公开(公告)号：US20210284611A1

公开(公告)日：2021-09-16

申请号：US17263642

申请日：2019-07-25

申请人： F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A.

发明人： Nicolas TESSON ,  Jordi DE MIER VINUE ,  Paolo STABILE ,  Pierluigi PADOVAN ,  Matteo DE POLI ,  Angelo RESTELLI

IPC分类号： C07D231/46

摘要： Object of the present invention is a highly stable crystalline form of Eltrombopag (ETP) monoethanolamine salt, named Form D1, having the highest thermodynamically stability with excellent non-hygroscopicity, and particularly well suitable for pharmaceutical purposes, with related process.

公开(公告)号：US20210198211A1

公开(公告)日：2021-07-01

申请号：US17263636

申请日：2019-07-25

申请人： F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A.

发明人： Nicolas TESSON ,  Jordi DE MIER VINUE ,  Paolo STABILE ,  Pierluigi PADOVAN ,  Matteo DE POLI ,  Angelo RESTELLI

IPC分类号： C07D231/46

摘要： Object of the present invention is a better crystalline form of Eltrombopag (ETP) monoethanolamine salt, named Form D, stable, suitable for pharmaceutical purposes, and with the highest solubility in water and excellent non-hygroscopicity, then the related process and intermediates thereof.

公开(公告)号：US20210163401A1

公开(公告)日：2021-06-03

申请号：US17059594

申请日：2019-06-07

申请人： F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A.

发明人： Stefano FOGAL ,  Paolo STABILE ,  Pierluigi PADOVAN ,  Matteo DE POLI ,  Angelo RESTELLI

IPC分类号： C07C227/20 ,  C12N9/04

摘要： The present invention relates to a process for the preparation of Droxidopa by means of an improved enzymatic reduction of a compound of formula (II): (II), wherein R1, R2 is independent hydrogen, acetyl, R3 is hydrogen, a C1-C4 linear or branched alkyl group and R4 is hydrogen or an amine protecting group.