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1.发明申请公开(公告)号：US20180088112A1
公开(公告)日：2018-03-29
申请号：US15715028
申请日：2017-09-25
发明人： Christina Fan , Christina Chang , Eleen Shum , Olaf Zoellner , Nidhanjali Bansal , James Ghadiali , Gretchen Yinbon Lam , Eric Jensen , Jurg Rohrer , Brent Gaylord , Jody Martin , Jason G. Vidal
IPC分类号： G01N33/566 , C12Q1/68 , G01N33/543 , C12N15/10
CPC分类号： G01N33/566 , B01J2219/00646 , B01J2219/00722 , B01J2219/00725 , C07K2319/01 , C12N15/1006 , C12N15/1096 , C12Q1/68 , C12Q1/6804 , C12Q1/6806 , C12Q1/6823 , C12Q1/6869 , G01N33/505 , G01N33/54306 , G01N33/54313 , G01N33/6842 , G01N33/6857 , G06F19/00 , G16B25/10 , G16B99/00 , G16H10/20 , G16H20/13 , C12Q2525/161 , C12Q2525/173 , C12Q2563/179 , C12Q2565/514
摘要： Some embodiments disclosed herein provide a plurality of compositions each comprising a protein binding reagent conjugated with an oligonucleotide. The oligonucleotide comprises a unique identifier for the protein binding reagent it is conjugated with, and the protein binding reagent is capable of specifically binding to a protein target. Further disclosed are methods and kits for quantitative analysis of a plurality of protein targets in a sample and for simultaneous quantitative analysis of protein and nucleic acid targets in a sample. Also disclosed herein are systems and methods for preparing a labeled biomolecule reagent, including a labeled biomolecule agent comprising a protein binding reagent conjugated with an oligonucleotide.
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公开(公告)号：US07442665B2
公开(公告)日：2008-10-28
申请号：US10772894
申请日：2004-02-04
申请人： Peter G. Schultz , Xiaodong Xiang , Isy Goldwasser , Gabriel Brice{hacek over (n)}o , Xiao-Dong Sun , Kai-An Wang
发明人： Peter G. Schultz , Xiaodong Xiang , Isy Goldwasser , Gabriel Brice{hacek over (n)}o , Xiao-Dong Sun , Kai-An Wang
CPC分类号： C04B35/16 , B01J19/0046 , B01J2219/00313 , B01J2219/00317 , B01J2219/00378 , B01J2219/0043 , B01J2219/00432 , B01J2219/00436 , B01J2219/00441 , B01J2219/00443 , B01J2219/00475 , B01J2219/005 , B01J2219/00511 , B01J2219/00515 , B01J2219/0052 , B01J2219/00527 , B01J2219/00531 , B01J2219/00533 , B01J2219/00536 , B01J2219/0054 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00628 , B01J2219/0063 , B01J2219/00635 , B01J2219/00637 , B01J2219/00644 , B01J2219/00646 , B01J2219/00648 , B01J2219/00659 , B01J2219/00689 , B01J2219/00691 , B01J2219/00711 , B01J2219/0072 , B01J2219/00722 , B01J2219/00736 , B01J2219/00745 , B01J2219/00747 , B01J2219/00752 , B01J2219/00754 , B82Y25/00 , B82Y30/00 , C01G51/006 , C01G51/68 , C01P2002/34 , C01P2002/52 , C01P2002/72 , C01P2006/40 , C01P2006/42 , C04B35/01 , C04B35/4508 , C04B35/4521 , C04B35/4525 , C04B35/62218 , C04B2235/3206 , C04B2235/3208 , C04B2235/3213 , C04B2235/3215 , C04B2235/3224 , C04B2235/3225 , C04B2235/3227 , C04B2235/3262 , C04B2235/327 , C04B2235/3275 , C04B2235/3284 , C04B2235/3286 , C04B2235/3296 , C04B2235/3298 , C04B2235/3418 , C04B2235/3463 , C04B2235/656 , C04B2235/761 , C04B2235/762 , C04B2235/768 , C04B2235/96 , C23C14/042 , C23C14/087 , C23C16/042 , C40B30/08 , C40B40/14 , C40B40/18 , C40B60/08 , C40B60/14 , C40B70/00 , C40B80/00 , G01R33/16 , H01F1/401 , H01F1/407 , H01F10/007 , H01F10/1933 , H01F41/18 , H01F41/34 , H01L43/10 , Y10T428/24479 , Y10T428/24612 , Y10T428/2462 , Y10T428/31 , Y10T428/31645 , Y10T428/31855 , Y10T428/31931 , Y10T436/25 , Y10T436/2525 , Y10T436/255 , Y10T436/25875
