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公开(公告)号：US11149041B2
公开(公告)日：2021-10-19
申请号：US16305875
申请日：2017-05-30
IPC分类号： C07F5/00 , C07C213/02 , C07C227/02 , C07C227/18 , C07C269/04 , C07C269/06 , C07C271/02 , C07C303/04 , C07C309/24
摘要： The present invention discloses a novel process for the preparation of gadolinium complex of (4S)-4-(4-Ethoxybenzyl)-3,6,9-tris(carboxylatomethyl)-3,6,9-triazaundecanedioic acid disodium of formula 1 and novel intermediates thereof.
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公开(公告)号：US10882813B2
公开(公告)日：2021-01-05
申请号：US15536807
申请日：2015-12-17
发明人： Manik Reddy Pullagurla , Mecheril Valsan Nanda Kumar , Jagadeesh Babu Rangisetty , Rajesh Bhudeti , Radha Nagarapu
IPC分类号： C07C51/41 , C07C51/43 , A23L33/16 , A23L33/165 , C07C59/265
摘要： The present invention relates to an improved method for the synthesis of Ferric Citrate and also to provide an amorphous form of Ferric Citrate having an active surface area less than 14 sq.m/g.
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公开(公告)号：US10647655B2
公开(公告)日：2020-05-12
申请号：US16329770
申请日：2017-09-01
发明人： Manik Reddy Pullagurla , Mecheril Valsan Nanda Kumar , Madhusudhana Rao Veligetla , Jagadeesh Babu Rangisetty
摘要： An improved method for the synthesis of substantially pure Permethrin having purity greater than 99.5% by Gas Chromatography provided. The embodiments also relates to a purification process of Permethrin by recrystallization from methanol-water mixture.
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4.发明授权Process for the preparation of (1-{9-[(4S, 2R, 3R, 5R)-3, 4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl)-6-aminopurin-2-yl}pyrazole-4-yl)-N-methylcarboxamide 有权制备（1- {9 - [（4S，2R，3R，5R）-3,4-二羟基-5-（羟甲基）氧杂环戊烷-2-基）-6-氨基嘌呤-2-基} 吡啶-4-基）-N-甲基甲酰胺公开(公告)号：US09580457B2
公开(公告)日：2017-02-28
申请号：US14438998
申请日：2013-10-28
IPC分类号： C07H19/22 , C07H19/16 , C07H1/00 , C07H19/167
CPC分类号： C07H19/16 , C07H1/00 , C07H19/167
摘要： The present invention relates to a novel process for the preparation of (1-{9-[(4S,2R,3R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl)-6-aminopurin-2-yl}pyrazole-4-yl)-N-methylcarboxamide.
摘要翻译： 本发明涉及制备（1- {9 - [（4S，2R，3R，5R）-3,4-二羟基-5-（羟甲基）氧杂环戊烷-2-基）-6-氨基嘌呤 -2-基}吡唑-4-基）-N-甲基甲酰胺。
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公开(公告)号：US20190047934A1
公开(公告)日：2019-02-14
申请号：US15536807
申请日：2015-12-17
发明人： Manik Reddy Pullagurla , Mecheril Valsan Nanda Kumar , Jagadeesh Babu Rangisetty , Rajesh Bhudeti , Radha Nagarapu
摘要： The present invention relates to an improved method for the synthesis of Ferric Citrate and also to provide an amorphous form of Ferric Citrate having an active surface area less than 14 sq.m/g.
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公开(公告)号：US10077251B2
公开(公告)日：2018-09-18
申请号：US15291087
申请日：2016-10-12
IPC分类号： C07D401/12 , C07D213/75
CPC分类号： C07D401/12 , C07D213/75
摘要： The present invention describes an improved process for the preparation of Dabigatran Etexilate (Formula-VII) or it's pharmaceutically acceptable salt for the treatment of thrombosis, cardiovascular diseases etc. and intermediates involved in the synthesis.
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公开(公告)号：US20180237377A1
公开(公告)日：2018-08-23
申请号：US15961831
申请日：2018-04-24
发明人： Manik Reddy Pullagurla , Jagadeesh Babu Rangisetty , Mecheril Valsan Nandakumar , Madhava Reddy Vedururi , Sreenu Samireddi
IPC分类号： C07C227/12 , C07C227/20 , C07C229/42 , C07C231/12 , C07C269/06 , C07C227/40 , C07C271/22 , C07C229/36
CPC分类号： C07C227/12 , C07B2200/07 , C07C227/16 , C07C227/20 , C07C227/40 , C07C231/12 , C07C269/06 , C07C271/22 , C07C229/36
摘要： The present invention relates to an improved process for the preparation of Melphalan, more specifically the invention relates to an efficient process for the preparation of substantially pure Melphalan hydrochloride (I).
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公开(公告)号：US20170298093A1
公开(公告)日：2017-10-19
申请号：US15513719
申请日：2015-08-29
发明人： Manik Reddy Pullagurla , Jagadeesh Babu Rangisetty , Mecheril Valsan Nanda Kumar , Surya Bala Subrahmanyam Pendyala , Bhaskar Reddy Pitta
IPC分类号： C07K5/107 , C07C237/20 , C07D303/36 , C07K1/14
CPC分类号： C07K5/1016 , C07C237/20 , C07D303/36 , C07K1/14 , C07K5/1008
摘要： Novel methods for preparation of Carfilzomib and intermediates thereof with high stereo selection are reported. The synthetic procedures result in substantially pure Carfilzomib (I).
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公开(公告)号：US20210284662A1
公开(公告)日：2021-09-16
申请号：US17258890
申请日：2019-07-10
摘要： The present invention relates to an improved process for the preparation of 2,2′,2″-(10-((2R,3S)-1,3,4-trihydroxy butan-2-yl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl) triacetic acid, gadolinium (III) with iron metal content less than 5 ppm and free gadolinium content less than 10 ppm, which is represented by the formula (1). The present invention further relates to an improved process for the preparation of calcium complex of 10-(2,3-Dihydroxy-1-(hydroxymethyl)propyl)-1,4,7,10-tetraazacyclo decane-1,4,7-triacetic acid known as Calcobutrol (1a) and its sodium salt of formula (1b) with purity greater than 98.0%.
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公开(公告)号：US20210206978A1
公开(公告)日：2021-07-08
申请号：US17150123
申请日：2021-01-15
摘要： This invention relates to an improved method for the preparation of highly or substantially pure Indigotindisulfonate sodium (1). It further relates to the novel crystalline form I of Indigotindisulfonate sodium (1) and the process for its preparation.
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