发明授权
- 专利标题: Use of acid scavengers for the synthesis of standard length and long-mer nucleic acid arrays
- 专利标题(中): 使用酸清除剂合成标准长度和长链核酸阵列
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申请号: US13011030申请日: 2011-01-21
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公开(公告)号: US08062844B2公开(公告)日: 2011-11-22
- 发明人: Robert G. Kuimelis , Glenn H. McGall , Martin J. Goldberg , Guangyu Xu
- 申请人: Robert G. Kuimelis , Glenn H. McGall , Martin J. Goldberg , Guangyu Xu
- 申请人地址: US CA Santa Clara
- 专利权人: Affymetrix, Inc.
- 当前专利权人: Affymetrix, Inc.
- 当前专利权人地址: US CA Santa Clara
- 主分类号: C08G64/00
- IPC分类号: C08G64/00 ; C08G63/02
摘要:
Protective groups which may be cleaved with an activatable deprotecting reagents are employed to achieve a highly sensitive, high resolution, combinatorial synthesis of pattern arrays of diverse polymers. In preferred embodiments of the instant invention, the activatable deprotecting reagent is a photoacid generator and the protective groups are DMT for nucleic acids and tBOC for amino acids. This invention has a wide variety of applications and is particularly useful for the solid phase combinatorial synthesis of polymers.
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