摘要： Methods and apparatus for the preparation and use of a substrate having an array of diverse materials in predefined regions thereon. A substrate having an array of diverse materials thereon is generally prepared by delivering components of materials to predefined regions on a substrate, and simultaneously reacting the components to form at least two materials. Materials which can be prepared using the methods and apparatus of the present invention include, for example, covalent network solids, ionic solids and molecular solids. More particularly, materials which can be prepared using the methods and apparatus of the present invention include, for example, inorganic materials, intermetallic materials, metal alloys, ceramic materials, organic materials, organometallic materials, non-biological organic polymers, composite materials (e.g., inorganic composites, organic composites, or combinations thereof), etc. Once prepared, these materials can be screened for useful properties including, for example, electrical, thermal, mechanical, morphological, optical, magnetic, chemical, or other properties. Thus, the present invention provides methods for the parallel synthesis and analysis of novel materials having useful properties.
摘要翻译： 用于制备和使用在其上的预定区域中具有不同材料阵列的基材的方法和装置。 通常通过将材料的组分递送到衬底上的预定区域，并且同时使组分反应以形成至少两种材料来制备其上具有不同材料阵列的衬底。 可以使用本发明的方法和装置制备的材料包括例如共价网络固体，离子固体和分子固体。 更具体地，可以使用本发明的方法和装置制备的材料包括例如无机材料，金属间材料，金属合金，陶瓷材料，有机材料，有机金属材料，非生物有机聚合物，复合材料（例如 ，无机复合材料，有机复合材料或其组合）等。一旦制备，可以对这些材料进行筛选以获得有用的性质，包括例如电，热，机械，形态，光学，磁性，化学或其它性质。 因此，本发明提供了用于并行合成和分析具有有用特性的新型材料的方法。
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公开(公告)号：US20040014077A1
公开(公告)日：2004-01-22
申请号：US10350703
申请日：2003-01-23
发明人： Peter G. Schultz , Xiao-Dong Xiang , Isy Goldwasser , Gabriel Briceno , Xiao-Dong Sun , Kai-An Wang
IPC分类号： A61L002/00 , B05D003/00 , C12Q001/68 , G01N033/53 , C12M001/34
CPC分类号： C04B35/16 , B01J19/0046 , B01J2219/00313 , B01J2219/00317 , B01J2219/00378 , B01J2219/0043 , B01J2219/00432 , B01J2219/00436 , B01J2219/00441 , B01J2219/00443 , B01J2219/00475 , B01J2219/005 , B01J2219/00511 , B01J2219/00515 , B01J2219/0052 , B01J2219/00527 , B01J2219/00531 , B01J2219/00533 , B01J2219/00536 , B01J2219/0054 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00628 , B01J2219/0063 , B01J2219/00635 , B01J2219/00637 , B01J2219/00644 , B01J2219/00646 , B01J2219/00648 , B01J2219/00659 , B01J2219/00689 , B01J2219/00691 , B01J2219/00711 , B01J2219/0072 , B01J2219/00722 , B01J2219/00736 , B01J2219/00745 , B01J2219/00747 , B01J2219/00752 , B01J2219/00754 , B82Y25/00 , B82Y30/00 , C01G51/006 , C01G51/68 , C01P2002/34 , C01P2002/52 , C01P2002/72 , C01P2006/40 , C01P2006/42 , C04B35/01 , C04B35/4508 , C04B35/4521 , C04B35/4525 , C04B35/62218 , C04B2235/3206 , C04B2235/3208 , C04B2235/3213 , C04B2235/3215 , C04B2235/3224 , C04B2235/3225 , C04B2235/3227 , C04B2235/3262 , C04B2235/327 , C04B2235/3275 , C04B2235/3284 , C04B2235/3286 , C04B2235/3296 , C04B2235/3298 , C04B2235/3418 , C04B2235/3463 , C04B2235/656 , C04B2235/761 , C04B2235/762 , C04B2235/768 , C04B2235/96 , C23C14/042 , C23C14/087 , C23C16/042 , C40B30/08 , C40B40/14 , C40B40/18 , C40B60/08 , C40B60/14 , C40B70/00 , C40B80/00 , G01R33/16 , H01F1/401 , H01F1/407 , H01F10/007 , H01F10/1933 , H01F41/18 , H01F41/34 , H01L43/10 , Y10T428/24479 , Y10T428/24612 , Y10T428/2462 , Y10T428/31 , Y10T428/31645 , Y10T428/31855 , Y10T428/31931 , Y10T436/25 , Y10T436/2525 , Y10T436/255 , Y10T436/25875
摘要： Methods and apparatus for the preparation and use of a substrate having an array of diverse materials in predefined regions thereon. A substrate having an array of diverse materials thereon is generally prepared by delivering components of materials to predefined regions on a substrate, and simultaneously reacting the components to form at least two materials. Materials which can be prepared using the methods and apparatus of the present invention include, for example, covalent network solids, ionic solids and molecular solids. More particularly, materials which can be prepared using the methods and apparatus of the present invention include, for example, inorganic materials, intermetallic materials, metal alloys, ceramic materials, organic materials, organometallic materials, non-biological organic polymers, composite materials (e.g., inorganic composites, organic composites, or combinations thereof), etc. Once prepared, these materials can be screened for useful properties including, for example, electrical, thermal, mechanical, morphological, optical, magnetic, chemical, or other properties. Thus, the present invention provides methods for the parallel synthesis and analysis of novel materials having useful properties.
摘要翻译： 用于制备和使用在其上的预定区域中具有不同材料阵列的基材的方法和装置。 通常通过将材料的组分递送到衬底上的预定区域，并且同时使组分反应以形成至少两种材料来制备其上具有不同材料阵列的衬底。 可以使用本发明的方法和装置制备的材料包括例如共价网络固体，离子固体和分子固体。 更具体地，可以使用本发明的方法和装置制备的材料包括例如无机材料，金属间材料，金属合金，陶瓷材料，有机材料，有机金属材料，非生物有机聚合物，复合材料（例如 ，无机复合材料，有机复合材料或其组合）等。一旦制备，可以对这些材料进行筛选以获得有用的性质，包括例如电，热，机械，形态，光学，磁性，化学或其它性质。 因此，本发明提供了用于并行合成和分析具有有用特性的新型材料的方法。
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公开(公告)号：US20030231986A1
公开(公告)日：2003-12-18
申请号：US10174190
申请日：2002-06-18
发明人： Thomas E. Kocher
IPC分类号： B01L003/00
CPC分类号： B01L3/545 , B01J19/0046 , B01J2219/00351 , B01J2219/00364 , B01J2219/00378 , B01J2219/00432 , B01J2219/005 , B01J2219/00527 , B01J2219/0054 , B01J2219/00542 , B01J2219/00545 , B01J2219/00547 , B01J2219/00563 , B01J2219/00567 , B01J2219/00576 , B01J2219/00646 , B01J2219/00722 , B01J2219/00725 , B01L2300/021 , B01L2300/022 , B01L2300/0819 , C40B40/06 , C40B40/10 , C40B60/14 , G01N33/585 , G01N2035/00782
摘要： Micro-array receiver apparatus comprising: a micro-array receiver including a substrate and at least a first set of sites of a first biological probe which is adapted to interact with a first biological target sample, the first set of sites formed on the substrate; and an identifier associated with the micro-array receiver for identifying the at least first biological probe.
