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公开(公告)号：US12024701B2
公开(公告)日：2024-07-02
申请号：US17465133
申请日：2021-09-02
发明人： Christopher C. Langenfeld , David D. B. Cannan , Dirk A. van der Merwe , Dean Kamen , Jason A. Demers , Frederick Morgan , Timothy D. Moreau , Brian D. Tracey , Matthew Ware , Richard J. Lanigan , Michael A. Baker , David Blumberg, Jr. , Richard E. Gautney , Derek G. Kane , Dane Fawkes , Thomas J. Bollenbach , Michael C. Tilley , Stuart A. Jacobson , John F. Mannisto
IPC分类号： C12M3/00 , A01N1/02 , A61L27/38 , B33Y10/00 , B33Y30/00 , B33Y70/00 , C12M1/00 , C12M1/12 , C12M1/26 , C12M1/34 , C12M1/36 , C12N1/00 , C12N5/00
CPC分类号： C12M41/48 , A01N1/0247 , A61L27/3895 , B33Y10/00 , B33Y30/00 , B33Y70/00 , C12M21/08 , C12M23/22 , C12M23/38 , C12M25/02 , C12M27/18 , C12M29/00 , C12M33/00 , C12M37/02 , C12M41/12 , C12M41/40 , C12M41/46 , C12N5/0018 , C12N5/0062 , C12N2533/00 , C12N2533/50 , C12N2533/90
摘要： A system and method for growing and maintaining biological material including producing a protein associated with the tissue, selecting cells associated with the tissue, expanding the cells, creating at least one tissue bio-ink including the expanded cells, printing the at least one tissue bio-ink in at least one tissue growth medium mixture, growing the tissue from the printed at least one tissue bio-ink, and maintaining viability of the tissue.
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公开(公告)号：US20210009936A1
公开(公告)日：2021-01-14
申请号：US17028435
申请日：2020-09-22
发明人： Dean Kamen , Jason A. Demers , Frederick Morgan , Timothy D. Moreau , Brian D. Tracey , Matthew Ware , Dirk A. van der Merwe , Richard J. Lanigan , Michael A. Baker , David Blumberg, JR.
摘要： A fluid pumping and bioreactor system including at least two cassettes, at least one storage reservoir, at least one bioreactor, at least one manifold including valve modules, and tubing to connect the cassettes to the storage reservoir and the bioreactor. The cassettes can include pumps, valves, and fluid conduits and can be communicatively connected to the at least one manifold. The bioreactor can include an adapter and fluid conduits extending through the adapter from the exterior of the bioreactor to the interior of the bioreactor. System and method for generating a tissue for transplant by decellularizing and recellularizing a supplied tissue.
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公开(公告)号：US10808218B2
公开(公告)日：2020-10-20
申请号：US16360330
申请日：2019-03-21
发明人： Dean Kamen , Jason A. Demers , Frederick Morgan , Timothy D. Moreau , Brian D. Tracey , Matthew Ware , Dirk A. van der Merwe , Richard J. Lanigan , Michael A. Baker , David Blumberg, Jr.
摘要： A fluid pumping and bioreactor system including at least two cassettes, at least one storage reservoir, at least one bioreactor, at least one manifold including valve modules, and tubing to connect the cassettes to the storage reservoir and the bioreactor. The cassettes can include pumps, valves, and fluid conduits and can be communicatively connected to the at least one manifold. The bioreactor can include an adapter and fluid conduits extending through the adapter from the exterior of the bioreactor to the interior of the bioreactor. System and method for generating a tissue for transplant by decellularizing and recellularizing a supplied tissue.
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公开(公告)号：US20240344016A1
公开(公告)日：2024-10-17
申请号：US18749741
申请日：2024-06-21
发明人： Christopher C. Langenfeld , David D. B. Cannan , Dirk A. Van Der Merwe , Dean Kamen , Jason A. Demers , Frederick Morgan , Timothy D. Moreau , Brian D. Tracey , Matthew Ware , Richard J. Lanigan , Michael A. Baker , David Blumberg, JR. , Richard E. Andrews , Derek G. Kane , Dane C. Fawkes , Thomas J. Bollenbach , Michael C. Tilley , Stuart A. Jacobson , John F. Mannisto
IPC分类号： C12M1/36 , A01N1/02 , A61L27/38 , B33Y10/00 , B33Y30/00 , B33Y70/00 , C12M1/00 , C12M1/12 , C12M1/26 , C12M1/34 , C12M3/00 , C12N5/00
CPC分类号： C12M41/48 , A01N1/0247 , A61L27/3895 , B33Y10/00 , B33Y30/00 , B33Y70/00 , C12M21/08 , C12M23/22 , C12M23/38 , C12M25/02 , C12M27/18 , C12M29/00 , C12M33/00 , C12M37/02 , C12M41/12 , C12M41/40 , C12M41/46 , C12N5/0018 , C12N5/0062 , C12N2533/00 , C12N2533/50 , C12N2533/90
摘要： A system and method for growing and maintaining biological material including producing a protein associated with the tissue, selecting cells associated with the tissue, expanding the cells, creating at least one tissue bio-ink including the expanded cells, printing the at least one tissue bio-ink in at least one tissue growth medium mixture, growing the tissue from the printed at least one tissue bio-ink, and maintaining viability of the tissue.
