公开(公告)号：US20220234994A1

公开(公告)日：2022-07-28

申请号：US17673335

申请日：2022-02-16

申请人： XWPHARMA LTD.

发明人： JIA-NING XIANG ,  HAO-WEI SHIH ,  XIAOMING WU ,  XUAN ZHANG ,  JAMES TIEN

IPC分类号： C07C229/08 ,  C07C227/20 ,  C07C227/18 ,  C07C271/22 ,  C07C269/06

摘要： The present disclosure is directed synthetic methods for the preparation of 4-valyloxybutyric acid. The synthetic methods described herein employ a diverse array of protecting group strategies and reaction conditions. Additionally, the present disclosure is directed to compounds useful as synthetic intermediates in the preparation of 4-valyloxybutyric acid.

公开(公告)号：US20230357130A1

公开(公告)日：2023-11-09

申请号：US18221075

申请日：2023-07-12

申请人： XWPHARMA LTD.

发明人： JIA-NING XIANG ,  HAO-WEI SHIH ,  XIAOMING WU ,  XUAN ZHANG ,  JAMES TIEN

IPC分类号： C07C229/08 ,  C07C227/18 ,  C07C227/20 ,  C07C269/06 ,  C07C271/22 ,  C07C227/16

CPC分类号： C07C229/08 ,  C07C227/18 ,  C07C227/20 ,  C07C269/06 ,  C07C271/22 ,  C07C227/16

摘要： The present disclosure is directed synthetic methods for the preparation of 4-valyloxybutyric acid. The synthetic methods described herein employ a diverse array of protecting group strategies and reaction conditions. Additionally, the present disclosure is directed to compounds useful as synthetic intermediates in the preparation of 4-valyloxybutyric acid.

公开(公告)号：US20240351975A1

公开(公告)日：2024-10-24

申请号：US18676957

申请日：2024-05-29

申请人： XWPHARMA LTD.

发明人： JIA-NING XIANG ,  HAO-WEI SHIH ,  XIAOMING WU ,  XUAN ZHANG ,  JAMES TIEN

IPC分类号： C07C229/08 ,  C07C227/16 ,  C07C227/18 ,  C07C227/20 ,  C07C269/06 ,  C07C271/22

CPC分类号： C07C229/08 ,  C07C227/16 ,  C07C227/18 ,  C07C227/20 ,  C07C269/06 ,  C07C271/22

摘要： The present disclosure is directed synthetic methods for the preparation of 4-valyloxybutyric acid. The synthetic methods described herein employ a diverse array of protecting group strategies and reaction conditions. Additionally, the present disclosure is directed to compounds useful as synthetic intermediates in the preparation of 4-valyloxybutyric acid.

公开(公告)号：US20240092727A1

公开(公告)日：2024-03-21

申请号：US18239265

申请日：2023-08-29

申请人： XWPHARMA LTD.

发明人： JIA-NING XIANG ,  XUESONG XU ,  XUAN ZHANG ,  JAMES TIEN ,  HAO-WEI SHIH ,  HSIN-YI HUANG

IPC分类号： C07C229/24 ,  A61K9/16 ,  A61K31/221

CPC分类号： C07C229/24 ,  A61K9/16 ,  A61K31/221 ,  C07B2200/13

摘要： Crystalline 4-((L-valyl)oxy)butanoic acid, methods of preparing crystalline 4-((L-valyl)oxy)butanoic acid, pharmaceutical compositions of crystalline 4-((L-valyl)oxy)butanoic acid, and methods of treatment using crystalline 4-((L-valyl)oxy)butanoic acid are disclosed.

公开(公告)号：US20220411365A1

公开(公告)日：2022-12-29

申请号：US17878174

申请日：2022-08-01

申请人： XWPHARMA LTD.

发明人： JIA-NING XIANG ,  XUESONG XU ,  HAO-WEI SHIH ,  WAI-SI ENG

IPC分类号： C07C271/24 ,  A61K9/00 ,  C07C211/35 ,  C07D213/80 ,  C07D305/06 ,  C07D309/08 ,  C07D317/68 ,  A61K31/165 ,  A61K31/166

摘要： Ketamine derivatives and pharmaceutical compositions thereof are disclosed. When administered orally the ketamine derivatives provide increased bioavailability of ketamine in the systemic circulation. The ketamine derivatives can be used to treat neurological diseases, psychological diseases and pain.

公开(公告)号：US20220055982A1

公开(公告)日：2022-02-24

申请号：US17351550

申请日：2021-06-18

申请人： XWPHARMA LTD.

发明人： JIA-NING XIANG ,  HAO-WEI SHIH ,  XIAOMING WU ,  XUAN ZHANG ,  JAMES TIEN

IPC分类号： C07C229/08 ,  C07C227/18 ,  C07C227/20

摘要： The present disclosure is directed synthetic methods for the preparation of 4-valyloxybutyric acid. The synthetic methods described herein employ a diverse array of protecting group strategies and reaction conditions. Additionally, the present disclosure is directed to compounds useful as synthetic intermediates in the preparation of 4-valyloxybutyric acid.