摘要翻译： 微阵列接收机设备包括：微阵列接收器，其包括衬底和适于与第一生物靶样品相互作用的第一生物探针的至少第一组位点，所述第一组位点形成在所述衬底上; 以及与所述微阵列接收器相关联的用于识别所述至少第一生物探针的标识符。
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公开(公告)号：US06420179B1
公开(公告)日：2002-07-16
申请号：US09127660
申请日：1998-07-31
申请人： Peter G. Schultz , Xiaodong Xiang , Isy Goldwasser
发明人： Peter G. Schultz , Xiaodong Xiang , Isy Goldwasser
IPC分类号： G01N3110
CPC分类号： C04B35/16 , B01J19/0046 , B01J2219/00313 , B01J2219/00317 , B01J2219/00378 , B01J2219/0043 , B01J2219/00432 , B01J2219/00436 , B01J2219/00441 , B01J2219/00443 , B01J2219/00475 , B01J2219/005 , B01J2219/00511 , B01J2219/00515 , B01J2219/0052 , B01J2219/00527 , B01J2219/00531 , B01J2219/00533 , B01J2219/00536 , B01J2219/0054 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00628 , B01J2219/0063 , B01J2219/00635 , B01J2219/00637 , B01J2219/00644 , B01J2219/00646 , B01J2219/00648 , B01J2219/00659 , B01J2219/00689 , B01J2219/00691 , B01J2219/00711 , B01J2219/0072 , B01J2219/00722 , B01J2219/00736 , B01J2219/00745 , B01J2219/00747 , B01J2219/00752 , B01J2219/00754 , B82Y25/00 , B82Y30/00 , C01G51/006 , C01G51/68 , C01P2002/34 , C01P2002/52 , C01P2002/72 , C01P2006/40 , C01P2006/42 , C04B35/01 , C04B35/4508 , C04B35/4521 , C04B35/4525 , C04B35/62218 , C04B2235/3206 , C04B2235/3208 , C04B2235/3213 , C04B2235/3215 , C04B2235/3224 , C04B2235/3225 , C04B2235/3227 , C04B2235/3262 , C04B2235/327 , C04B2235/3275 , C04B2235/3284 , C04B2235/3286 , C04B2235/3296 , C04B2235/3298 , C04B2235/3418 , C04B2235/3463 , C04B2235/656 , C04B2235/761 , C04B2235/762 , C04B2235/768 , C04B2235/96 , C23C14/042 , C23C14/087 , C23C16/042 , C40B30/08 , C40B40/14 , C40B40/18 , C40B60/08 , C40B60/14 , C40B70/00 , C40B80/00 , G01R33/16 , H01F1/401 , H01F1/407 , H01F10/007 , H01F10/1933 , H01F41/18 , H01F41/34 , H01L43/10 , Y10T428/24479 , Y10T428/24612 , Y10T428/2462 , Y10T428/31 , Y10T428/31645 , Y10T428/31855 , Y10T428/31931 , Y10T436/25 , Y10T436/2525 , Y10T436/255 , Y10T436/25875
摘要： Methods and apparatus for the preparation and use of a substrate having an array of diverse materials in predefined regions thereon. A substrate having an array of diverse materials thereon is generally prepared by delivering components of materials to predefined regions on a substrate, and simultaneously reacting the components to form at least two materials. Materials which can be prepared using the methods and apparatus of the present invention include, for example, covalent network solids, ionic solids and molecular solids. More particularly, materials which can be prepared using the methods and apparatus of the present invention include, for example, inorganic materials, intermetallic materials, metal alloys, ceramic materials, organic materials, organometallic materials, non-biological organic polymers, composite materials (e.g., inorganic composites, organic composites, or combinations thereof), etc. Once prepared, these materials can be screened for useful properties including, for example, electrical, thermal, mechanical, morphological, optical, magnetic, chemical, or other properties. Thus, the present invention provides methods for the parallel synthesis and analysis of novel materials having useful properties.
