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公开(公告)号：US20210346866A1
公开(公告)日：2021-11-11
申请号：US17376567
申请日：2021-07-15
Applicant: Puridify Ltd.
Inventor： Marc Hummersone , Benjamin Wallis , Frederic Leroux , William Law
IPC: B01J20/26 , B01D15/20 , B01D15/38 , B01J20/28 , B01J20/289 , B01J20/30 , B01J20/32 , C07K1/16 , B01J20/286
Abstract: Functionalised polymeric chromatography medium, comprising: at least one non-woven sheet comprising one or more polymeric nanofibers having a mean diameter of 10-1000 nm; one or more polymer chains grafted onto the one or more polymeric nanofibers, wherein the polymer chains are poly-glycerol chains comprising glycidol monomer residues or wherein the polymer chains comprise divinylsulfone monomer residues; and at least one ligand group bonded to the one or more polymer chains.
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公开(公告)号：US10696714B2
公开(公告)日：2020-06-30
申请号：US16422102
申请日：2019-05-24
Applicant: Puridify Ltd.
Inventor： Daniel Gilbert Bracewell , Robert Stevens , Oliver Hardick
IPC: C07K1/16 , B01D15/36 , B01J20/28 , B01J20/30 , C07K1/18 , C07K1/22 , B01J20/24 , B82Y30/00 , B01D15/18 , B01D15/38 , B01J20/285
Abstract: The present invention provides a chromatography medium comprising one or more electrospun polymer nanofibres which in use form a stationary phase comprising a plurality of pores through which a mobile phase can permeate and use of the same.
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公开(公告)号：US12070735B2
公开(公告)日：2024-08-27
申请号：US17078435
申请日：2020-10-23
Applicant: Puridify Ltd.
Inventor： Oliver Hardick , Daniel Gilbert Bracewell , Stewart Dods
IPC: B01D39/14 , B01D15/32 , B01D15/36 , B01D15/38 , B01D39/16 , B01J20/24 , B01J20/26 , B01J20/28 , B01J20/285 , B01J20/287 , B01J20/288 , B01J20/30 , B01J39/05 , B01J39/19 , B01J39/26 , B01J41/07 , B01J41/13 , B01J41/20 , B29C65/00 , B29C65/02 , B32B5/02 , B32B27/08 , B32B27/12 , B32B27/32 , B32B37/06 , B32B37/10 , B32B37/18 , C07K1/16 , C07K1/18 , C07K1/20 , C07K1/22 , B29K601/00 , B29K627/18 , B29L9/00 , C12M1/12
CPC classification number: B01J20/265 , B01D15/327 , B01D15/361 , B01D15/362 , B01D15/363 , B01D15/38 , B01D15/3804 , B01D15/3809 , B01D15/3819 , B01D39/14 , B01D39/16 , B01D39/1623 , B01J20/24 , B01J20/28007 , B01J20/28033 , B01J20/28038 , B01J20/28083 , B01J20/28085 , B01J20/285 , B01J20/287 , B01J20/288 , B01J20/3007 , B01J20/3085 , B01J39/05 , B01J39/19 , B01J39/26 , B01J41/07 , B01J41/13 , B01J41/20 , B29C65/02 , B29C66/45 , B29C66/712 , B29C66/7294 , B32B5/022 , B32B27/08 , B32B27/12 , B32B27/322 , B32B37/06 , B32B37/10 , B32B37/182 , C07K1/165 , C07K1/18 , C07K1/20 , C07K1/22 , B01J2220/54 , B29K2601/12 , B29K2627/18 , B29K2713/00 , B29L2009/00 , B32B2262/04 , B32B2317/18 , B32B2327/18 , C07K1/16 , C12M25/14
Abstract: The present invention provides a process for preparing a functionalised polymeric chromatography medium, which process comprises (I) providing two or more non-woven sheets stacked one on top of the other, each said sheet comprising one or more polymer nanofibres, (II) simultaneously heating and pressing the stack of sheets to fuse points of contact between the nanofibres of adjacent sheets, and (III) contacting the pressed and heated product with a reagent which functionalises the product of step (II) as a chromatography medium.
