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公开(公告)号：US20240290472A1
公开(公告)日：2024-08-29
申请号：US18568441
申请日：2022-10-14
Applicant: BRACCO IMAGING S.P.A.
Inventor： Giovanni Valbusa , Sonia Colombo Serra , Alberto Fringuello Mingo , Fabio Tedoldi , David Bella
CPC classification number: G16H30/40 , A61B6/481 , G06T5/50 , G06T5/92 , G06T2207/10081 , G06T2207/10088 , G06T2207/20081 , G06T2207/20212 , G06T2207/30004
Abstract: A solution is proposed relating to medical imaging applications. Particularly, a method (600) for imaging a body-part of a patient comprises simulating (624-630) corresponding operative simulation images from an operative baseline image and operative administration images, which operative administration images have been acquired with administration of a contrast agent at an operative administration-dose: the operative simulation images mimic administration of the contrast agent at a higher dose. For this purpose, a machine learning model (420) is used that has been trained to optimize a capability thereof to mimic a corresponding increase of the contrast agent from a sample source-dose to a sample target-dose: the sample source-dose is different from the operative administration-dose. Corresponding computer program (500) and computer program product for implementing the imaging method (600) are proposed. Moreover, a computing system (115) for performing the imaging method (600) and an imaging system (105) comprising the computing system (115) and a scanner (110) are proposed. A medical method based on the same imaging method (600) is further proposed.
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2.发明授权公开(公告)号：US10583209B2
公开(公告)日：2020-03-10
申请号：US16363193
申请日：2019-03-25
Applicant: BRACCO IMAGING S.P.A.
Inventor： Mathilde H. Lerche , Pernille Rose Jensen , Magnus Karlsson , Roberta Napolitano , Claudia Cabella , Luigi Miragoli , Sonia Colombo Serra , Fabio Tedoldi
Abstract: 1-13C-1,1-Bis(acetoxy(methyl))-2,2′-cyclopropane of formula (I): The compound can be hyperpolarized and used as a contrast agent in 13C Magnetic Resonance diagnostic technique (13C-MR) for the diagnosis of tumor.
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公开(公告)号：US20150273086A1
公开(公告)日：2015-10-01
申请号：US14437521
申请日：2013-10-24
Applicant: BRACCO IMAGING S.P.A.
Inventor： Claudia Cabella , Lara Caminiti , Sonia Colombo Serra , Pernille Rose Jensen , Magnus Karlsson , Mathilde H. Lerche , Luigi Miragoli , Luisa Poggi , Fabio Tedoldi , Luca Venturi
IPC: A61K49/10
Abstract: Hyperpolarized 1-13C-2-oxoglutarate as contrast agent in 13C Magnetic Resonance diagnostic technique (13C-MRI) for use in the diagnosis of cancer. In particular, upon administration of said 1-13C-2-oxoglutarate, signals of 1-13C-glutamate are detected. More in particular, different MR signals from 13C nuclei are detected and compared, said comparison being useful to determine a difference between tumor and non-tumor tissues, to determine the aggressiveness of a tumor or the efficacy of an anti-tumor therapy.
Abstract translation: 超极化1-13C-2-氧戊酸作为造影剂在13C磁共振诊断技术（13C-MRI）中用于诊断癌症。 特别地，在施用所述1-13C-2-氧戊二酸酯时，检测出1-13C谷氨酸的信号。 更具体地，检测和比较来自13C核的不同MR信号，所述比较可用于确定肿瘤和非肿瘤组织之间的差异，以确定肿瘤的侵袭性或抗肿瘤治疗的功效。
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公开(公告)号：US20150151009A1
公开(公告)日：2015-06-04
申请号：US14414224
申请日：2013-07-04
Applicant: BRACCO IMAGING S.P.A.
Inventor： Pernille Rose Jensen , Magnus Karlsson , Mathilde H. Lerche , Roberta Napolitano , Fabio Tedoldi , Massimo Visigalli
CPC classification number: A61K49/10 , A61K49/20 , C07F7/0812 , C07F7/0814 , G01R33/282
Abstract: New radical compounds, useful in the field of MRI imaging of formula (I). The radical compounds are in particular new triarylmethyl (“trityl”) radicals which can be used as polarizing agents for polarizing a molecule in the DNP process.
Abstract translation: 新的自由基化合物，可用于式（I）的MRI成像领域。 自由基化合物特别是新的三芳基甲基（“三苯甲基”）基团，其可以用作在DNP方法中使分子偏振的偏振剂。
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公开(公告)号：US09693828B2
公开(公告)日：2017-07-04
申请号：US14362447
申请日：2012-12-03
Applicant: BRACCO IMAGING S.P.A.
Inventor： Silvio Aime , Sonia Colombo Serra , Pernille Rose Jensen , Magnus Karlsson , Mathilde H. Lerche , Fabio Tedoldi , Massimo Visigalli
CPC classification number: A61B34/20 , A61B5/055 , A61B2090/374 , A61K49/106 , A61K49/108 , G01R33/286
Abstract: The present invention generally relates to a composition comprising acetic anhydride, a DNP agent and a gadolinium complex and its use for the preparation of hyperpolarised imaging agent for MR diagnostic analysis.