摘要翻译： 用于制备和使用在其上的预定区域中具有不同材料阵列的基材的方法和装置。 通常通过将材料的组分递送到衬底上的预定区域，并且同时使组分反应以形成至少两种材料来制备其上具有不同材料阵列的衬底。 可以使用本发明的方法和装置制备的材料包括例如共价网络固体，离子固体和分子固体。 更具体地，可以使用本发明的方法和装置制备的材料包括例如无机材料，金属间材料，金属合金，陶瓷材料，有机材料，有机金属材料，非生物有机聚合物，复合材料（例如 ，无机复合材料，有机复合材料或其组合）等。一旦制备，可以对这些材料进行筛选以获得有用的性质，包括例如电，热，机械，形态，光学，磁性，化学或其它性质。 因此，本发明提供了用于并行合成和分析具有有用特性的新型材料的方法。
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公开(公告)号：US20010055669A1
公开(公告)日：2001-12-27
申请号：US09794228
申请日：2001-02-26
发明人： Peter G. Schultz , Xiaodong Xiang , Isy Goldwasser
IPC分类号： B32B001/06 , B32B027/00 , B32B017/10 , G01N037/00 , B01L003/00 , B32B003/30
CPC分类号： C04B35/16 , B01J19/0046 , B01J2219/00313 , B01J2219/00317 , B01J2219/00378 , B01J2219/0043 , B01J2219/00432 , B01J2219/00436 , B01J2219/00441 , B01J2219/00443 , B01J2219/00475 , B01J2219/005 , B01J2219/00511 , B01J2219/00515 , B01J2219/0052 , B01J2219/00527 , B01J2219/00531 , B01J2219/00533 , B01J2219/00536 , B01J2219/0054 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00628 , B01J2219/0063 , B01J2219/00635 , B01J2219/00637 , B01J2219/00644 , B01J2219/00646 , B01J2219/00648 , B01J2219/00659 , B01J2219/00689 , B01J2219/00691 , B01J2219/00711 , B01J2219/0072 , B01J2219/00722 , B01J2219/00736 , B01J2219/00745 , B01J2219/00747 , B01J2219/00752 , B01J2219/00754 , B82Y25/00 , B82Y30/00 , C01G51/006 , C01G51/68 , C01P2002/34 , C01P2002/52 , C01P2002/72 , C01P2006/40 , C01P2006/42 , C04B35/01 , C04B35/4508 , C04B35/4521 , C04B35/4525 , C04B35/62218 , C04B2235/3206 , C04B2235/3208 , C04B2235/3213 , C04B2235/3215 , C04B2235/3224 , C04B2235/3225 , C04B2235/3227 , C04B2235/3262 , C04B2235/327 , C04B2235/3275 , C04B2235/3284 , C04B2235/3286 , C04B2235/3296 , C04B2235/3298 , C04B2235/3418 , C04B2235/3463 , C04B2235/656 , C04B2235/761 , C04B2235/762 , C04B2235/768 , C04B2235/96 , C23C14/042 , C23C14/087 , C23C16/042 , C40B30/08 , C40B40/14 , C40B40/18 , C40B60/08 , C40B60/14 , C40B70/00 , C40B80/00 , G01R33/16 , H01F1/401 , H01F1/407 , H01F10/007 , H01F10/1933 , H01F41/18 , H01F41/34 , H01L43/10 , Y10T428/24479 , Y10T428/24612 , Y10T428/2462 , Y10T428/31 , Y10T428/31645 , Y10T428/31855 , Y10T428/31931 , Y10T436/25 , Y10T436/2525 , Y10T436/255 , Y10T436/25875
摘要： Methods and apparatus for the preparation and use of a substrate having an array of diverse materials in predefined regions thereon. A substrate having an array of diverse materials thereon is generally prepared by delivering components of materials to predefined regions on a substrate, and simultaneously reacting the components to form at least two materials. Materials which can be prepared using the methods and apparatus of the present invention include, for example, covalent network solids, ionic solids and molecular solids. More particularly, materials which can be prepared using the methods and apparatus of the present invention include, for example, inorganic materials, intermetallic materials, metal alloys, ceramic materials, organic materials, organometallic materials, non-biological organic polymers, composite materials (e.g., inorganic composites, organic composites, or combinations thereof), etc. Once prepared, these materials can be screened for useful properties including, for example, electrical, thermal, mechanical, morphological, optical, magnetic, chemical, or other properties. Thus, the present invention provides methods for the parallel synthesis and analysis of novel materials having useful properties.
