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298 条记录 (耗时 0.031 秒)

    Collection System For Purification Flowstreams
    92.
    发明申请
    Collection System For Purification Flowstreams 有权
    净化流动收集系统

    公开(公告)号：US20130186831A1

    公开(公告)日：2013-07-25

    申请号：US13063571

    申请日：2009-11-12

    申请人： Harbaksh Sidhu ,  Ziqiang Wang

    发明人： Harbaksh Sidhu ,  Ziqiang Wang

    IPC分类号： G01N30/82

    CPC分类号： B01D15/10 ,  G01N30/02 ,  G01N30/82 ,  G01N2030/324 ,  B01D15/40

    摘要： A collection system for collecting samples from a flowstream (5) exiting a supercritical fluid chromatography system is provided. The collection system comprises: (i) a first back pressure regulator (10) on the flowstream as it exits the chromatography system, (ii) a gas-liquid separator (30) having a tapered and angled dripper (65), which introduces the flow into the separator at an angle tangential to the separator wall; and (iii) one or more fraction collectors (15), wherein the fraction collector is at a reduced pressure collection point, between 100 bar and atmospheric pressure. A collection system for HPLC is also provided, as well as a process for collection of samples from a flowstream.

    摘要翻译： 提供了一种从离开超临界流体色谱系统的流动流（5）收集样品的收集系统。 所述收集系统包括：（i）当其离开色谱系统时，流动流上的第一背压调节器（10），（ii）具有锥形和倾斜式滴水器（65）的气液分离器（30），其引入 以与分隔壁相切的角度流入分离器; 和（iii）一种或多种馏分收集器（15），其中馏分收集器处于100巴和大气压之间的减压收集点。 还提供了用于HPLC的收集系统，以及从流动流收集样品的方法。

    Low noise back pressure regulator for supercritical fluid chromatography
    93.
    发明授权
    Low noise back pressure regulator for supercritical fluid chromatography 有权
    用于超临界流体色谱的低噪音背压调节器

    公开(公告)号：US08419936B2

    公开(公告)日：2013-04-16

    申请号：US12730223

    申请日：2010-03-23

    申请人： Terry A. Berger ,  Samuel Colgate ,  Michael Casale

    发明人： Terry A. Berger ,  Samuel Colgate ,  Michael Casale

    IPC分类号： B01D15/08

    CPC分类号： B01D15/10 ,  B01D15/163 ,  G01N30/02 ,  G01N30/28 ,  Y10T137/7904 ,  B01D15/40

    摘要： A drive mechanism for back pressure regulator used in liquid chromatography, supercritical fluid chromatography, or supercritical fluid extraction allows very fine automated control over a very wide range of pressures by combining a linear actuator compressing a spring, pushing a pin. The nozzle assembly of the regulator comprises a flow through chamber containing a diaphragm and a seat, in which the pin pushes the diaphragm against the seat, together with an upstream pressure sensor and electronic feedback control to the motor of the actuator. The BPR of the embodiments exhibits high pressure stability and extremely low pressure noise, even at moderate to high pressures. The exemplary BPR can be use at either constant pressure or to generate pressure programs where the pressure is varied versus time. Further, the nozzle assembly has a field-replaceable head, requiring no mechanical adjustment on replacement.

    摘要翻译： 用于液相色谱，超临界流体色谱或超临界流体萃取的背压调节器的驱动机构通过组合压缩弹簧的线性致动器，推动销，可以在非常宽的压力范围内进行非常精细的自动化控制。 调节器的喷嘴组件包括流通室，其包含隔膜和座，其中销将隔膜压靠在座上，以及上游压力传感器和电子反馈控制到致动器的电动机。 实施例的BPR表现出高压稳定性和极低压力噪声，即使在中等至高压下。 示例性BPR可以在恒定压力下使用或产生压力程序，其中压力随时间变化。 此外，喷嘴组件具有现场可更换头部，在更换时不需要机械调节。

    Process flowstream collection system
    95.
    发明授权
    Process flowstream collection system 有权
    流程流收集系统

    公开(公告)号：US08262760B2

    公开(公告)日：2012-09-11

    申请号：US13009291

    申请日：2011-01-19

    申请人： Kimber D. Fogelman ,  Vincent Worley ,  Peter Sullivan

    发明人： Kimber D. Fogelman ,  Vincent Worley ,  Peter Sullivan

    IPC分类号： B01D50/00

    CPC分类号： B01D11/0203 ,  B01D11/0403 ,  B01D11/0407 ,  B01D11/0484 ,  B01D15/40 ,  B01D19/0021 ,  B01D19/0052 ,  Y10T137/3003 ,  G01N30/80

    摘要： A device and process for separating liquid and gas phases in a flowstream containing a liquefied gas or supercritical fluid under pressure mixed with a liquid. A splitter vessel separates the liquid from gas phases and transfers liquid to a collection container while conducting the gas phase out of the splitter. Separation of liquid phase out of the flowstream is provided without additional pressure schemes or solvent extractions imposed on the stream.

