公开(公告)号：US20220297031A1

公开(公告)日：2022-09-22

申请号：US17608940

申请日：2020-05-12

申请人： Puridify Ltd

发明人： Shameer Subratty ,  Klaus Gebauer ,  Anindya Sengupta ,  Anji Venna ,  Hannes Hjorter ,  Adam Pinnock ,  Ralph Stankowski

IPC分类号： B01D15/22 ,  B01D15/26 ,  B01D15/18 ,  B01J20/26 ,  B01J20/28 ,  B01J20/285

摘要： A chromatography device (1; 101) comprising: —at least one chromatography material unit (3), wherein said chromatography material unit comprises a convection-based chromatography material; —at least one fluid distribution system (7) which is configured to distribute fluid into and out from the at least one chromatography material unit (3); —an inlet (15); —at least one inlet fluid channel (17a, 17b) connecting the inlet (15) with each chromatography material unit (3) via the fluid distribution system (7); —an outlet (19); and —at least one outlet fluid channel (21) connecting the outlet (19) with each chromatography material unit (3) via the fluid distribution system (7), wherein at least some parts of said chromatography device (1; 101) are overmolded and sealed together by plastic or elastomer leaving at least the inlet (15) and the outlet (19) open.

公开(公告)号：US20220242895A1

公开(公告)日：2022-08-04

申请号：US17621987

申请日：2020-06-11

申请人： IFP Energies nouvelles

发明人： Catherine LAROCHE ,  Maria MANKO ,  Emmanuelle BRACCO

IPC分类号： C07H1/06 ,  C07H3/02 ,  B01D15/26

摘要： The invention relates to a process for the liquid-phase separation of glucose from a mixture of C5 and C6 sugars comprising at least xylose and glucose, by adsorption of glucose on a zeolitic adsorbent based on FAU-type zeolite crystals having an Si/Al atomic ratio strictly greater than 1.5 comprising barium, wherein: said mixture is brought into contact with said adsorbent, by liquid chromatography, to obtain a xylose-enriched liquid phase and a glucose-enriched adsorbed phase; on the one hand, said xylose-enriched liquid phase is recovered and said phase adsorbed on said adsorbent is desorbed by means of a desorption solvent in order to recover the glucose on the other hand.

公开(公告)号：US20210170342A1

公开(公告)日：2021-06-10

申请号：US16770899

申请日：2018-12-13

申请人： King Abdullah University of Science and Technology

发明人： Giada SOLDAN ,  Suzana NUNES

IPC分类号： B01D69/02 ,  B01D71/80 ,  B01D71/02 ,  B01D71/28 ,  B01D15/38 ,  B01D15/34 ,  B01D15/26 ,  C07K1/16

摘要： Embodiments of the present disclosure describe functionalized polymeric membranes including one or more dithiol compounds that extend from a nanoparticle provided on or near a surface and/or pores of a polymer material, wherein at least one thiol of the dithiol compound binds to the nanoparticle and at least one thiol of the dithiol compound is a free thiol. Embodiments of the present disclosure further describe methods of separating and/or recovering a purified antibody comprising contacting a feed stream containing an antibody and other biomolecules with a functionalized polymeric membrane to separate the antibody from the feed stream; and applying a reducing agent to release the antibody from the membrane and recover a purified antibody; wherein the functionalized polymeric membrane includes a plurality of free thiols selective to binding the antibody.

公开(公告)号：US10669233B2

公开(公告)日：2020-06-02

申请号：US16358659

申请日：2019-03-19

申请人： SUNRESIN NEW MATERIALS CO. LTD., XI AN ,  BLUESTAR ADISSEO NANJING CO., LTD.

发明人： Xiaokang Kou ,  Risheng Wang ,  Gang Wang ,  Qiong Liu ,  Wanping Ren ,  Julien Boutet ,  Yuanbin Yang ,  Valentin Guidal

IPC分类号： C07C319/28 ,  C07C323/58 ,  A61K31/145 ,  B01J20/285 ,  B01D15/26 ,  B01D15/12 ,  B01D15/42

摘要： The present invention provides a process for purifying methionine. A methionine product having a purity of up to 99% or higher is obtained by separating methionine from a salt by-product through a process comprising adsorption and desorption using a macroporous adsorption resin, where the methionine content in the salt by-product is ≤0.03%. The yield of methionine extracted with the resin is up to 98% or higher. By using the process of the present invention, the existing production process is simplified, the quality of the methionine product is improved, and the production costs for methionine are reduced.