摘要翻译： 用于制备和使用在其上的预定区域中具有不同材料阵列的基材的方法和装置。 通常通过将材料的组分递送到衬底上的预定区域，并且同时使组分反应以形成至少两种材料来制备其上具有不同材料阵列的衬底。 可以使用本发明的方法和装置制备的材料包括例如共价网络固体，离子固体和分子固体。 更具体地，可以使用本发明的方法和装置制备的材料包括例如无机材料，金属间材料，金属合金，陶瓷材料，有机材料，有机金属材料，非生物有机聚合物，复合材料（例如 ，无机复合材料，有机复合材料或其组合）等。一旦制备，可以对这些材料进行筛选以获得有用的性质，包括例如电，热，机械，形态，光学，磁性，化学或其它性质。 因此，本发明提供了用于并行合成和分析具有有用特性的新型材料的方法。
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公开(公告)号：US5776359A
公开(公告)日：1998-07-07
申请号：US438043
申请日：1995-05-08
申请人： Peter G. Schultz , Xiaodong Xiang , Isy Goldwasser
发明人： Peter G. Schultz , Xiaodong Xiang , Isy Goldwasser
IPC分类号： C01G1/00 , B01J19/00 , C01G51/00 , C04B35/01 , C04B35/45 , C04B35/622 , C07B61/00 , C23C14/04 , C23C14/08 , C23C16/04 , C40B30/08 , C40B40/14 , C40B40/18 , C40B60/14 , C40B70/00 , G01N27/00 , G01N35/02 , G01N37/00 , G01R33/16 , H01F1/40 , H01F10/00 , H01F10/18 , H01F10/193 , H01F41/18 , H01F41/34 , H01L43/10 , H01L43/12 , C04B35/50 , C01F11/02 , C01F17/00
CPC分类号： C04B35/16 , B01J19/0046 , B82Y30/00 , C01G51/006 , C01G51/68 , C04B35/01 , C04B35/4508 , C04B35/4521 , C04B35/4525 , C04B35/62218 , C23C14/042 , C23C14/087 , C23C16/042 , C40B40/14 , C40B40/18 , C40B60/08 , C40B80/00 , G01R33/16 , H01F1/407 , H01F10/007 , H01F10/1933 , H01F41/18 , H01F41/34 , H01L43/10 , B01J2219/00313 , B01J2219/00317 , B01J2219/00378 , B01J2219/0043 , B01J2219/00432 , B01J2219/00436 , B01J2219/00441 , B01J2219/00443 , B01J2219/00475 , B01J2219/005 , B01J2219/00511 , B01J2219/00515 , B01J2219/0052 , B01J2219/00527 , B01J2219/00531 , B01J2219/00533 , B01J2219/00536 , B01J2219/0054 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00628 , B01J2219/0063 , B01J2219/00635 , B01J2219/00637 , B01J2219/00644 , B01J2219/00646 , B01J2219/00648 , B01J2219/00659 , B01J2219/00689 , B01J2219/00691 , B01J2219/00711 , B01J2219/0072 , B01J2219/00722 , B01J2219/00736 , B01J2219/00745 , B01J2219/00747 , B01J2219/00752 , B01J2219/00754 , B82Y25/00 , C01P2002/34 , C01P2002/52 , C01P2002/72 , C01P2006/40 , C01P2006/42 , C04B2235/3206 , C04B2235/3208 , C04B2235/3213 , C04B2235/3215 , C04B2235/3224 , C04B2235/3225 , C04B2235/3227 , C04B2235/3262 , C04B2235/327 , C04B2235/3275 , C04B2235/3284 , C04B2235/3286 , C04B2235/3296 , C04B2235/3298 , C04B2235/3418 , C04B2235/3463 , C04B2235/656 , C04B2235/761 , C04B2235/762 , C04B2235/768 , C04B2235/96 , C40B30/08 , C40B60/14 , C40B70/00 , H01F1/401 , Y10T428/24479 , Y10T428/24612 , Y10T428/2462 , Y10T428/31 , Y10T428/31645 , Y10T428/31855 , Y10T428/31931 , Y10T436/25 , Y10T436/2525 , Y10T436/255 , Y10T436/25875