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公开(公告)号：US11939566B2
公开(公告)日：2024-03-26
申请号：US17465153
申请日：2021-09-02
发明人： Christopher C. Langenfeld , David D. B. Cannan , Dirk A. van der Merwe , Dean Kamen , Jason A. Demers , Frederick Morgan , Timothy D. Moreau , Brian D. Tracey , Matthew Ware , Richard J. Lanigan , Michael A. Baker , David Blumberg, Jr. , Richard E. Gautney , Derek G. Kane , Dane Fawkes , Thomas J. Bollenbach , Michael C. Tilley , Stuart A. Jacobson , John F. Mannisto
IPC分类号： C12M3/00 , A01N1/02 , A61L27/38 , B01L3/00 , B33Y10/00 , B33Y30/00 , B33Y70/00 , C12M1/00 , C12M1/12 , C12M1/26 , C12M1/34 , C12M1/36 , C12N5/00
CPC分类号： C12M41/48 , A01N1/0247 , A61L27/3895 , B33Y10/00 , B33Y30/00 , B33Y70/00 , C12M21/08 , C12M23/22 , C12M23/38 , C12M25/02 , C12M27/18 , C12M29/00 , C12M33/00 , C12M37/02 , C12M41/12 , C12M41/40 , C12M41/46 , C12N5/0018 , C12N5/0062 , C12N2533/00 , C12N2533/50 , C12N2533/90
摘要： A system and method for growing and maintaining biological material including producing a protein associated with the tissue, selecting cells associated with the tissue, expanding the cells, creating at least one tissue bio-ink including the expanded cells, printing the at least one tissue bio-ink in at least one tissue growth medium mixture, growing the tissue from the printed at least one tissue bio-ink, and maintaining viability of the tissue.
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公开(公告)号：US20210395672A1
公开(公告)日：2021-12-23
申请号：US17465162
申请日：2021-09-02
发明人： Christopher C. Langenfeld , David D. B. Cannan , Dirk A. van der Merwe , Dean Kamen , Jason A. Demers , Frederick Morgan , Timothy D. Moreau , Brian D. Tracey , Matthew Ware , Richard J. Lanigan , Michael A. Baker , David Blumberg, JR. , Richard E. Gautney , Derek G. Kane , Dane Fawkes , Thomas J. Bollenbach , Michael C. Tilley , Stuart A. Jacobson , John F. Mannisto
IPC分类号： C12M1/36 , C12M3/00 , C12M1/34 , C12M1/00 , C12M1/12 , C12N5/00 , C12M1/26 , A61L27/38 , B33Y10/00 , B33Y30/00 , B33Y70/00 , A01N1/02
摘要： A system and method for growing and maintaining biological material including producing a protein associated with the tissue, selecting cells associated with the tissue, expanding the cells, creating at least one tissue bio-ink including the expanded cells, printing the at least one tissue bio-ink in at least one tissue growth medium mixture, growing the tissue from the printed at least one tissue bio-ink, and maintaining viability of the tissue.
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公开(公告)号：US20210395671A1
公开(公告)日：2021-12-23
申请号：US17465153
申请日：2021-09-02
发明人： Christopher C. Langenfeld , David D. B. Cannan , Dirk A. van der Merwe , Dean Kamen , Jason A. Demers , Frederick Morgan , Timothy D. Moreau , Brian D. Tracey , Matthew Ware , Richard J. Lanigan , Michael A. Baker , David Blumberg, JR. , Richard E. Gautney , Derek G. Kane , Dane Fawkes , Thomas J. Bollenbach , Michael C. Tilley , Stuart A. Jacobson , John F. Mannisto
IPC分类号： C12M1/36 , C12M3/00 , C12M1/34 , C12M1/00 , C12M1/12 , C12N5/00 , C12M1/26 , A61L27/38 , B33Y10/00 , B33Y30/00 , B33Y70/00 , A01N1/02
摘要： A system and method for growing and maintaining biological material including producing a protein associated with the tissue, selecting cells associated with the tissue, expanding the cells, creating at least one tissue bio-ink including the expanded cells, printing the at least one tissue bio-ink in at least one tissue growth medium mixture, growing the tissue from the printed at least one tissue bio-ink, and maintaining viability of the tissue.