公开(公告)号：US20200023289A1

公开(公告)日：2020-01-23

申请号：US16587268

申请日：2019-09-30

申请人： BIOTECHFLOW LTD

发明人： Martin John HOFMANN

IPC分类号： B01D15/18 ,  B01D15/22 ,  B01D15/26 ,  C07K1/22 ,  G01N30/60

摘要： A separation column for expanded bed adsorption comprises a column tube (2), a base (15) carrying an inlet rotor structure (6) for pumping in process liquid, and a top cap (3). The top cap (3) is conical in form, and has a peripheral flange 31 by which it is rigidly fixed to the top edge flange (22) of the column tube (2). The angle of the convergent interior surface (35) of the conical top cap (3) may be between 10 and 25°. A vortex-inhibitor component (8) projects down below the outlet structure (4) at the top of the cap, projecting into the operating space (15) of the column to inhibit rotation of liquid in the column interior. An expanded bed adsorption process is done with upward flow of liquid in the column through a bed of media particles.

公开(公告)号：US20190217273A1

公开(公告)日：2019-07-18

申请号：US16359328

申请日：2019-03-20

申请人： Waters Technologies Corporation

发明人： Kevin D. Wyndham ,  Michael F. Morris ,  Darryl W. Brousmiche ,  Jason F. Hill ,  Jacob N. Fairchild

IPC分类号： B01J20/283 ,  C07F7/18 ,  B01J20/28 ,  B01D15/26 ,  B01D15/30 ,  B01D15/32 ,  B01D15/40 ,  B01J20/288 ,  B01J20/32 ,  B01J20/289 ,  B01D53/02 ,  B01J20/22 ,  B01J20/30

CPC分类号： B01J20/283 ,  B01D15/26 ,  B01D15/30 ,  B01D15/305 ,  B01D15/322 ,  B01D15/40 ,  B01D53/025 ,  B01J20/22 ,  B01J20/28004 ,  B01J20/28016 ,  B01J20/28042 ,  B01J20/28057 ,  B01J20/28059 ,  B01J20/28061 ,  B01J20/28064 ,  B01J20/28066 ,  B01J20/28069 ,  B01J20/28071 ,  B01J20/28073 ,  B01J20/28076 ,  B01J20/28078 ,  B01J20/28083 ,  B01J20/28085 ,  B01J20/282 ,  B01J20/284 ,  B01J20/285 ,  B01J20/288 ,  B01J20/289 ,  B01J20/3085 ,  B01J20/32 ,  B01J20/3204 ,  B01J20/3206 ,  B01J20/3208 ,  B01J20/3234 ,  B01J20/3246 ,  B01J20/3285 ,  B01J20/3293 ,  B01J2220/54 ,  B01J2220/80 ,  C07F7/1804

摘要： In one aspect, the present invention provides a chromatographic stationary phase material for various different modes of chromatography represented by Formula 1: [X](W)a(Q)b(T)c (Formula 1). X can be a high purity chromatographic core composition having a surface comprising a silica core material, metal oxide core material, an inorganic-organic hybrid material or a group of block copolymers thereof. W can be absent and/or can include hydrogen and/or can include a hydroxyl on the surface of X. Q can be a functional group that minimizes retention variation over time (drift) under chromatographic conditions utilizing low water concentrations. T can include one or more hydrophilic, polar, ionizable, and/or charged functional groups that chromatographically interact with the analyte. Additionally, b and c can be positive numbers, with the ratio 0.05≤(b/c)≤100, and a≥0.

公开(公告)号：US20190211272A1

公开(公告)日：2019-07-11

申请号：US16358545

申请日：2019-03-19

申请人： The University of Wyoming Research Corporation dba Western Research Institute

发明人： John F. Schabron ,  Joseph F. Rovani, JR. ,  Jean-Pascal Planche

IPC分类号： C10G25/00 ,  B01D15/26 ,  B01D15/00 ,  G01N30/46 ,  C10G53/08 ,  G01N33/28 ,  B01J20/281 ,  B01J20/286 ,  B01J20/287 ,  C10G25/12 ,  G01N30/14 ,  B01J20/284 ,  B01J20/283