摘要： Methods and apparatus for the preparation and use of a substrate having an array of diverse materials in predefined regions thereon. A substrate having an array of diverse materials thereon is generally prepared by delivering components of materials to predefined regions on a substrate, and simultaneously reacting the components to form at least two materials. Materials which can be prepared using the methods and apparatus of the present invention include, for example, covalent network solids, ionic solids and molecular solids. More particularly, materials which can be prepared using the methods and apparatus of the present invention include, for example, inorganic materials, intermetallic materials, metal alloys, ceramic materials, organic materials, organometallic materials, non-biological organic polymers, composite materials (e.g., inorganic composites, organic composites, or combinations thereof), etc. Once prepared, these materials can be screened for useful properties including, for example, electrical, thermal, mechanical, morphological, optical, magnetic, chemical, or other properties. Thus, the present invention provides methods for the parallel synthesis and analysis of novel materials having useful properties.
摘要翻译： 用于制备和使用在其上的预定区域中具有不同材料阵列的基材的方法和装置。 通常通过将材料的组分递送到衬底上的预定区域，并且同时使组分反应以形成至少两种材料来制备其上具有不同材料阵列的衬底。 可以使用本发明的方法和装置制备的材料包括例如共价网络固体，离子固体和分子固体。 更具体地，可以使用本发明的方法和装置制备的材料包括例如无机材料，金属间材料，金属合金，陶瓷材料，有机材料，有机金属材料，非生物有机聚合物，复合材料（例如 ，无机复合材料，有机复合材料或其组合）等。一旦制备，可以对这些材料进行筛选以获得有用的性质，包括例如电，热，机械，形态，光学，磁性，化学或其它性质。 因此，本发明提供了用于并行合成和分析具有有用特性的新型材料的方法。
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公开(公告)号：US11782059B2
公开(公告)日：2023-10-10
申请号：US16459444
申请日：2019-07-01
发明人： Christina Fan , Olaf Zoellner
IPC分类号： G01N33/566 , G16B99/00 , G01N33/50 , G01N33/543 , G01N33/68 , C12Q1/6804 , G16Z99/00 , C12N15/10 , C12Q1/6806 , C12Q1/6823 , C12Q1/6869 , C12Q1/68 , G16B25/10 , G16H20/13 , G16H10/20
CPC分类号： G01N33/566 , C12N15/1006 , C12N15/1096 , C12Q1/68 , C12Q1/6804 , C12Q1/6806 , C12Q1/6823 , C12Q1/6869 , G01N33/505 , G01N33/54306 , G01N33/54313 , G01N33/6842 , G01N33/6857 , G16B99/00 , G16Z99/00 , B01J2219/00646 , B01J2219/00722 , B01J2219/00725 , C07K2319/01 , G16B25/10 , G16H10/20 , G16H20/13 , C12Q1/6804 , C12Q2525/161 , C12Q2525/173 , C12Q2563/179 , C12Q2565/514
摘要： Some embodiments disclosed herein provide a plurality of compositions each comprising a protein binding reagent conjugated with an oligonucleotide. The oligonucleotide comprises a unique identifier for the protein binding reagent it is conjugated with, and the protein binding reagent is capable of specifically binding to a protein target. Further disclosed are methods and kits for quantitative analysis of a plurality of protein targets in a sample and for simultaneous quantitative analysis of protein and nucleic acid targets in a sample. Also disclosed herein are systems and methods for preparing a labeled biomolecule reagent, including a labeled biomolecule agent comprising a protein binding reagent conjugated with an oligonucleotide.