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公开(公告)号：US20240254427A1
公开(公告)日：2024-08-01
申请号：US18443395
申请日：2024-02-16
发明人： Christopher C. Langenfeld , David D.B Cannan , Dirk A. Van Der Merwe , Dean Kamen , Jason A. Demers , Frederick Morgan , Timothy D. Moreau , Brian D. Tracey , Matthew Ware , Richard J. Lanigan , Michael A. Baker , David Blumberg, JR. , Richard E. Andrews , Derek G. Kane , Dane C. Fawkes , Thomas J. Bollenbach , Michael C. Tilley , Stuart A. Jacobson , John F. Mannisto
IPC分类号： C12M1/36 , A01N1/02 , A61L27/38 , B33Y10/00 , B33Y30/00 , B33Y70/00 , C12M1/00 , C12M1/12 , C12M1/26 , C12M1/34 , C12M3/00 , C12N5/00
CPC分类号： C12M41/48 , A01N1/0247 , A61L27/3895 , B33Y10/00 , B33Y30/00 , B33Y70/00 , C12M21/08 , C12M23/22 , C12M23/38 , C12M25/02 , C12M27/18 , C12M29/00 , C12M33/00 , C12M37/02 , C12M41/12 , C12M41/40 , C12M41/46 , C12N5/0018 , C12N5/0062 , C12N2533/00 , C12N2533/50 , C12N2533/90
摘要： A system and method for growing and maintaining biological material including producing a protein associated with the tissue, selecting cells associated with the tissue, expanding the cells, creating at least one tissue bio-ink including the expanded cells, printing the at least one tissue bio-ink in at least one tissue growth medium mixture, growing the tissue from the printed at least one tissue bio-ink, and maintaining viability of the tissue.
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公开(公告)号：US11299705B2
公开(公告)日：2022-04-12
申请号：US15805790
申请日：2017-11-07
发明人： Christopher C. Langenfeld , David D. B. Cannan , Dirk A. van der Merwe , Dean Kamen , Jason A. Demers , Frederick Morgan , Timothy D. Moreau , Brian D. Tracey , Matthew Ware , Richard J. Lanigan , Michael A. Baker , David Blumberg, Jr. , Richard E. Gautney , Derek G. Kane , Dane Fawkes , Thomas J. Bollenbach , Michael C. Tilley , Stuart A. Jacobson , John F. Mannisto
IPC分类号： C12M3/00 , C12M1/00 , C12M1/36 , C12M1/34 , C12M1/12 , C12N5/00 , C12M1/26 , A61L27/38 , B33Y10/00 , B33Y30/00 , B33Y70/00 , A01N1/02
摘要： A system and method for growing and maintaining biological material including producing a protein associated with the tissue, selecting cells associated with the tissue, expanding the cells, creating at least one tissue bio-ink including the expanded cells, printing the at least one tissue bio-ink in at least one tissue growth medium mixture, growing the tissue from the printed at least one tissue bio-ink, and maintaining viability of the tissue.
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公开(公告)号：US20190218501A1
公开(公告)日：2019-07-18
申请号：US16360330
申请日：2019-03-21
发明人： Dean Kamen , Jason A. Demers , Frederick Morgan , Timothy D. Moreau , Brian D. Tracey , Matthew Ware , Dirk A. van der Merwe , Richard J. Lanigan , Michael A. Baker , David Blumberg, JR.
摘要： A fluid pumping and bioreactor system including at least two cassettes, at least one storage reservoir, at least one bioreactor, at least one manifold including valve modules, and tubing to connect the cassettes to the storage reservoir and the bioreactor. The cassettes can include pumps, valves, and fluid conduits and can be communicatively connected to the at least one manifold. The bioreactor can include an adapter and fluid conduits extending through the adapter from the exterior of the bioreactor to the interior of the bioreactor. System and method for generating a tissue for transplant by decellularizing and recellularizing a supplied tissue.
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