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Patent Agency Ranking
6.发明授权Process for the preparation of hyperpolarized derivatives for use in MRI analysis 有权用于制备用于MRI分析的超极化衍生物的方法公开(公告)号：US09511154B2
公开(公告)日：2016-12-06
申请号：US14350478
申请日：2012-10-11
Applicant: BRACCO IMAGING S.P.A.
Inventor： Silvio Aime , Sonia Colombo Serra , Giovanni Battista Giovenzana , Pernille Rose Jensen , Magnus Karlsson , Mathilde H. Lerche , Fabio Tedoldi
CPC classification number: A61K49/10 , C07B59/001 , G01R33/5601
Abstract: The present invention relates to a process for the preparation of aqueous solutions of hyperpolarized carboxylic organic acids ready for use in in-vivo MR diagnostic imaging, and the use of the corresponding anhydrides or esters as glass-forming agents.
Abstract translation: 本发明涉及准备用于体内MR诊断成像的超极化羧酸有机酸的水溶液的制备方法，以及相应的酸酐或酯作为玻璃形成剂的用途。
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7.发明申请Composition Comprising Acetic Anhydride And A Gadolinium Complex, And Method For The Use In Hyperpolarisation In MRI Analysis 有权包含乙酸酐和钆配合物的组合物，以及在MRI分析中用于超极化的方法公开(公告)号：US20140343402A1
公开(公告)日：2014-11-20
申请号：US14362447
申请日：2012-12-03
Applicant: BRACCO IMAGING S.P.A.
Inventor： Silvio Aime , Sonia Colombo Serra , Pernille Rose Jensen , Magnus Karlsson , Mathilde H. Lerche , Fabio Tedoldi , Massimo Visigalli
CPC classification number: A61B34/20 , A61B5/055 , A61B2090/374 , A61K49/106 , A61K49/108 , G01R33/286
Abstract: The present invention generally relates to a composition comprising acetic anhydride, a DNP agent and a gadolinium complex and its use for the preparation of hyperpolarised imaging agent for MR diagnostic analysis.
Abstract translation: 本发明一般涉及包含乙酸酐，DNP剂和钆络合物的组合物及其用于制备用于MR诊断分析的超极化成像剂的用途。
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8.发明公开公开(公告)号：US20240273362A1
公开(公告)日：2024-08-15
申请号：US18568454
申请日：2022-10-14
Applicant: BRACCO IMAGING S.P.A.
Inventor： Giovanni Valbusa , Sonia Colombo Serra , Alberto Fringuello Mingo , Fabio Tedoldi , Davide Bella
CPC classification number: G06N3/08 , G06N20/00 , G06T7/0012 , G16H30/00 , G06T2207/20081 , G06T2207/20084
Abstract: A solution is proposed for training a machine learning model (420) for use in medical imaging applications. A corresponding method (700) comprises providing (703-743: 759-763) sample sets, each comprising a sample baseline image, a sample target image (acquired from a corresponding body-part of a subject to which a contrast agent at a certain dose has been administered) and a sample source dose (corresponding to a different dose of the contrast agent). The machine learning model (420) is trained (744-758) so as to optimize its capability of generating each sample target image from the corresponding sample baseline image and sample source image. One or more of the sample sets are incomplete, missing their sample source images. Each incomplete sample set is completed (704-742: 759-763) by simulating the sample source image from at least the sample baseline image and the sample target image of the sample set. A computer programs (500) and a computer program products for implementing the method (700) are proposed. Moreover, a computing system (130) for performing the method (700) is proposed.
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公开(公告)号：US10265421B2
公开(公告)日：2019-04-23
申请号：US14764568
申请日：2014-01-30
Applicant: BRACCO IMAGING S.P.A.
Inventor： Pernille Rose Jensen , Lerche H. Mathilde , Magnus Karlsson , Claudia Cabella , Sonia Colombo Serra , Luigi Miragoli , Luca Venturi , Fabio Tedoldi
Abstract: The invention relates to a method of Magnetic Resonance (MR) detection, in particular 13C-MR detection, by using a diagnostic medium comprising a hyperpolarized ester, in particular ethyl acetoacetate. The method comprises the detection of the MR signal of a hyperpolarized 13C carboxylic ester and of its respective hyperpolarized metabolite.
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公开(公告)号：US09381257B2
公开(公告)日：2016-07-05
申请号：US14414224
申请日：2013-07-04
Applicant: BRACCO IMAGING S.P.A.
Inventor： Pernille Rose Jensen , Magnus Karlsson , Mathilde H. Lerche , Roberta Napolitano , Fabio Tedoldi , Massimo Visigalli
CPC classification number: A61K49/10 , A61K49/20 , C07F7/0812 , C07F7/0814 , G01R33/282
Abstract: New radical compounds, useful in the field of MRI imaging of formula (I). The radical compounds are in particular new triarylmethyl (“trityl”) radicals which can be used as polarizing agents for polarizing a molecule in the DNP process.
Abstract translation: 新的自由基化合物，可用于式（I）的MRI成像领域。 自由基化合物特别是新的三芳基甲基（“三苯甲基”）基团，其可以用作在DNP方法中使分子偏振的偏振剂。
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