CPC分类号： C10G25/003 ,  B01D15/00 ,  B01D15/265 ,  B01J20/281 ,  B01J20/283 ,  B01J20/284 ,  B01J20/286 ,  B01J20/287 ,  C10G25/12 ,  C10G53/08 ,  C10G2400/30 ,  G01N30/14 ,  G01N30/461 ,  G01N30/468 ,  G01N33/2823 ,  G01N33/2835 ,  G01N2030/027 ,  G01N2030/085 ,  G01N2030/143 ,  G01N2030/8854

摘要： A method for determining asphaltene stability in a hydrocarbon-containing material having solvated asphaltenes therein is disclosed. In at least one embodiment, it involves the steps of: (a) precipitating an amount of the asphaltenes from a liquid sample of the hydrocarbon-containing material with an alkane mobile phase solvent in a column; (b) dissolving a first amount and a second amount of the precipitated asphaltenes by changing the alkane mobile phase solvent to a final mobile phase solvent having a solubility parameter that is higher than the alkane mobile phase solvent; (c) monitoring the concentration of eluted fractions from the column; (d) creating a solubility profile of the dissolved asphaltenes in the hydrocarbon-containing material; and (e) determining one or more asphaltene stability parameters of the hydrocarbon-containing material.

公开(公告)号：US20190187109A1

公开(公告)日：2019-06-20

申请号：US16223330

申请日：2018-12-18

申请人： Waters Technologies Corporation

发明人： Moon Chul Jung ,  Abhijit Tarafder ,  Wade P. Leveille

IPC分类号： G01N30/14 ,  B01D15/26 ,  B01D15/18

CPC分类号： G01N30/14 ,  B01D15/18 ,  B01D15/26 ,  G01N1/34 ,  G01N30/32 ,  G01N30/34 ,  G01N2030/143 ,  G01N2030/342

摘要： In various aspects provided are purification media and containers for dispensing a purified liquid are provided herein where a high surface area-to-volume chemically interactive purification media positioned at the outlet of a container that purifies the liquid as it is dispensed and/or extracted.

公开(公告)号：US10265453B2

公开(公告)日：2019-04-23

申请号：US14646846

申请日：2013-11-05

申请人： GAMBRO LUNDIA AB

发明人： Ralf Flieg ,  Stephan Aldinger ,  Markus Storr ,  Bernd Krause

IPC分类号： A61M1/16 ,  A61M1/26 ,  A61M1/34 ,  A61M1/36 ,  B01D15/26 ,  B01D15/32 ,  B01D61/24 ,  B01D61/30 ,  B01D63/02 ,  B01D63/04 ,  B01D69/02 ,  B01D69/08 ,  B01D69/14 ,  B01D71/42 ,  B01D71/56 ,  B01D71/68 ,  B01J20/10 ,  B01J20/20 ,  B01J20/26 ,  B01J20/28 ,  B01J47/014 ,  D01D5/24 ,  B01D15/36

摘要： An artificial, extracorporeal system for liver replacement and/or assistance, comprises a liver dialysis device for conducting hemodialysis on a patient suffering from liver failure. The liver dialysis device comprises a first standard hollow fiber membrane dialyzer which does not allow passage of an essential amount of albumin over the membrane wall and which is perfused with the patient's blood, and a second hollow fiber membrane dialyzer which allows the passage of essential but defined amounts of albumin over the membrane wall and which receives the blood of the first standard hemodialyzer. The filtrate space is closed off from the lumen space of the hollow fibers and is populated by adsorbent material which may comprise one or more different adsorbents.

公开(公告)号：US10247455B2

公开(公告)日：2019-04-02

申请号：US15208825

申请日：2016-07-13

申请人： Hanon Systems

发明人： Alex Dziubinschi ,  Kastriot Shaska ,  James L. Smitterberg ,  Brennan Sicks

IPC分类号： F25B43/00 ,  B01D29/00 ,  B60H1/32 ,  B01D15/26 ,  B01D29/52 ,  B01D29/03

摘要： A receiver drier comprises a housing and a filter unit. The housing includes a moisture absorbing chamber and a longitudinally spaced filter chamber. The filter chamber includes an inlet formed adjacent a first portion of an inner circumferential surface thereof and an outlet formed adjacent a second portion of the inner circumferential surface. The filter unit is received within the filter chamber and includes a main body defining a first filter compartment therein. A first surface of the first filter compartment is defined by a first screen element fluidly coupling an interior of the first filter compartment to an exterior thereof. The flow of the refrigerant enters and exits the first filter compartment while flowing in a direction substantially perpendicular to the longitudinal direction of the receiver drier.