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公开(公告)号：US12180550B2
公开(公告)日：2024-12-31
申请号：US17292748
申请日：2019-11-08
Applicant: BRACCO IMAGING S.P.A.
Inventor： Andrea Ferraris , Erika Reitano , Alessandro Maiocchi
IPC: C12Q1/6886
Abstract: Disclosed are gene signatures and methods for predicting the recurrence of prostate cancer in prostatectomized subjects. Other objectives of the invention are assay devices and kits for determining the expression levels of specific gene sets correlated to prostate cancer recurrence.
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公开(公告)号：US20240425527A1
公开(公告)日：2024-12-26
申请号：US18719054
申请日：2022-12-13
Applicant: BRACCO IMAGING S.P.A.
Inventor： Sonia GAZZETTO , Valeria BOI , Andrea BANIN , Andrea BARALE
IPC: C07F5/00
Abstract: The invention relates to a process for the preparation of the gadolinium dimeric contrast agent [p-[1-[bis[2-(hydroxy-KO)-3-[4,7,10-tris[(carboxy-KO)methyl]-1,4,7,10-tetraazacyclododec-1-yl-K/V1,K/V4,K/V7,K/V10]propyl]amino]-1-deoxy-D-glucitolato(6-)]]di-gadolinium complex. Such process includes preparation steps carried out one-pot and without isolation of the obtained intermediates. The gadolinium dimeric contrast agent can be for use in diagnostic imaging, in particular in Magnetic resonance Imaging (MRI).
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公开(公告)号：US20230303592A1
公开(公告)日：2023-09-28
申请号：US18017939
申请日：2021-07-26
Applicant: BRACCO IMAGING S.P.A.
Inventor： Andrea BARALE , Valeria BOI , Aurelia FERRIGATO , Sonia GAZZETTO , Daniela GIARDINA-PAPA , Armando MORTILLARO , Laura ORIO , Massimo VERANI
IPC: C07F5/00
CPC classification number: C07F5/003
Abstract: The invention relates to a process for the preparation of dimeric contrast agents for use in Magnetic resonance Imaging (MRI), in particular [μ-[1-[bis[2-(hydroxy-kO)-3-[4,7,10-tris[(carboxy-kO)methyl]-1,4,7,10-tetraazacyclododec-1-yl-kN1,kN4,kN7,kN10]propyl]amino]-1-deoxy-D-glucitolato(6-)]]di-gadolinium complex, which includes preparation steps carried out one-pot and without isolation of the obtained intermediate.
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公开(公告)号：US20230040008A1
公开(公告)日：2023-02-09
申请号：US17786768
申请日：2020-12-16
Applicant: BRACCO IMAGING S.P.A.
Inventor： Erika REITANO , Alessandro MAIOCCHI , Luisa POGGI , Federico CRIVELLIN , Simon HUET , Mathieu CINIER , Olivier KITTEN
Abstract: The present invention provides new polypeptide derivatives binding to Human Epidermal Growth Factor Receptor 2 (HER2) and their conjugates thereof, and to their use as a diagnostic agent, particularly for early detection, patient stratification and treatment monitoring of forms of cancer characterized by over-expression of HER2.
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公开(公告)号：US20220348923A1
公开(公告)日：2022-11-03
申请号：US17642753
申请日：2020-09-16
Applicant: BRACCO IMAGING S.P.A.
Inventor： Vittorio DE FRANCISCIS , Carla Lucia ESPOSITO , Silvia CATUOGNO , Silvia NUZZO , Alessandro MAIOCCHI , Margherita IABONI , Aldo DI VITO , Erika REITANO , Luisa POGGI
IPC: C12N15/115 , C12Q1/6886 , A61K45/06
Abstract: The present invention provides nucleic acid aptamers binding to the Carbonic Anhydrase IX (CA-IX) enzyme, derivatives and conjugates thereof and their use as diagnostic tools, particularly for the imaging of organs and tissues expressing CA-IX, or as therapeutic agents for prevention or treatment of CA-IX related diseases.
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Patent Agency Ranking
公开(公告)号：US20210196840A1
公开(公告)日：2021-07-01
申请号：US17199122
申请日：2021-03-11
Applicant: BRACCO IMAGING S.P.A.
Inventor： Roberta NAPOLITANO , Luciano LATTUADA , Zsolt BARANYAI , Nicole GUIDOLIN , Giuseppe MARAZZI
Abstract: The present invention relates to the RRR/SSS pair of enantiomers of the of Gd(PCTA-tris-glutamic glutaric acid), the single enantiomers of the pair, the pharmaceutically acceptable salts thereof, their amide derivatives, and compositions comprising at least 50% of these compounds.
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公开(公告)号：US11021451B2
公开(公告)日：2021-06-01
申请号：US16916817
申请日：2020-06-30
Applicant: BRACCO IMAGING S.P.A.
Inventor： Luciano Lattuada , Roberta Napolitano , Valeria Boi , Massimo Visigalli , Silvio Aime , Giovanni Battista Giovenzana , Alberto Fringuello Mingo
IPC: C07D257/02 , A61K49/10 , C07D401/06
Abstract: The present invention relates to new class of functionalized macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.
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公开(公告)号：US11007283B2
公开(公告)日：2021-05-18
申请号：US16092905
申请日：2017-04-05
Applicant: BRACCO IMAGING S.P.A.
Inventor： Luciano Lattuada , Roberta Napolitano , Valeria Boi , Massimo Visigalli , Silvio Aime , Giovanni Battista Giovenzana , Alberto Fringuello Mingo
IPC: A61K49/10 , A61B5/055 , C07F9/6524 , C07D257/02 , G01R33/56
Abstract: The present invention relates to new class of functionalized polyazamacrocycles including at least one phosphonic or phosphinic group linked to a nitrogen atom of the macrocyclic cage, and capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.
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公开(公告)号：US20200317722A1
公开(公告)日：2020-10-08
申请号：US16769633
申请日：2018-12-05
Applicant: BRACCO IMAGING S.P.A.
Inventor： Raphael CAMPANELLA , Anthony CLOUET , Luciano LATTUADA
Abstract: The present invention discloses a solid-phase process for the preparation of a Near Infra-Red (NIR) fluorescent probe characterized by an aza-bicycloalkane based cyclic peptide labelled with a Cy5.5 dye moiety and used in the guided surgery of tumors and pathologic regions.
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公开(公告)号：US10738000B2
公开(公告)日：2020-08-11
申请号：US16276252
申请日：2019-02-14
Applicant: BRACCO IMAGING S.P.A.
Inventor： Roberta Fretta , Pietro Delogu , Fernanda Di Giorgio , Alfonso Nardelli , Stefano Sguassero , Carlo Felice Viscardi
IPC: C07C67/08 , C07C67/287 , C07C51/44 , B01D3/00 , C07C67/54
Abstract: The present invention relates to a method for the acetylation of an aqueous solution of lactic acid to (S)-2-acetyloxypropionic acid.The process comprises in particular removing water from the solution of lactic acid and reacting lactic acid with acetic anhydride in the presence of acetic acid.
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