公开(公告)号：US20210196840A1

公开(公告)日：2021-07-01

申请号：US17199122

申请日：2021-03-11

Applicant: BRACCO IMAGING S.P.A.

Inventor： Roberta NAPOLITANO ,  Luciano LATTUADA ,  Zsolt BARANYAI ,  Nicole GUIDOLIN ,  Giuseppe MARAZZI

IPC: A61K49/10 ,  C07F5/00

Abstract: The present invention relates to the RRR/SSS pair of enantiomers of the of Gd(PCTA-tris-glutamic glutaric acid), the single enantiomers of the pair, the pharmaceutically acceptable salts thereof, their amide derivatives, and compositions comprising at least 50% of these compounds.

公开(公告)号：US20180036436A1

公开(公告)日：2018-02-08

申请号：US15551612

申请日：2016-02-25

Applicant: BRACCO IMAGING S.P.A.

Inventor： Zsolt BARANYAI ,  Zoltán GARDA ,  Simona GHIANI ,  Ferenc Krisztián KÁLMÁN ,  László KRUSPER ,  Alessandro MAIOCCHI ,  Gyula TIRCSÓ ,  Imre TOTH

IPC: A61K49/10 ,  C07D295/185 ,  C07D211/42 ,  C07D211/46 ,  C07D211/48 ,  C07D207/34 ,  C07D211/62 ,  C07D211/16 ,  C07D295/192 ,  C07D491/107 ,  C07D221/22 ,  C07D471/08 ,  G01N33/58 ,  G01N24/08 ,  A61B5/055 ,  C07D207/325

CPC classification number: A61K49/106 ,  A61B5/055 ,  A61B2503/40 ,  A61K49/103 ,  C07C237/06 ,  C07D207/325 ,  C07D207/34 ,  C07D211/16 ,  C07D211/42 ,  C07D211/46 ,  C07D211/48 ,  C07D211/62 ,  C07D221/22 ,  C07D295/185 ,  C07D295/192 ,  C07D401/12 ,  C07D403/12 ,  C07D471/08 ,  C07D491/107 ,  G01N24/08 ,  G01N33/58

Abstract: The present invention relates to novel substituted ethylenediaminetetraacetic acid bisamide derivatives, their complexes with Mn(II) ion and the use thereof as contrast agents for Magnetic Resonance Imaging (MRI) analysis.

公开(公告)号：US20240366802A1

公开(公告)日：2024-11-07

申请号：US18734341

申请日：2024-06-05

Applicant: BRACCO IMAGING S.P.A.

Inventor： Roberta NAPOLITANO ,  Luciano LATTUADA ,  Zsolt BARANYAI ,  Nicole GUIDOLIN ,  Giuseppe MARAZZI

IPC: A61K49/10 ,  C07D471/08 ,  C07F5/00

Abstract: The present invention relates to the RRR/SSS pair of enantiomers of the of Gd(PCTA-tris-glutamic acid), the single enantiomers of the pair, the pharmaceutically acceptable salts thereof, their amide derivatives, and compositions comprising at least 50% of these compounds.

公开(公告)号：US20200376145A1

公开(公告)日：2020-12-03

申请号：US16766619

申请日：2019-08-06

Applicant: BRACCO IMAGING S.P.A.

Inventor： Roberta NAPOLITANO ,  Luciano LATTUADA ,  Zsolt BARANYAI ,  Nicole GUIDOLIN ,  Giuseppe MARAZZI

IPC: A61K49/10 ,  C07F5/00

Abstract: The present invention relates to the RRR/SSS pair of enantiomers of the of Gd(PCTA-tris-glutamic acid), the single enantiomers of the pair, the pharmaceutically acceptable salts thereof, their amide derivatives, and compositions comprising at least 50% of these compounds.

公开(公告)号：US20220370646A1

公开(公告)日：2022-11-24

申请号：US17771168

申请日：2020-10-20

Applicant: BRACCO IMAGING S.P.A.

Inventor： Zsolt BARANYAI ,  Mariangela BOCCALON ,  Federica BUONSANTI ,  Federico CRIVELLIN ,  Alessandro MAIOCCHI ,  Roberta MAZZON ,  Fabio TEDOLDI ,  Fulvio UGGERI

IPC: A61K49/10

Abstract: The present invention relates to pharmaceutical compositions comprising an gadolinium-complex and a saturated macrocyclic tetraamine that find application in diagnostic imaging as diagnostic agents, in particular as contrast agents having improved tolerability, specifically in Magnetic Resonance Imaging (MRI), and to their preparation.

公开(公告)号：US20220016275A1

公开(公告)日：2022-01-20

申请号：US17292479

申请日：2019-11-12

Applicant: BRACCO IMAGING S.P.A.

Inventor： Zsolt BARANYAI ,  Simona GHIANI ,  Alessandro MAIOCCHI ,  Ivan HAWALA

IPC: A61K51/08 ,  C07K7/64 ,  A61P35/00

Abstract: A chelating compound of formula (I) or a pharmaceutically acceptable salt thereof and its complexes with metals or radioisotopes thereof. The invention further relates to the preparation of such ligand and complexes as well as to their use as diagnostic or therapeutic agents.