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9.发明授权Use of acid scavengers for the synthesis of standard length and long-mer nucleic acid arrays 有权使用酸清除剂合成标准长度和长链核酸阵列公开(公告)号：US08062844B2
公开(公告)日：2011-11-22
申请号：US13011030
申请日：2011-01-21
CPC分类号： B01J19/0046 , B01J2219/00317 , B01J2219/00432 , B01J2219/00439 , B01J2219/00441 , B01J2219/00448 , B01J2219/00497 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00637 , B01J2219/00646 , B01J2219/00659 , B01J2219/00675 , B01J2219/00689 , B01J2219/00693 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , B82Y30/00 , C07H21/00 , C07K1/047 , C40B50/14 , Y02P20/55
摘要： Protective groups which may be cleaved with an activatable deprotecting reagents are employed to achieve a highly sensitive, high resolution, combinatorial synthesis of pattern arrays of diverse polymers. In preferred embodiments of the instant invention, the activatable deprotecting reagent is a photoacid generator and the protective groups are DMT for nucleic acids and tBOC for amino acids. This invention has a wide variety of applications and is particularly useful for the solid phase combinatorial synthesis of polymers.
摘要翻译： 可以用可活化的去保护试剂切割的保护基用于实现多种聚合物的图案阵列的高灵敏度，高分辨率，组合合成。 在本发明的优选实施方案中，可活化的去保护试剂是光酸产生剂，保护基是核酸的DMT和氨基酸的tBOC。 本发明具有广泛的应用，并且对聚合物的固相组合合成特别有用。
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10.发明申请Process for high-yield synthesis of standard length and long-mer nucleic acid arrays 审中-公开用于高产率合成标准长度和长聚核苷酸阵列的方法公开(公告)号：US20050164258A1
公开(公告)日：2005-07-28
申请号：US11021700
申请日：2004-12-22
申请人： Martin Goldberg , Robert Kuimelis , Glenn McGall , Nineveh Parker , Guangyu Xu
发明人： Martin Goldberg , Robert Kuimelis , Glenn McGall , Nineveh Parker , Guangyu Xu
IPC分类号： B01J19/00 , C07H21/00 , C07H21/04 , C12M1/34 , C12Q1/68 , C40B40/06 , C40B40/10 , C40B40/12 , C40B50/14 , C40B60/14
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00317 , B01J2219/00432 , B01J2219/00439 , B01J2219/00441 , B01J2219/00448 , B01J2219/00497 , B01J2219/00527 , B01J2219/00529 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00646 , B01J2219/00659 , B01J2219/00675 , B01J2219/00689 , B01J2219/00693 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , C07H21/00 , C07H21/04 , C40B40/06 , C40B40/10 , C40B40/12 , C40B50/14 , C40B60/14 , Y02P20/55
摘要： Protective groups which may be cleaved with an activatable deprotecting reagents are employed to achieve a highly sensitive, high resolution, combinatorial synthesis of pattern arrays of diverse polymers. In preferred embodiments of the instant invention, the activatable deprotecting reagent is a photoacid generator and the protective groups are DMT for nucleic acids and tBOC for amino acids. This invention has a wide variety of applications and is particularly useful for the solid phase combinatorial synthesis of polymers.
摘要翻译： 可以用可活化的去保护试剂切割的保护基用于实现多种聚合物的图案阵列的高灵敏度，高分辨率，组合合成。 在本发明的优选实施方案中，可活化的去保护试剂是光酸产生剂，保护基是核酸的DMT和氨基酸的tBOC。 本发明具有广泛的应用，并且对聚合物的固相组合合成特别有用。
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