-
公开(公告)号：US11851421B2
公开(公告)日：2023-12-26
申请号：US18010905
申请日：2021-06-22
发明人： Francesco Blasi , Federica Buonsanti , Federico Crivellin , Andrea Ferraris , Laura Orio , Lorena Pizzuto , Roberta Napolitano , Giovanni Valbusa
IPC分类号： C07D403/10 , C09B23/01 , C07D403/14
CPC分类号： C07D403/10 , C07D403/14 , C09B23/0066 , C09B23/0075
摘要： The present invention relates to the field of optical imaging. More particularly, it relates to compounds of the cyanine family with near-infrared emission characterized by improved physico-chemical and biological properties and to conjugates with biological ligands thereof. The invention also relates to the use of these compounds as optical diagnostic agents in imaging or therapy of solid tumors, to the methods for their preparation and to the compositions comprising them. The compounds have formula (I), formula (I), wherein X is direct bond or —O—; Y is a group selected from linear or branched C1-C6 alkyl, C3-C7 cycloalkyl and heterocyclyl, substituted by at least two hydroxyl groups; R1 and R2 are each independently a linear or branched C1-C6 alkyl substituted by a group selected from —SO3H, —COOH, —CONH2 and —COO—C1-C6 alkyl; and R3 is hydrogen, —SO3H or a linear or branched C1-C6 alkyl substituted by —COOH or —CONH—Y, wherein Y is a group selected from linear or branched C1-C6 alkyl, C3-C7 cycloalkyl and heterocyclyl, substituted by at least two hydroxyl groups.
-
公开(公告)号：US09567350B2
公开(公告)日：2017-02-14
申请号：US14623202
申请日：2015-02-16
IPC分类号： C07F5/00 , C07C227/16 , C07C227/40
CPC分类号： C07F5/003 , C07C227/16 , C07C227/40 , C07C229/76
摘要： The present invention generally relies on a process for the preparation of chelated compounds, comprising the selective interaction between a solid matrix and a chelating agent. In more details, the present invention enables the preparation of chelated compounds useful as diagnostic agents, in high yields and in a reliable way.
摘要翻译： 本发明通常依赖于制备螯合化合物的方法，其包括固体基质和螯合剂之间的选择性相互作用。 更详细地说，本发明能够以高产率和可靠的方式制备用作诊断剂的螯合化合物。
-
搜索结果
2 条记录 (耗时 0.012 秒)
