公开(公告)号：US10377700B2

公开(公告)日：2019-08-13

申请号：US15912772

申请日：2018-03-06

申请人： BRACCO IMAGING S.P.A.

发明人： Elisa Battistini ,  Federica Buonsanti ,  Daniela Imperio ,  Luciano Lattuada ,  Roberta Napolitano

IPC分类号： C07C231/14 ,  C07C231/02 ,  C07F5/04 ,  C07F5/05 ,  C07C201/12 ,  C07C227/04 ,  C07C231/12 ,  C07F5/02 ,  C07C237/46

摘要： The present invention discloses a process for recovery of a boronic acid of formula R3—B(OH)2, wherein R3 is selected from the group consisting of C1-C6 linear or branched alkyl, C3-C6 cycloalkyl, and C6 aryl, optionally substituted with a group selected from the group consisting of methyl, ethyl, n-propyl, i-propyl, n-butyl, sec-butyl, t-butyl, and phenyl, comprising admixing the boronic acid with a water-immiscible organic solvent in a weight ratio between the boronic acid and the water-immiscible organic solvent from 1:10 to 1:20, adding an aqueous solution to a final pH of neutral, and partitioning the boronic acid into an organic water-immiscible phase and recovery of the organic water-immiscible phase.

公开(公告)号：US09381257B2

公开(公告)日：2016-07-05

申请号：US14414224

申请日：2013-07-04

申请人： BRACCO IMAGING S.P.A.

发明人： Pernille Rose Jensen ,  Magnus Karlsson ,  Mathilde H. Lerche ,  Roberta Napolitano ,  Fabio Tedoldi ,  Massimo Visigalli

IPC分类号： A61K49/10 ,  A61K49/20 ,  C07F7/08 ,  G01R33/28

CPC分类号： A61K49/10 ,  A61K49/20 ,  C07F7/0812 ,  C07F7/0814 ,  G01R33/282

摘要： New radical compounds, useful in the field of MRI imaging of formula (I). The radical compounds are in particular new triarylmethyl (“trityl”) radicals which can be used as polarizing agents for polarizing a molecule in the DNP process.

摘要翻译： 新的自由基化合物，可用于式（I）的MRI成像领域。 自由基化合物特别是新的三芳基甲基（“三苯甲基”）基团，其可以用作在DNP方法中使分子偏振的偏振剂。

公开(公告)号：US11021451B2

公开(公告)日：2021-06-01

申请号：US16916817

申请日：2020-06-30

申请人： BRACCO IMAGING S.P.A.

发明人： Luciano Lattuada ,  Roberta Napolitano ,  Valeria Boi ,  Massimo Visigalli ,  Silvio Aime ,  Giovanni Battista Giovenzana ,  Alberto Fringuello Mingo

IPC分类号： C07D257/02 ,  A61K49/10 ,  C07D401/06

摘要： The present invention relates to new class of functionalized macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.

公开(公告)号：US11007283B2

公开(公告)日：2021-05-18

申请号：US16092905

申请日：2017-04-05

申请人： BRACCO IMAGING S.P.A.

发明人： Luciano Lattuada ,  Roberta Napolitano ,  Valeria Boi ,  Massimo Visigalli ,  Silvio Aime ,  Giovanni Battista Giovenzana ,  Alberto Fringuello Mingo

IPC分类号： A61K49/10 ,  A61B5/055 ,  C07F9/6524 ,  C07D257/02 ,  G01R33/56

摘要： The present invention relates to new class of functionalized polyazamacrocycles including at least one phosphonic or phosphinic group linked to a nitrogen atom of the macrocyclic cage, and capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.

公开(公告)号：US20150151009A1

公开(公告)日：2015-06-04

申请号：US14414224

申请日：2013-07-04

申请人： BRACCO IMAGING S.P.A.

发明人： Pernille Rose Jensen ,  Magnus Karlsson ,  Mathilde H. Lerche ,  Roberta Napolitano ,  Fabio Tedoldi ,  Massimo Visigalli

IPC分类号： A61K49/10 ,  C07F7/08

CPC分类号： A61K49/10 ,  A61K49/20 ,  C07F7/0812 ,  C07F7/0814 ,  G01R33/282

摘要： New radical compounds, useful in the field of MRI imaging of formula (I). The radical compounds are in particular new triarylmethyl (“trityl”) radicals which can be used as polarizing agents for polarizing a molecule in the DNP process.

