/06 ,  B65D81/26 ,  B65D51/30

CPC分类号： A61K9/1682 ,  A61K9/16 ,  A61K9/1617 ,  A61K9/1688 ,  A61K35/16 ,  B01J19/06 ,  F26B3/04 ,  F26B3/06 ,  F26B3/12 ,  F26B5/04 ,  B01J2219/00177 ,  B65D51/30 ,  B65D81/266 ,  F26B5/065

摘要： A method of treatment of plasma with a physiologically compatible spray dry stable acidic substance (SDSAS) prior to or contemporaneously with spray drying of the plasma that results in greater recovery and greater long-term stabilization of the dried plasma proteins as compared to spray dried plasma that has not be subject to the formulation method of the present invention, as well as compositions related to plasma dried by the methods of the present invention.

公开(公告)号：US20230168034A1

公开(公告)日：2023-06-01

申请号：US17996985

申请日：2021-04-30

申请人： ULVAC, INC.

发明人： Sora UEMATSU ,  Hiromu MATSUBAYASHI ,  Tsutomu NISHIHASHI ,  Masaki ITOU ,  Tsuyoshi YOSHIMOTO ,  Susumu ARAI ,  Nobuhiro MOTEGI

IPC分类号： F26B5/06

CPC分类号： F26B5/065 ,  A23L3/44

摘要： [Object] To freeze droplets of a raw material liquid in a shorter drop distance while maintaining a cooling velocity, which is a super high speed, without deteriorating a solute or dispersoid.
[Solving Means] A vacuum freeze-drying method according to an embodiment of the present invention is a vacuum freeze-drying method that includes steps of injecting a raw material liquid from an injection nozzle inside a vacuum chamber, generating frozen particles by self-freezing of the raw material liquid, and drying the generated frozen particles to thereby produce a dry powder, including: injecting the raw material liquid from the injection nozzle in a state in which the vacuum chamber is maintained at water vapor partial pressure corresponding to a self-freezing temperature of the raw material liquid, such that an injection initial velocity of the raw material liquid from the injection nozzle is 6 m/s or more and 33 m/s or less; and adjusting, when the maximum diameter of the generated frozen particle exceeds a predetermined value or droplets of the raw material liquid are unfrozen, an injection flow rate of the raw material liquid from the injection nozzle or properties of the injection nozzle such that frozen particles having a maximum diameter equal to or smaller than the predetermined value are generated.

公开(公告)号：US09920989B2

公开(公告)日：2018-03-20

申请号：US14348877

申请日：2012-10-04

申请人： Sanofi Pasteur SA

发明人： Bernhard Luy ,  Matthias Plitzko ,  Manfred Struschka

IPC分类号： F26B5/06

CPC分类号： F26B5/06 ,  F26B5/065

摘要： A process line (300) for the production of freeze-dried particles under closed conditions comprising at least a spray chamber (302) for droplet generation and freeze congealing of the liquid droplets to form particles and a bulk freeze-dryer (304) for freeze drying the particles, the freeze-dryer (304) comprising a rotary drum for receiving the particles. Further, a transfer section (308) is provided for a product transfer from the spray chamber (302) to the freeze-dryer (304). For the production of the particles under end-to-end closed conditions each of the devices (302, 304) and of the transfer section (308) is separately adapted for operation preserving sterility of the product to be freeze-dried and/or containment.

公开(公告)号：US20160082043A1

公开(公告)日：2016-03-24

申请号：US14670127

申请日：2015-03-26

申请人： Velico Medical, Inc.

发明人： Abdul Wahid Khan ,  Michael Wilt ,  Rud Karly Lucien ,  Jihae Sohn ,  Qiyong Peter Liu

IPC分类号： A61K35/16 ,  F26B3/06 ,  A61J1/10

CPC分类号： A61K9/1682 ,  A61K9/16 ,  A61K9/1617 ,  A61K9/1688 ,  A61K35/16 ,  B01J19/06 ,  B01J2219/00177 ,  B65D51/30 ,  B65D81/266 ,  F26B3/04 ,  F26B3/06 ,  F26B3/12 ,  F26B5/04 ,  F26B5/065

摘要： Disclosed are methods of spray drying blood plasma using a two-step drying process.