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公开(公告)号：US20240109003A1
公开(公告)日：2024-04-04
申请号：US17768671
申请日：2020-11-19
Applicant: PURIDIFY LTD
Inventor： Lennart Sörby
CPC classification number: B01D15/247 , B01D15/3804 , B01D15/424 , G01N30/82
Abstract: The present invention relates to a method for controlling fraction collection of a target product 27 in a chromatography system 49 configured for cyclic purification performed on a sample comprising the target product 27. The method comprises determining trigger points for target product 27 collection in relation to presence of target product in the outlet; setting a first time period based on the trigger points within which the elution in the first cycle is captured; evaluating timing of the captured elution to identify the next time period; applying the timing to capture elution during the elution phase in the following cycle; and collecting the captured elution in the following cycle. The last three steps are repeated to capture the elution during the elution phase of the following cycles until no more target product 27 is desired.
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Patent Agency Ranking
公开(公告)号：US20230173407A1
公开(公告)日：2023-06-08
申请号：US17996777
申请日：2021-04-27
Applicant: Puridify Ltd
Inventor： Matthew Townsend , Ian Scanlon , Ola Lind , Gunnar Malmquist
CPC classification number: B01D15/1885 , B01D15/203 , B01D15/424 , B01D15/247
Abstract: The present invention relates to a preparative chromatography system (200, 500, 800) and a chromatography process (400, 700) adapted to repetitive cycling of chromatography volumes. The system (200, 500, 800) comprises at least two upstream pumps (203a, 803a, 203b, 803b) and separate flow paths (220) from process liquid sources to the chromatography device (200, 500, 800). The system (200, 500, 800) is arranged to prime one flow path (220) with one process liquid while providing another process liquid to the chromatography device and thereby minimizing the hold-up volume of the system (200, 500, 800).
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7.发明申请公开(公告)号：US20190308169A1
公开(公告)日：2019-10-10
申请号：US16315088
申请日：2017-07-14
Applicant: Puridify Ltd.
Inventor： Marc Hummersone , Benjamin Wallis , Frederic Leroux , William Law
Abstract: The present invention provides a functionalised polymeric chromatography medium, prepared by a process which comprises (i) providing a substrate formed of one or more polymer nanofibres, (ii) grafting one or more neutral polymer chains from the substrate, and (iii) contacting the grafted product with a reagent which functionalises the product of step (ii) as a chromatography medium, wherein step (ii) comprises reacting a plurality of compounds of formula and/or its enantiomers, and/or its derivatives of formula (I) and/or enantiomers and/or diastereomers thereof: with one or more functional groups present on the nanofibre substrate, wherein R1, R2, R3, R4 and R5 may be the same or different, and are chosen from H, halogen, C1-C4 alkyl, or C1-C4 alkoxy provided that at least one of R1, R2, R3, R4 or R5 is not hydrogen.
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公开(公告)号：US11998890B2
公开(公告)日：2024-06-04
申请号：US17376567
申请日：2021-07-15
Applicant: Puridify Ltd.
Inventor： Marc Hummersone , Benjamin Wallis , Frederic Leroux , William Law
IPC: B01D15/20 , B01D15/38 , B01J20/26 , B01J20/28 , B01J20/286 , B01J20/289 , B01J20/30 , B01J20/32 , C07K1/16
CPC classification number: B01J20/265 , B01D15/20 , B01D15/3809 , B01J20/28023 , B01J20/28038 , B01J20/28052 , B01J20/286 , B01J20/289 , B01J20/3085 , B01J20/3092 , B01J20/321 , B01J20/3212 , B01J20/3217 , B01J20/3219 , B01J20/3227 , B01J20/3248 , B01J20/3272 , B01J20/328 , B01J20/3293 , C07K1/16 , B01J2220/62
Abstract: Functionalised polymeric chromatography medium, comprising: at least one non-woven sheet comprising one or more polymeric nanofibers having a mean diameter of 10-1000 nm; one or more polymer chains grafted onto the one or more polymeric nanofibers, wherein the polymer chains are poly-glycerol chains comprising glycidol monomer residues or wherein the polymer chains comprise divinylsulfone monomer residues; and at least one ligand group bonded to the one or more polymer chains.
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公开(公告)号：US20220168667A1
公开(公告)日：2022-06-02
申请号：US17437132
申请日：2020-03-31
Applicant: Puridify Ltd.
Inventor： Ian Scanlon , Anna Gronberg , Matthew Townsend
IPC: B01D15/18 , B01D15/14 , B01D15/38 , B01D15/36 , B01J20/286 , B01J20/28 , B01J41/20 , B01J47/127
Abstract: A chromatography system comprising at least two chromatography units (3) connected in parallel, wherein said at least two chromatography units (3) each comprises a convection-based chromatography material, wherein an initial difference in back pressure provided from the different chromatography units (3) is compensated dynamically during run of the system due to a change of chromatography unit properties provided during the chromatography process.
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