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    Benzyl compound
    1.
    发明授权
    Benzyl compound 有权

    公开(公告)号：US11591351B2

    公开(公告)日：2023-02-28

    申请号：US17032357

    申请日：2020-09-25

    申请人： SEKISUI MEDICAL CO., LTD.

    发明人： Shinya Yano ,  Yuki Wakasugi ,  Yosuke Iwanaga

    IPC分类号： C07F7/18 ,  C07B51/00 ,  C07K1/06

    摘要： The purpose of the present invention is to provide a protecting group which improves the solubility of a compound having a functional group protected with the protecting group in an organic solvent and which is easily separated and purified after a reaction with avoiding solidification or insolubilization. Provided is a benzyl compound represented by Formula (1) where X1 represents —CH2OR14 (where R14 represents a hydrogen atom, a halogenocarbonyl group, or an active ester-type protecting group), —CH2NHR5 (where R15 represents a hydrogen atom, a linear or branched alkyl group having 1 to 6 carbon atoms, or an aralkyl group), a halogenomethyl group, a methyl azide group, a formyl group, or an oxime; and at least one of R1, R2, R3, R4, and R5 is a group represented by Formula (2), and the remainders each represent a hydrogen atom, a halogen atom, an alkyl group having 1 to 4 carbon atoms, or an alkoxy group having 1 to 4 carbon atoms, where R6 represents a linear or branched alkylene group having 1 to 16 carbon atoms; X2 represents O or CONR16 (where R16 represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms); and A represents a group represented by Formula (3), (4), (5), (6), (7), (8), (9), (10), (11), (12), or (13).

    Diphenylmethane protective agent
    4.
    发明授权
    Diphenylmethane protective agent 有权

    公开(公告)号：US10851120B2

    公开(公告)日：2020-12-01

    申请号：US16307105

    申请日：2017-06-19

    申请人： SEKISUI MEDICAL CO., LTD.

    发明人： Shinya Yano ,  Hideki Kubota

    IPC分类号： C07F7/18 ,  C07B51/00

    摘要： An object of the present invention is to develop a protecting group, which can prevent solidification or insolubilization of a compound by protecting a functional group to achieve easy separation and purification after a reaction.A diphenylmethane compound represented by general formula (1): wherein Y represents —OR19 (wherein R19 represents a hydrogen atom or an active ester-type protecting group), —NHR20 (wherein R20 represents, for example, a hydrogen atom, a C1-6 linear or branched alkyl group, or an aralkyl group, at least one of R1 to R10 represents a group represented by formula (2): —O—O—R11—X-A  (2) and the others each independently represent a hydrogen atom, a halogen atom, a C1-4 alkyl group, or a C1-4 alkoxy group; R11 represents a C1-16 linear or branched alkylene group; X represents O or CONR21 (wherein R21 represents a hydrogen atom, or a C1-4 alkyl group; and A represents, for example, a group represented by formula (3).

    Pyrrole derivative and process for producing the same
    8.
    发明申请
    Pyrrole derivative and process for producing the same 审中-公开
    吡咯衍生物及其制备方法

    公开(公告)号：US20050222241A1

    公开(公告)日：2005-10-06

    申请号：US10520050

    申请日：2003-06-30

    申请人： Masahiko Kato ,  Akira Kaneko

    发明人： Masahiko Kato ,  Akira Kaneko

    IPC分类号： C07B51/00 ,  C07D495/04 ,  A61K31/407 ,  C07D498/02

    CPC分类号： C07D495/04

    摘要： An object of the present invention is to provide novel pyrrole derivatives and processes for producing the derivatives, and to provide novel pyrrole derivatives (intermediates) which may be used as a starting material for the pyrrole derivatives and processes for producing the derivatives (intermediates). The pyrrole derivatives may be characterized by being represented by the formulae [1] and [2] wherein R1 and R2 each independently represents a hydrogen atom or a substituted or unsubstituted C1-10 hydrocarbon group and Z represents an organic group; and the process for producing the compound represented by the formula [1] may be characterized by separating Z from the compound represented by the formula [2].

    摘要翻译： 本发明的目的是提供新颖的吡咯衍生物和衍生物的制备方法，并提供可用作吡咯衍生物的起始原料的新颖的吡咯衍生物（中间体）及其制备方法（中间体）。 吡咯衍生物的特征可以由式[1]和[2]表示，其中R 1和R 2各自独立地表示氢原子或取代或未取代的 C 1-10烃基，Z表示有机基团; 并且由式[1]表示的化合物的制备方法的特征在于将Z与式[2]表示的化合物分离。