摘要翻译： 公开了使用两步干燥方法喷雾干燥血浆的方法。

公开(公告)号：US20150307692A1

公开(公告)日：2015-10-29

申请号：US14686050

申请日：2015-04-14

申请人： THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY

发明人： Musa KAMAL ,  Vahid KHOSHKAVA

IPC分类号： C08K7/26 ,  F26B5/06 ,  C08B15/02 ,  C08L1/04 ,  C08L23/12

CPC分类号： F26B5/06 ,  C08B15/02 ,  C08K7/26 ,  C08K9/08 ,  C08L1/04 ,  F26B5/065 ,  C08L23/12

摘要： The present disclosure relates to a process for reducing particle agglomeration and/or increasing porosity of agglomerated particles, a method for enhancing dispersion of nanoparticles in a polymer matrix, and thermoplastic or thermoset nanocomposites comprising nanoparticles.

摘要翻译： 本公开内容涉及减少颗粒团聚和/或增加附聚颗粒的孔隙率的方法，用于增强纳米颗粒在聚合物基质中的分散性的方法，以及包含纳米颗粒的热塑性或热固性纳米复合材料。

公开(公告)号：US08459046B2

公开(公告)日：2013-06-11

申请号：US12945812

申请日：2010-11-12

申请人： Martin Richter-Friis ,  Signe Andersen Kolmos

发明人： Martin Richter-Friis ,  Signe Andersen Kolmos

IPC分类号： B01J2/02 ,  A61K39/36 ,  A61K39/35 ,  A61K9/16 ,  A61J1/00 ,  F16K17/00

CPC分类号： B01J2/06 ,  A61J1/00 ,  A61K9/1688 ,  F26B5/065

摘要： The present invention relates to processes for the preparation of a batch of an active pharmaceutical ingredient, e.g. an allergen product. The invention also relates to a container comprising cryogranules of a liquid composition of an allergen product, and to a cryogranule of an allergen product. The processes feature formation of cryogranules using a container having therein a cryogenic medium (e.g. liquid nitrogen) and storage of the cryogranules in the same container. The cryogranules obtained can be stored and handled without prior freeze-drying.

公开(公告)号：US20110104216A1

公开(公告)日：2011-05-05

申请号：US12945814

申请日：2010-11-12

申请人： Martin RICHTER-FRIIS ,  Signe Kolmos

发明人： Martin RICHTER-FRIIS ,  Signe Kolmos

IPC分类号： A61K39/35 ,  A61K9/00 ,  A61K39/36 ,  A61P37/08

CPC分类号： B01J2/06 ,  A61J1/00 ,  A61K9/1688 ,  F26B5/065

摘要： The present invention relates to processes for the preparation of a batch of an active pharmaceutical ingredient, e.g. an allergen product. The invention also relates to a container comprising cryogranules of a liquid composition of an allergen product, and to a cryogranule of an allergen product. The processes feature formation of cryogranules using a container having therein a cryogenic medium (e.g. liquid nitrogen) and storage of the cryogranules in the same container. The cryogranules obtained can be stored and handled without prior freeze-drying.

