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公开(公告)号：US10822357B2
公开(公告)日：2020-11-03
申请号：US15755705
申请日：2016-08-25
发明人： Shinya Yano , Yuki Wakasugi , Yosuke Iwanaga
摘要： The purpose of the present invention is to provide a protecting group which improves the solubility of a compound having a functional group protected with the protecting group in an organic solvent and which is easily separated and purified after a reaction with avoiding solidification or insolubilization. Provided is a benzyl compound represented by Formula (1) where X1 represents —CH2OR14 (where R14 represents a hydrogen atom, a halogenocarbonyl group, or an active ester-type protecting group), —CH2NHR15 (where R15 represents a hydrogen atom, a linear or branched alkyl group having 1 to 6 carbon atoms, or an aralkyl group), a halogenomethyl group, a methyl azide group, a formyl group, or an oxime; and at least one of R1, R2, R3, R4, and R5 is a group represented by Formula (2), and the remainders each represent a hydrogen atom, a halogen atom, an alkyl group having 1 to 4 carbon atoms, or an alkoxy group having 1 to 4 carbon atoms, where R6 represents a linear or branched alkylene group having 1 to 16 carbon atoms; X2 represents O or CONR16 (where R16 represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms); and A represents a group represented by Formula (3), (4), (5), (6), (7), (8), (9), (10), (11), (12), or (13).
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公开(公告)号：US10508124B2
公开(公告)日：2019-12-17
申请号：US16319581
申请日：2017-07-24
发明人： Shinya Yano , Toshihiro Mori , Hideki Kubota
摘要： To develop a protecting group that facilitates separation and purification, after reaction, of a compound including a protected functional group, without solidifying or insolubilizing the compound.A xanthene compound of by General Formula (1) (wherein Y is —OR17 (R17 is a hydrogen atom or an active ester-protecting group), —NHR18 (R18 is a hydrogen atom, or a linear or branched C1-C6 alkyl group or aralkyl group), an azide, a halogen atom, or a carbonyl group formed together with a methylene group; at least one of R1 to R8 is represented by Formula (2); —O—R9—X-A (2) and a residue is a hydrogen atom, a halogen atom, a C1-C4 alkyl group, or a C1-C4 alkoxy group, wherein R9 is a linear or branched C1-C16 alkylene group; X is O or CONR19 (R19 is a hydrogen atom or a C1-C4 alkyl group); and A is represented by Formula (3) or the like (wherein R10, R11, and R12, the same or different, are a linear or branched C1-C6 alkyl group or an aryl group optionally including a substituent; R13 is a single bond or a linear or branched C1-C3 alkylene group; and R14, R15, and R16 are a linear or branched C1-C3 alkylene group)).
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公开(公告)号：US11542287B2
公开(公告)日：2023-01-03
申请号：US17105855
申请日：2020-11-27
发明人： Shinya Yano , Kenta Saito , Hideki Kubota
IPC分类号： C07F7/18 , C07B63/04 , C07C43/23 , C07C211/27 , C07C265/08
摘要： Provided is an alkyldiphenylmethane protective agent, which can prevent solidification or insolubilization of a compound by protecting a functional group of the compound to achieve easy separation and purification after a reaction.
An alkyldiphenylmethane compound represented by general formula (1): wherein Y represents —OR19 (wherein R19 represents a hydrogen atom or an active ester-type protecting group), —NHR20 (wherein R20 represents a hydrogen atom, a C1-6 linear or branched alkyl group, or an aralkyl group), isocyanate group, an azide group, or a halogen atom, Z represents a C1-4 linear or branched alkyl group, an alkenyl group, or a cycloalkyl group, at least one of R1 to R10 represents a group represented by formula (2): —O—R11—X-A (2) and the others each independently represent a hydrogen atom, a halogen atom, a C1-4 alkyl group, or a C1-4 alkoxy group; R11 represents a C1-16 linear or branched alkylene group; X represents O or CONR21 (wherein R21 represents a hydrogen atom or a C1-4 alkyl group); and A represents, for example, a group represented by formula (3): wherein R12, R13, and R14 may be the same or different and each independently represent a C1-6 linear or branched alkyl group or an optionally substituted aryl group; R15 represents a single bond or a C1-3 linear or branched alkylene group; and R16, R17, and R18 each independently represent a C1-3 linear or branched alkylene group.-
公开(公告)号：US11485747B2
公开(公告)日：2022-11-01
申请号：US17074668
申请日：2020-10-20
发明人： Shinya Yano , Hideki Kubota
摘要： An object of the present invention is to develop a protecting group, which can prevent solidification or insolubilization of a compound by protecting a functional group to achieve easy separation and purification after a reaction.
