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    Process for the synthesis of Melphalan
    2.
    发明授权
    Process for the synthesis of Melphalan 有权

    公开(公告)号：US11787761B2

    公开(公告)日：2023-10-17

    申请号：US17757830

    申请日：2020-12-21

    申请人： Indena S.P.A.

    发明人： Pietro Allegrini ,  Andrea Bonetti ,  Marco Molinari ,  Andrea Gambini

    IPC分类号： C07C227/20

    CPC分类号： C07C227/20

    摘要： The invention relates to a process for the preparation of Melphalan (4-[bis(2-5 chloroethyl)amino]-L-phenylalanine of formula (I) said process comprising the reaction of a 4-amino-L-phenylalanine protected at the carboxy and amino aminoacidic groups with an agent able to convert the aromatic amino group into a group of formula: —N(CH2CH2OS(O)nO—)2, wherein n is 1 or 2 followed by conversion of the →N(CH2CH2OS(O)nO—)2 group into a —N(CH2CH2Cl)2 group. The invention also provides novel intermediates useful for the preparation of Melphalan.

    Process for producing long chain amino acids and dibasic acids
    7.
    发明授权
    Process for producing long chain amino acids and dibasic acids 有权

    公开(公告)号：US10343978B2

    公开(公告)日：2019-07-09

    申请号：US15880293

    申请日：2018-01-25

    申请人： Vitaworks IP, LLC

    发明人： Songzhou Hu

    IPC分类号： C07C227/00 ,  C07C227/08 ,  C07C229/08 ,  C07C51/47 ,  C07C227/40 ,  C07C209/62 ,  C07C227/20

    摘要： There is disclosed a process for the production of long chain amino acid and long chain dibasic acid, comprising: (1) reacting long chain keto fatty acid with hydroxylamine or subjecting keto fatty acid to an ammoximation reaction to yield an oxime fatty acid; (2) reacting the oxime fatty acid with an alcohol or a primary amine or a secondary amine to prepare an ester or amide; (3) subjecting the oxime fatty acid ester or amide to the Beckmann rearrangement to yield a mixture of two amide fatty acids; (4) hydrolyzing the mixed amide fatty acids to produce long chain amino acid, long chain dibasic acid, short chain alkylamine, and alkanoic acid.