    摘要翻译： 一种用于在含有与液体混合的压力下的液化气体或超临界流体的流动流中分离液相和气相的装置和方法。 分流器容器将液体与气相分离，并将液体转移到收集容器，同时将气相从分离器中排出。 没有额外的压力方案或施加在流上的溶剂萃取提供从流动流中分离出液相。

    Method of manufacturing substances by supercritical fluid chromatography
    96.
    发明授权
    Method of manufacturing substances by supercritical fluid chromatography 有权
    超临界流体色谱法制造物质的方法

    公开(公告)号：US08158004B2

    公开(公告)日：2012-04-17

    申请号：US13138672

    申请日：2009-10-22

    申请人： Kenichiro Miyazawa ,  Takeshi Ishiguro

    发明人： Kenichiro Miyazawa ,  Takeshi Ishiguro

    IPC分类号： B01D15/08

    CPC分类号： G01N30/34 ,  B01D15/166 ,  B01D15/40 ,  G01N30/84

    摘要： Provided is a method of manufacturing target substances with use of supercritical fluid chromatography, by which the following are achieved: solution of a problem at the time of sequential injections of samples containing the target substances; an increase of a treatment amount of separation per unit time; and improvement of efficiency in separation. The method includes the steps of: injecting the sample containing the target substances into a mobile phase; and returning composition of the mobile phase to a pre-change state after changing the composition of the mobile phase. The step of returning the composition of the mobile phase to the pre-change state after changing the composition of the mobile phase is performed during a period of time from detection of a peak of one of the target substances which is eluted latest from a column among the target substances separated by the supercritical fluid chromatography apparatus to injection of the next sample, whereby the problem is solved.

    摘要翻译： 提供了使用超临界流体色谱法制造目标物质的方法，通过该方法实现以下目的：在连续注射含有目标物质的样品时的问题的解决方案; 每单位时间处理量的增加; 并提高分离效率。 该方法包括以下步骤：将含有目标物质的样品注入流动相中; 并且在改变流动相的组成之后将流动相的组成返回到预改变状态。 在改变流动相的组成之后将流动相的组成返回到改变前状态的步骤是在检测到最近从柱中洗脱的目标物质的一个峰的一段时间内进行的 由超临界流体色谱仪分离的目标物质注入下一个样品，从而解决了问题。

    Pressure Control Apparatus For Supercritical Fluid
    97.
    发明申请
    Pressure Control Apparatus For Supercritical Fluid 有权
    超临界流体压力控制装置

    公开(公告)号：US20110094606A1

    公开(公告)日：2011-04-28

    申请号：US12912957

    申请日：2010-10-27

    申请人： Takeshi Kanomata ,  Kazuharu Okubo ,  Seiji Horioka

    发明人： Takeshi Kanomata ,  Kazuharu Okubo ,  Seiji Horioka

    IPC分类号： F16K31/02

    CPC分类号： G01N30/32 ,  B01D15/40 ,  G01N2030/328 ,  G05D16/202 ,  Y10T137/7759 ,  Y10T137/7761

    摘要： An object of the present invention is to provide a pressure control apparatus for a supercritical fluid in which variation in pressure is small even in measurement in which analysis conditions are changed with time to improve separation and other performance. That is, a pressure control apparatus for a supercritical fluid according to the present invention includes: a valve comprising; a valve chamber provided in a midway of a channel through which a supercritical fluid passes; and an electrically-operated valve element located in the valve chamber; wherein a front end of the valve element fits into the valve chamber when the valve is closed, and it travels backward when the valve is opened; a pressure detection member for detecting the pressure of the supercritical fluid in the channel on an upstream or downstream side of the valve chamber; an open/close control member for controlling the pressure detected by the pressure detection member to be a target pressure; and a valve-opening rate adjustment member for adjusting the valve-opening rate when the valve is opened based on the state of the supercritical fluid.

    摘要翻译： 本发明的目的是提供一种超临界流体的压力控制装置，其中即使在分析条件随时间而改变以进行分离等性能的测量中，压力变化也很小。 也就是说，根据本发明的用于超临界流体的压力控制装置包括：阀，包括： 阀室，设置在超临界流体通过的通道的中间; 以及位于阀室中的电动阀元件; 其中当所述阀关闭时，所述阀元件的前端装配到所述阀室中，并且当所述阀打开时其向后移动; 压力检测部件，用于检测阀室的上游侧或下游侧的通道内的超临界流体的压力; 用于将由压力检测构件检测的压力控制为目标压力的打开/关闭控制构件; 以及阀开度调节构件，用于基于超临界流体的状态来调节阀打开时的开阀率。

    Supercritical-Phase Mixed Chromatography Method and Installation for Implementing Same
    99.
    发明申请
    Supercritical-Phase Mixed Chromatography Method and Installation for Implementing Same 有权
    超临界相混合色谱法及其实施方法

    公开(公告)号：US20090049891A1

    公开(公告)日：2009-02-26

    申请号：US11885023

    申请日：2006-02-22

    申请人： Mohamed Shaimi

    发明人： Mohamed Shaimi

    IPC分类号： G01N30/72 ,  G01N30/04

    CPC分类号： G01N30/466 ,  B01D15/1864 ,  B01D15/247 ,  G01N30/02 ,  G01N2030/326 ,  G01N2030/628 ,  B01D15/40

    摘要： A method for the superficial-phase chromatography of a product comprises the steps which are performed continuously in the following order, namely: an operation consisting in pumping a supercritical fluid; and operation consisting of injecting at least one sample of product into at least one chromatography column, a detection operation, and a fraction collection operation. The method comprises at least a first diversion along between an analytical channel and a preparatory channel, which diversion is performed prior to the supercritical fluid pumping operation and the analytical and preparatory channels each including respective supercritical fluid pumping operations. The method is also characterized in that the collection operation is common to both the analytical and preparatory channels. An installation used to implement one such method is described.

    摘要翻译： 产品的浅色相色谱法包括以下顺序连续进行的步骤，即：泵送超临界流体的操作; 以及包括将至少一个产品样品注入至少一个色谱柱中的操作，检测操作和馏分收集操作。 该方法包括在分析通道和预备通道之间的至少第一转移，其在超临界流体泵送操作之前执行转移，并且分析和预备通道各自包括相应的超临界流体泵送操作。 该方法的特征还在于收集操作对分析和预备通道是共同的。 描述用于实现一种这样的方法的安装。