A diphenylmethane compound represented by general formula (1): wherein Y represents —OR19 (wherein R19 represents a hydrogen atom or an active ester-type protecting group), —NHR20 (wherein R20 represents, for example, a hydrogen atom, a C1-6 linear or branched alkyl group, or an aralkyl group, at least one of R1 to R10 represents a group represented by formula (2): —O—R11—X-A (2) and the others each independently represent a hydrogen atom, a halogen atom, a C1-4 alkyl group, or a C1-4 alkoxy group; R11 represents a C1-16 linear or branched alkylene group; X represents O or CONR21 (wherein R21 represents a hydrogen atom, or a C1-4 alkyl group; and A represents, for example, a group represented by formula (3).-
公开(公告)号：US11591351B2
公开(公告)日：2023-02-28
申请号：US17032357
申请日：2020-09-25
发明人： Shinya Yano , Yuki Wakasugi , Yosuke Iwanaga
摘要： The purpose of the present invention is to provide a protecting group which improves the solubility of a compound having a functional group protected with the protecting group in an organic solvent and which is easily separated and purified after a reaction with avoiding solidification or insolubilization. Provided is a benzyl compound represented by Formula (1) where X1 represents —CH2OR14 (where R14 represents a hydrogen atom, a halogenocarbonyl group, or an active ester-type protecting group), —CH2NHR5 (where R15 represents a hydrogen atom, a linear or branched alkyl group having 1 to 6 carbon atoms, or an aralkyl group), a halogenomethyl group, a methyl azide group, a formyl group, or an oxime; and at least one of R1, R2, R3, R4, and R5 is a group represented by Formula (2), and the remainders each represent a hydrogen atom, a halogen atom, an alkyl group having 1 to 4 carbon atoms, or an alkoxy group having 1 to 4 carbon atoms, where R6 represents a linear or branched alkylene group having 1 to 16 carbon atoms; X2 represents O or CONR16 (where R16 represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms); and A represents a group represented by Formula (3), (4), (5), (6), (7), (8), (9), (10), (11), (12), or (13).
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公开(公告)号：US10851120B2
公开(公告)日：2020-12-01
申请号：US16307105
申请日：2017-06-19
发明人： Shinya Yano , Hideki Kubota
摘要： An object of the present invention is to develop a protecting group, which can prevent solidification or insolubilization of a compound by protecting a functional group to achieve easy separation and purification after a reaction.A diphenylmethane compound represented by general formula (1): wherein Y represents —OR19 (wherein R19 represents a hydrogen atom or an active ester-type protecting group), —NHR20 (wherein R20 represents, for example, a hydrogen atom, a C1-6 linear or branched alkyl group, or an aralkyl group, at least one of R1 to R10 represents a group represented by formula (2): —O—O—R11—X-A (2) and the others each independently represent a hydrogen atom, a halogen atom, a C1-4 alkyl group, or a C1-4 alkoxy group; R11 represents a C1-16 linear or branched alkylene group; X represents O or CONR21 (wherein R21 represents a hydrogen atom, or a C1-4 alkyl group; and A represents, for example, a group represented by formula (3).
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公开(公告)号：US10981940B2
公开(公告)日：2021-04-20
申请号：US16347415
申请日：2017-11-10
发明人： Shinya Yano , Hideki Kubota
IPC分类号： C07F7/18
摘要： The invention is to develop a protecting group that does not solidify or insolubilize a compound in which a functional group has been protected, and facilitates separation and purification after a reaction. Disclosed is a trityl compound represented by General Formula (1): wherein Y represents a hydroxy group or a halogen atom; at least one of R1 to R15 represents a group represented by Formula (2): —O—R16—X-A (2) while the other groups each represent a hydrogen atom, a halogen atom, an alkyl group having 1 to 4 carbon atoms, or an alkoxy group having 1 to 4 carbon atoms; R16 represents a linear or branched alkylene group having 1 to 16 carbon atoms; X represents O or CONR17 (here, R17 represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms); and A represents a group represented by, for example, Formula (3): wherein R18, R19, and R20, which may be identical or different, each represent a linear or branched alkyl group having 1 to 6 carbon atoms, or an aryl group which may have a substituent.
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