摘要翻译： 本发明涉及制备一批活性药物成分的方法，例如， 过敏原产品。 本发明还涉及包含变应原产物的液体组合物的低温颗粒和变应原产物的低温颗粒的容器。 该方法的特征是使用其中具有低温介质（例如液氮）的容器并将低温颗粒储存在同一容器中来形成低温颗粒。 获得的低温颗粒可以储存和处理，而无需预先冷冻干燥。

公开(公告)号：US20110016742A1

公开(公告)日：2011-01-27

申请号：US12445797

申请日：2007-10-16

申请人： Steve Anderson ,  James Kenneth Carson ,  John Cuddon ,  Steven Planthaber

发明人： Steve Anderson ,  James Kenneth Carson ,  John Cuddon ,  Steven Planthaber

IPC分类号： F26B5/06

CPC分类号： F26B5/065 ,  A23L3/44 ,  B01D1/18 ,  B01J2/26

摘要： The invention relates to a spray freeze dryer apparatus and method of using same for use in drying or concentrating a raw material which at ambient conditions has a solid and an aqueous portion. The dryer includes a chamber and a chamber pressure reduction device; an inlet nozzle or nozzles through which the raw material is injected into the chamber; and a collection surface or surfaces which collect a frozen portion of the raw material. The chamber is kept at a pressure below the triple-point pressure of the aqueous portion of the raw material. Several additional features are described to control the thickness of the layer on the collection surface.

摘要翻译： 本发明涉及一种喷雾冷冻干燥装置及其使用方法，用于干燥或浓缩在环境条件下具有固体和水性部分的原料。 干燥机包括室和室减压装置; 入口喷嘴或喷嘴，原料通过喷嘴或喷嘴注入到腔室中; 以及收集原料的冷冻部分的收集表面。 该室被保持在低于原料的水性部分的三点压力的压力。 描述了几个附加特征来控制收集表面上的层的厚度。

公开(公告)号：US20080257021A1

公开(公告)日：2008-10-23

申请号：US12097788

申请日：2006-12-15

申请人： Holger Gruell ,  Hendrik Roelof Stapert

发明人： Holger Gruell ,  Hendrik Roelof Stapert

IPC分类号： G01N1/00 ,  B05D3/02

CPC分类号： A61K9/1676 ,  A61K9/1682 ,  A61K49/0002 ,  A61K49/1818 ,  A61K49/1851 ,  B82Y5/00 ,  F26B5/065

摘要： A method is provided that prepares resuspendable particles of a compound. The particles are prepared by drying a liquid that comprises the compound. The particles are dried in such a way that they do not aggregate on redispersion. The particles that are thus obtained are especially suitable for use in bio sensors, as contrast agent or as part of a pharmaceutical composition.

摘要翻译： 提供了制备化合物的可重悬的颗粒的方法。 通过干燥包含该化合物的液体来制备颗粒。 颗粒以这样的方式干燥，使得它们在再分散时不聚集。 由此获得的颗粒特别适用于生物传感器，造影剂或作为药物组合物的一部分。

公开(公告)号：US20080155853A1

公开(公告)日：2008-07-03

申请号：US12050654

申请日：2008-03-18

申请人： Zhaolin Wang ,  Warren H. Finlay

发明人： Zhaolin Wang ,  Warren H. Finlay

IPC分类号： F26B5/00 ,  F26B5/06

CPC分类号： B01J2/04 ,  A61K9/1623 ,  A61K9/1682 ,  F26B5/065 ,  Y10T436/25

摘要： A method of manufacturing heat-sensitive pharmaceutical powder is disclosed. The original pharmaceutical substances are dissolved in a solution or suspended in a suspension, which is sprayed through an atomizing nozzle and frozen in a cold gas phase or liquid nitrogen atomized directly in the spray-freeze chamber or gas jacket at the same time (for cooling purposes). The particles are freeze-dried at roughly atmospheric pressure in a down-stream fluid flow with exit filter thereby to remove moisture entrapped on or inside the frozen particles. The system has applicability for forming other powders.

摘要翻译： 公开了一种制造热敏药用粉末的方法。 将原始药物溶解在悬浮液中，悬浮在悬浮液中，该悬浮液通过雾化喷嘴喷雾并在冷气相或液氮中在冷冻室或气套中同时雾化（用于冷却 目的）。 颗粒在大气压下在具有出口过滤器的下游流体流中冷冻干燥，从而除去截留在冷冻颗粒上或内部的水分。 该系统适用于形成其他粉末。