摘要翻译： 新的自由基化合物，可用于式（I）的MRI成像领域。 自由基化合物特别是新的三芳基甲基（“三苯甲基”）基团，其可以用作在DNP方法中使分子偏振的偏振剂。

公开(公告)号：US10973934B2

公开(公告)日：2021-04-13

申请号：US16766619

申请日：2019-08-06

申请人： BRACCO IMAGING S.P.A.

发明人： Roberta Napolitano ,  Luciano Lattuada ,  Zsolt Baranyai ,  Nicole Guidolin ,  Giuseppe Marazzi

IPC分类号： A61B5/055 ,  A61K49/10 ,  C07F5/00

摘要： The present invention relates to the RRR/SSS pair of enantiomers of the of Gd(PCTA-tris-glutaric acid), the single enantiomers of the pair, the pharmaceutically acceptable salts thereof, their amide derivatives, and compositions comprising at least 50% of these compounds.

公开(公告)号：US10781188B2

公开(公告)日：2020-09-22

申请号：US16060577

申请日：2016-12-12

申请人： BRACCO IMAGING S.P.A.

发明人： Luciano Lattuada ,  Roberta Napolitano ,  Valeria Boi ,  Massimo Visigalli ,  Silvio Aime ,  Giovanni Battista Giovenzana ,  Alberto Fringuello Mingo

IPC分类号： C07D257/02 ,  A61K49/10 ,  C07D401/06

摘要： The present invention relates to new class of functionalized macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.

公开(公告)号：US10407412B2

公开(公告)日：2019-09-10

申请号：US16060754

申请日：2016-12-12

申请人： BRACCO IMAGING S.P.A.

发明人： Valeria Boi ,  Roberta Napolitano ,  Luciano Lattuada

IPC分类号： A61B5/055 ,  C07D403/12 ,  C07D257/02 ,  A61K49/12 ,  A61K49/10

摘要： The present invention relates to new class of dimeric macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.

公开(公告)号：US12036289B2

公开(公告)日：2024-07-16

申请号：US17199122

申请日：2021-03-11

申请人： BRACCO IMAGING S.P.A.

发明人： Roberta Napolitano ,  Luciano Lattuada ,  Zsolt Baranyai ,  Nicole Guidolin ,  Giuseppe Marazzi

IPC分类号： A61B5/055 ,  A61K49/10 ,  C07F5/00 ,  C07D471/08

CPC分类号： A61K49/106 ,  C07F5/003 ,  A61K49/108 ,  C07D471/08

摘要： The present invention relates to the RRR/SSS pair of enantiomers of the of Gd(PCTA-tris-glutaric acid), the single enantiomers of the pair, the pharmaceutically acceptable salts thereof, their amide derivatives, and compositions comprising at least 50% of these compounds.

公开(公告)号：US11851421B2

公开(公告)日：2023-12-26

申请号：US18010905

申请日：2021-06-22

申请人： BRACCO IMAGING S.P.A.

发明人： Francesco Blasi ,  Federica Buonsanti ,  Federico Crivellin ,  Andrea Ferraris ,  Laura Orio ,  Lorena Pizzuto ,  Roberta Napolitano ,  Giovanni Valbusa

IPC分类号： C07D403/10 ,  C09B23/01 ,  C07D403/14

CPC分类号： C07D403/10 ,  C07D403/14 ,  C09B23/0066 ,  C09B23/0075

摘要： The present invention relates to the field of optical imaging. More particularly, it relates to compounds of the cyanine family with near-infrared emission characterized by improved physico-chemical and biological properties and to conjugates with biological ligands thereof. The invention also relates to the use of these compounds as optical diagnostic agents in imaging or therapy of solid tumors, to the methods for their preparation and to the compositions comprising them. The compounds have formula (I), formula (I), wherein X is direct bond or —O—; Y is a group selected from linear or branched C1-C6 alkyl, C3-C7 cycloalkyl and heterocyclyl, substituted by at least two hydroxyl groups; R1 and R2 are each independently a linear or branched C1-C6 alkyl substituted by a group selected from —SO3H, —COOH, —CONH2 and —COO—C1-C6 alkyl; and R3 is hydrogen, —SO3H or a linear or branched C1-C6 alkyl substituted by —COOH or —CONH—Y, wherein Y is a group selected from linear or branched C1-C6 alkyl, C3-C7 cycloalkyl and heterocyclyl, substituted by at least two hydroxyl groups.